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Statements

Subject Item
n2:RIV%2F00064203%3A_____%2F12%3A8211%21RIV13-MZ0-00064203
rdf:type
n5:Vysledek skos:Concept
rdfs:seeAlso
http://www.ncbi.nlm.nih.gov/pubmed/22847214
dcterms:description
Clinical observations stemming from widespread employment of restorative L-3,4-dihydroxyphenylalanine (L-DOPA) therapy for management of dyskinesia in Parkinson's Disease (PD) patients implicate a regulatory role for endogenous morphine in central nervous system dopamine neurotransmission. Reciprocally, it appears that restorative L-DOPA administration has provided us with a compelling in vivo pharmacological model for targeting peripheral sites involved in endogenous morphine expression in human subjects. The biological activities underlying endogenous morphine expression and its interaction with its major precursor dopamine strongly suggest that endogenous morphine systems are reciprocally dysregulated in PD. These critical issues are examined from historical and current perspectives within our short review. Clinical observations stemming from widespread employment of restorative L-3,4-dihydroxyphenylalanine (L-DOPA) therapy for management of dyskinesia in Parkinson's Disease (PD) patients implicate a regulatory role for endogenous morphine in central nervous system dopamine neurotransmission. Reciprocally, it appears that restorative L-DOPA administration has provided us with a compelling in vivo pharmacological model for targeting peripheral sites involved in endogenous morphine expression in human subjects. The biological activities underlying endogenous morphine expression and its interaction with its major precursor dopamine strongly suggest that endogenous morphine systems are reciprocally dysregulated in PD. These critical issues are examined from historical and current perspectives within our short review.
dcterms:title
Parkinson's disease, L-DOPA, and endogenous morphine: A revisit Parkinson's disease, L-DOPA, and endogenous morphine: A revisit
skos:prefLabel
Parkinson's disease, L-DOPA, and endogenous morphine: A revisit Parkinson's disease, L-DOPA, and endogenous morphine: A revisit
skos:notation
RIV/00064203:_____/12:8211!RIV13-MZ0-00064203
n5:predkladatel
n17:ico%3A00064203
n6:aktivita
n8:I n8:N
n6:aktivity
I, N
n6:cisloPeriodika
8
n6:dodaniDat
n10:2013
n6:domaciTvurceVysledku
n16:3878392
n6:druhVysledku
n9:J
n6:duvernostUdaju
n12:S
n6:entitaPredkladatele
n15:predkladatel
n6:idSjednocenehoVysledku
157852
n6:idVysledku
RIV/00064203:_____/12:8211
n6:jazykVysledku
n18:eng
n6:klicovaSlova
dopamine; L-DOPA; Parkinson's disease; morphine; tetrahydropapaveroline; nitric-oxide release; white blood-cells; cocaine-evoked release; ventral tegmental area; tetrahydroisoquinoline alkaloids; rat-brain; in-vivo; opiate alkaloids; invertebrate ganglia; synthesize morphine
n6:klicoveSlovo
n7:tetrahydroisoquinoline%20alkaloids n7:tetrahydropapaveroline n7:dopamine n7:white%20blood-cells n7:in-vivo n7:L-DOPA n7:invertebrate%20ganglia n7:rat-brain n7:morphine n7:Parkinson%27s%20disease n7:cocaine-evoked%20release n7:opiate%20alkaloids n7:synthesize%20morphine n7:nitric-oxide%20release n7:ventral%20tegmental%20area
n6:kodStatuVydavatele
PL - Polská republika
n6:kontrolniKodProRIV
[0E3A95273F04]
n6:nazevZdroje
Medical Science Monitor
n6:obor
n14:FP
n6:pocetDomacichTvurcuVysledku
1
n6:pocetTvurcuVysledku
7
n6:rokUplatneniVysledku
n10:2012
n6:svazekPeriodika
18
n6:tvurceVysledku
Kralickova, M. Stefano, GB Kuželová, Hana Esch, T. Ptacek, R. Mantione, KJ Kream, R. M.
n6:wos
000308604800025
s:issn
1234-1010
s:numberOfPages
5