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Statements

Subject Item
n2:RIV%2F00064203%3A_____%2F12%3A8251%21RIV13-MZ0-00064203
rdf:type
skos:Concept n15:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1007/s00431-012-1833-2
dcterms:description
We read the study of Kurt et al. [4] and we believe that sodium chloride difference (Diff(NaCl)) and Cl Na ratio cannot be considered as an alternative method for assessment of unmeasured anions or tissue acids (TA). Significant correlation between Cl Na ratio and TA is not an unexpected result because metabolic acidosis (MAC) is generally caused either by loss of bicarbonate (insufficient renal synthesis of HCO3 compensated by an increase of Cl) or by retention of acids (chlorides remain unchanged), frequently by both. The correlation is a weak evidence that one method can replace another. The confidence interval is not specified but at first glance it is apparent that variability is too high (Fig. 1e). Cl Na ratio cannot be reliably used as a bedside method as it cannot exclude the accumulation of TA in individual case. Cl Na ratio indicates only approximately whether MAC with unchanged Cl is associated with retention of acids and MAC with hyperchloremia with insufficient synthesis of bicarbonate. We read the study of Kurt et al. [4] and we believe that sodium chloride difference (Diff(NaCl)) and Cl Na ratio cannot be considered as an alternative method for assessment of unmeasured anions or tissue acids (TA). Significant correlation between Cl Na ratio and TA is not an unexpected result because metabolic acidosis (MAC) is generally caused either by loss of bicarbonate (insufficient renal synthesis of HCO3 compensated by an increase of Cl) or by retention of acids (chlorides remain unchanged), frequently by both. The correlation is a weak evidence that one method can replace another. The confidence interval is not specified but at first glance it is apparent that variability is too high (Fig. 1e). Cl Na ratio cannot be reliably used as a bedside method as it cannot exclude the accumulation of TA in individual case. Cl Na ratio indicates only approximately whether MAC with unchanged Cl is associated with retention of acids and MAC with hyperchloremia with insufficient synthesis of bicarbonate.
dcterms:title
The use of sodium-chloride difference and chloride-sodium ratio in the evaluation of metabolic acidosis in critically ill patients The use of sodium-chloride difference and chloride-sodium ratio in the evaluation of metabolic acidosis in critically ill patients
skos:prefLabel
The use of sodium-chloride difference and chloride-sodium ratio in the evaluation of metabolic acidosis in critically ill patients The use of sodium-chloride difference and chloride-sodium ratio in the evaluation of metabolic acidosis in critically ill patients
skos:notation
RIV/00064203:_____/12:8251!RIV13-MZ0-00064203
n15:predkladatel
n17:ico%3A00064203
n3:aktivita
n14:I
n3:aktivity
I
n3:cisloPeriodika
11
n3:dodaniDat
n4:2013
n3:domaciTvurceVysledku
n5:3057232 n5:5592542 n5:3610543 n5:7627742 n5:8719446
n3:druhVysledku
n10:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
176419
n3:idVysledku
RIV/00064203:_____/12:8251
n3:jazykVysledku
n18:eng
n3:klicovaSlova
anion gap
n3:klicoveSlovo
n13:anion%20gap
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[34A504EEDD10]
n3:nazevZdroje
European Journal of Pediatrics
n3:obor
n8:FG
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n4:2012
n3:svazekPeriodika
171
n3:tvurceVysledku
Charvát, Jiří Havlín, Jan Horáčková, Miroslava Matoušovic, Karel Schück, Otto
n3:wos
000310810700023
s:issn
0340-6199
s:numberOfPages
1