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Statements

Subject Item
n2:RIV%2F00064203%3A_____%2F12%3A8625%21RIV13-MZ0-00064203
rdf:type
skos:Concept n5:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1186/ar3836
dcterms:description
Introduction: The purpose of this study was to evaluate and compare the serum levels and local expression of resistin in patients with idiopathic inflammatory myopathies to controls, and to determine the relationship between resistin levels, inflammation and disease activity.Methods: Serum resistin levels were determined in 42 patients with inflammatory myopathies and 27 healthy controls. The association among resistin levels, inflammation, global disease activity and muscle strength was examined. The expression of resistin in muscle tissues from patients with inflammatory myopathies and healthy controls was evaluated. Gene expression and protein release from resistin-stimulated muscle and mononuclear cells were assessed.Conclusions: The results of this study indicate that higher levels of serum resistin are associated with inflammation, higher global disease activity index and muscle injury in patients with myositis-specific anti-Jo-1 antibody and patients with dermatomyositis. Furthermore, up-regulation of resistin in muscle tissue and resistin-induced synthesis of pro-inflammatory cytokines in mononuclear cells suggest a potential role for resistin in the pathogenesis of inflammatory myopathies. Introduction: The purpose of this study was to evaluate and compare the serum levels and local expression of resistin in patients with idiopathic inflammatory myopathies to controls, and to determine the relationship between resistin levels, inflammation and disease activity.Methods: Serum resistin levels were determined in 42 patients with inflammatory myopathies and 27 healthy controls. The association among resistin levels, inflammation, global disease activity and muscle strength was examined. The expression of resistin in muscle tissues from patients with inflammatory myopathies and healthy controls was evaluated. Gene expression and protein release from resistin-stimulated muscle and mononuclear cells were assessed.Conclusions: The results of this study indicate that higher levels of serum resistin are associated with inflammation, higher global disease activity index and muscle injury in patients with myositis-specific anti-Jo-1 antibody and patients with dermatomyositis. Furthermore, up-regulation of resistin in muscle tissue and resistin-induced synthesis of pro-inflammatory cytokines in mononuclear cells suggest a potential role for resistin in the pathogenesis of inflammatory myopathies.
dcterms:title
Resistin in idiopathic inflammatory myopathies Resistin in idiopathic inflammatory myopathies
skos:prefLabel
Resistin in idiopathic inflammatory myopathies Resistin in idiopathic inflammatory myopathies
skos:notation
RIV/00064203:_____/12:8625!RIV13-MZ0-00064203
n5:predkladatel
n13:ico%3A00064203
n4:aktivita
n9:S n9:P n9:I
n4:aktivity
I, P(NS10614), S
n4:cisloPeriodika
3
n4:dodaniDat
n8:2013
n4:domaciTvurceVysledku
n6:7014457 n6:3100979
n4:druhVysledku
n10:J
n4:duvernostUdaju
n19:S
n4:entitaPredkladatele
n18:predkladatel
n4:idSjednocenehoVysledku
165227
n4:idVysledku
RIV/00064203:_____/12:8625
n4:jazykVysledku
n15:eng
n4:klicovaSlova
autoantibody; C reactive protein; cytokine; interleukin 1beta; interleukin 6; monocyte chemotactic protein 1; myoglobin; resistin
n4:klicoveSlovo
n7:myoglobin n7:interleukin%206 n7:C%20reactive%20protein n7:monocyte%20chemotactic%20protein%201 n7:cytokine n7:autoantibody n7:resistin n7:interleukin%201beta
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[089197ED2CF9]
n4:nazevZdroje
Arthritis Research & Therapy
n4:obor
n11:EC
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
11
n4:projekt
n17:NS10614
n4:rokUplatneniVysledku
n8:2012
n4:svazekPeriodika
14
n4:tvurceVysledku
Filkova, M. Zámečník, Josef Mann, H. Klein, M. Senolt, L. Kuncová, Klára Gay, S. Vencovský, J. Hulejova, H. Cerezo, LA Plestilova, L.
n4:wos
000314972600013
s:issn
1478-6354
s:numberOfPages
9