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Statements

Subject Item
n2:RIV%2F00064203%3A_____%2F12%3A8209%21RIV13-MZ0-00064203
rdf:type
skos:Concept n6:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1016/S1470-2045(12)70377-7
dcterms:description
Background Trials of imatinib have provided evidence of activity in adults with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (ALL), but the drug's role when given with multidrug chemotherapy to children is unknown. This study assesses the safety and efficacy of oral imatinib in association with a Berlin-Frankfurt-Munster intensive chemotherapy regimen and allo geneic stem-cell transplantation for paediatric patients with Philadelphia-chromosome-positive ALL. Background Trials of imatinib have provided evidence of activity in adults with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (ALL), but the drug's role when given with multidrug chemotherapy to children is unknown. This study assesses the safety and efficacy of oral imatinib in association with a Berlin-Frankfurt-Munster intensive chemotherapy regimen and allo geneic stem-cell transplantation for paediatric patients with Philadelphia-chromosome-positive ALL.
dcterms:title
Imatinib after induction for treatment of children and adolescents with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (EsPhALL): a randomised, open-label, intergroup study Imatinib after induction for treatment of children and adolescents with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (EsPhALL): a randomised, open-label, intergroup study
skos:prefLabel
Imatinib after induction for treatment of children and adolescents with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (EsPhALL): a randomised, open-label, intergroup study Imatinib after induction for treatment of children and adolescents with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (EsPhALL): a randomised, open-label, intergroup study
skos:notation
RIV/00064203:_____/12:8209!RIV13-MZ0-00064203
n6:predkladatel
n7:ico%3A00064203
n3:aktivita
n11:I
n3:aktivity
I
n3:cisloPeriodika
9
n3:dodaniDat
n10:2013
n3:domaciTvurceVysledku
n15:4977939
n3:druhVysledku
n13:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
140525
n3:idVysledku
RIV/00064203:_____/12:8209
n3:jazykVysledku
n9:eng
n3:klicovaSlova
stem-cell transplantation; tyrosine kinase; aieop-bfm; t-cell; chemotherapy; therapy; combination; stratification; inhibition; mesylate
n3:klicoveSlovo
n4:stratification n4:tyrosine%20kinase n4:therapy n4:stem-cell%20transplantation n4:chemotherapy n4:inhibition n4:combination n4:mesylate n4:aieop-bfm n4:t-cell
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[0EF89AEAD1E0]
n3:nazevZdroje
Lancet Oncology
n3:obor
n17:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
16
n3:rokUplatneniVysledku
n10:2012
n3:svazekPeriodika
13
n3:tvurceVysledku
Schrappe, M. Castor, A. Sáha, V. Gandemer, V. Arico, M. Starý, Jan Lucchini, G. Vora, A. Biondi, A. Valsecchi, MG De Lorenzo, P. Li, CK Campbell, M. Escherich, G. Pieters, R. Rottgers, S.
n3:wos
000308425600021
s:issn
1470-2045
s:numberOfPages
10