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Statements

Subject Item
n2:RIV%2F00064203%3A_____%2F12%3A8242%21RIV13-MZ0-00064203
rdf:type
n10:Vysledek skos:Concept
rdfs:seeAlso
http://www.biomed.cas.cz/physiolres/pdf/61%20Suppl%202/61_S43.pdf
dcterms:description
The vessels on the fetal side of the placenta differ from most other vascular beds except the lungs in that they respond to acute hypoxia by vasoconstriction. An essential role of calcium influx in the mechanism of this hypoxic fetoplacental vasoconstriction (HFPV) has been shown previously. That finding does not, however, exclude the possible involvement of other mechanisms of vascular tone regulation. In this study we tested the hypothesis that Rho-kinase-mediated calcium sensitization is involved in HFPV. We used a model of isolated rat placenta dually perfused (from both the maternal and fetal side) with Krebs salt solution saturated with normoxic and hypoxic gas mixture respectively at constant flow rate. Rho-kinase pathway was inhibited by fasudil (10 mu M). We found that fasudil reduced basal normoxic fetoplacental vascular resistance and completely prevented HFPV. This suggests that the activity of Rho-kinase signaling pathway is essential for HFPV. The vessels on the fetal side of the placenta differ from most other vascular beds except the lungs in that they respond to acute hypoxia by vasoconstriction. An essential role of calcium influx in the mechanism of this hypoxic fetoplacental vasoconstriction (HFPV) has been shown previously. That finding does not, however, exclude the possible involvement of other mechanisms of vascular tone regulation. In this study we tested the hypothesis that Rho-kinase-mediated calcium sensitization is involved in HFPV. We used a model of isolated rat placenta dually perfused (from both the maternal and fetal side) with Krebs salt solution saturated with normoxic and hypoxic gas mixture respectively at constant flow rate. Rho-kinase pathway was inhibited by fasudil (10 mu M). We found that fasudil reduced basal normoxic fetoplacental vascular resistance and completely prevented HFPV. This suggests that the activity of Rho-kinase signaling pathway is essential for HFPV.
dcterms:title
Rho-Kinase Inhibition Attenuates Acute Hypoxic Fetoplacental Vasoconstriction in the Rat Rho-Kinase Inhibition Attenuates Acute Hypoxic Fetoplacental Vasoconstriction in the Rat
skos:prefLabel
Rho-Kinase Inhibition Attenuates Acute Hypoxic Fetoplacental Vasoconstriction in the Rat Rho-Kinase Inhibition Attenuates Acute Hypoxic Fetoplacental Vasoconstriction in the Rat
skos:notation
RIV/00064203:_____/12:8242!RIV13-MZ0-00064203
n10:predkladatel
n19:ico%3A00064203
n3:aktivita
n16:I n16:P
n3:aktivity
I, P(GA305/08/0108)
n3:cisloPeriodika
2
n3:dodaniDat
n11:2013
n3:domaciTvurceVysledku
n9:8095701
n3:druhVysledku
n17:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
165554
n3:idVysledku
RIV/00064203:_____/12:8242
n3:jazykVysledku
n6:eng
n3:klicovaSlova
Hypoxic fetoplacental vasoconstriction; Calcium sensitization; Rho-kinase pathway; Placenta; Fasudil; smooth-muscle; pulmonary; placenta; arteries; calcium
n3:klicoveSlovo
n5:Hypoxic%20fetoplacental%20vasoconstriction n5:placenta n5:arteries n5:calcium n5:Placenta n5:Calcium%20sensitization n5:Fasudil n5:Rho-kinase%20pathway n5:smooth-muscle n5:pulmonary
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[6EC3A9FC1365]
n3:nazevZdroje
Physiological Research
n3:obor
n18:ED
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
4
n3:projekt
n4:GA305%2F08%2F0108
n3:rokUplatneniVysledku
n11:2012
n3:svazekPeriodika
61
n3:tvurceVysledku
Herget, Jan Kafka, Petr Hampl, Václav Vajnerová, Olga
n3:wos
000310260000006
s:issn
0862-8408
s:numberOfPages
6