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Statements

Subject Item
n2:RIV%2F00064203%3A_____%2F12%3A8892%21RIV13-MZ0-00064203
rdf:type
n12:Vysledek skos:Concept
rdfs:seeAlso
http://www.ncbi.nlm.nih.gov/pubmed/23391971
dcterms:description
OBJECTIVES: To evaluate the significance of diabetes mellitus and metformin in patients admitted to medical ICU with lactic acidosis. METHODS: All the patients admitted to medical ICU with serum lactic acid exceeding 5 mmol/L and pH<7.35 were enrolled into analysis. The impact of diabetes mellitus and metformin treatment on ICU presence of lactic acidosis and its mortality was evaluated. The metabolic parameters were compared with respect to the presence of diabetes mellitus and metformin application. RESULTS: Lactic acidosis was detected in 69 (4%) out of 1,755 admitted patients, 44 were nondiabetic and 25 had diabetes mellitus, 11 of them treated with metformin. No significant impact of diabetes mellitus or metformin application on presence of lactic acidosis and its mortality was detected. In nondiabetic subjects mortality was associated with eGFR and the presence of acute renal failure while in diabetic patients with sepsis. Acute renal failure was detected in 9 out of 11 patients on metformin. Three patients died due to sepsis, however only 1 out of 6 due to another cause if renal replacement therapy was started soon after admission. The acidosis was more expressed in diabetic subjects mainly in patients taking metformin. It might be attributed to the more pronounced acute renal failure in diabetic patients. CONCLUSION: The presence of diabetes mellitus and metformin application is not associated with the presence of lactic acidosis in medical ICU and its mortality. The prognosis of acute renal failure of patients on metformin is good if the subjects with sepsis are excluded. OBJECTIVES: To evaluate the significance of diabetes mellitus and metformin in patients admitted to medical ICU with lactic acidosis. METHODS: All the patients admitted to medical ICU with serum lactic acid exceeding 5 mmol/L and pH<7.35 were enrolled into analysis. The impact of diabetes mellitus and metformin treatment on ICU presence of lactic acidosis and its mortality was evaluated. The metabolic parameters were compared with respect to the presence of diabetes mellitus and metformin application. RESULTS: Lactic acidosis was detected in 69 (4%) out of 1,755 admitted patients, 44 were nondiabetic and 25 had diabetes mellitus, 11 of them treated with metformin. No significant impact of diabetes mellitus or metformin application on presence of lactic acidosis and its mortality was detected. In nondiabetic subjects mortality was associated with eGFR and the presence of acute renal failure while in diabetic patients with sepsis. Acute renal failure was detected in 9 out of 11 patients on metformin. Three patients died due to sepsis, however only 1 out of 6 due to another cause if renal replacement therapy was started soon after admission. The acidosis was more expressed in diabetic subjects mainly in patients taking metformin. It might be attributed to the more pronounced acute renal failure in diabetic patients. CONCLUSION: The presence of diabetes mellitus and metformin application is not associated with the presence of lactic acidosis in medical ICU and its mortality. The prognosis of acute renal failure of patients on metformin is good if the subjects with sepsis are excluded.
dcterms:title
Lactic acidosis in medical ICU - the role of diabetes mellitus and metformin Lactic acidosis in medical ICU - the role of diabetes mellitus and metformin
skos:prefLabel
Lactic acidosis in medical ICU - the role of diabetes mellitus and metformin Lactic acidosis in medical ICU - the role of diabetes mellitus and metformin
skos:notation
RIV/00064203:_____/12:8892!RIV13-MZ0-00064203
n12:predkladatel
n14:ico%3A00064203
n3:aktivita
n7:Z n7:I
n3:aktivity
I, Z(MZ0FNM2005)
n3:cisloPeriodika
8
n3:dodaniDat
n9:2013
n3:domaciTvurceVysledku
n4:7627742 n4:2110504 n4:5592542 n4:7972911
n3:druhVysledku
n18:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
146342
n3:idVysledku
RIV/00064203:_____/12:8892
n3:jazykVysledku
n15:eng
n3:klicovaSlova
Lactic acidosis; diabetes mellitus; metformin
n3:klicoveSlovo
n5:Lactic%20acidosis n5:diabetes%20mellitus n5:metformin
n3:kodStatuVydavatele
SE - Švédské království
n3:kontrolniKodProRIV
[82C6F4DE3B90]
n3:nazevZdroje
Neuroendocrinology Letters
n3:obor
n16:FB
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n9:2012
n3:svazekPeriodika
33
n3:tvurceVysledku
Charvát, Jiří Havlín, Jan Hloch, Ondřej Masopust, Jan
n3:zamer
n17:MZ0FNM2005
s:issn
0172-780X
s:numberOfPages
4