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Statements

Subject Item
n2:RIV%2F00064203%3A_____%2F12%3A8130%21RIV13-MZ0-00064203
rdf:type
skos:Concept n9:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.2337/dc12-0438
dcterms:description
OBJECTIVE-To investigate if there is a reduced risk of type 1 diabetes in children breastfed or exclusively breastfed by performing a pooled analysis with adjustment for recognized confounders. RESEARCH DESIGN AND METHODS-Relevant studies were identified from literature searches using MEDLINE, Web of Science, and EMBASE. Authors of relevant studies were asked to provide individual participant data or conduct prespecified analyses. Meta-analysis techniques were used to combine odds ratios (ORs) and investigate heterogeneity between studies. RESULTS-Data were available from 43 studies including 9,874 patients with type 1 diabetes. Overall, there was a reduction in the risk of diabetes after exclusive breast-feeding for >2 weeks (20 studies; OR = 0.75, 95% CI 0.64-0.88), the association after exclusive breast-feeding for >3 months was weaker (30 studies; OR = 0.87, 95% CI 0.75-1.00), and no association was observed after (nonexclusive) breast-feeding for >2 weeks (28 studies; OR = 0.93, 95% CI 0.81-1.07) or >3 months (29 studies; OR = 0.88, 95% CI 0.78-1.00). These associations were all subject to marked heterogeneity (I-2 = 58, 76, 54, and 68%, respectively). In studies with lower risk of bias, the reduced risk after exclusive breast-feeding for >2 weeks remained (12 studies; OR = 0.86, 95% CI 0.75-0.99), and heterogeneity was reduced (I-2 = 0%). Adjustments for potential confounders altered these estimates very little. CONCLUSIONS-The pooled analysis suggests weak protective associations between exclusive breast-feeding and type 1 diabetes risk. However, these findings are difficult to interpret because of the marked variation in effect and possible biases (particularly recall bias) inherent in the included studies. OBJECTIVE-To investigate if there is a reduced risk of type 1 diabetes in children breastfed or exclusively breastfed by performing a pooled analysis with adjustment for recognized confounders. RESEARCH DESIGN AND METHODS-Relevant studies were identified from literature searches using MEDLINE, Web of Science, and EMBASE. Authors of relevant studies were asked to provide individual participant data or conduct prespecified analyses. Meta-analysis techniques were used to combine odds ratios (ORs) and investigate heterogeneity between studies. RESULTS-Data were available from 43 studies including 9,874 patients with type 1 diabetes. Overall, there was a reduction in the risk of diabetes after exclusive breast-feeding for >2 weeks (20 studies; OR = 0.75, 95% CI 0.64-0.88), the association after exclusive breast-feeding for >3 months was weaker (30 studies; OR = 0.87, 95% CI 0.75-1.00), and no association was observed after (nonexclusive) breast-feeding for >2 weeks (28 studies; OR = 0.93, 95% CI 0.81-1.07) or >3 months (29 studies; OR = 0.88, 95% CI 0.78-1.00). These associations were all subject to marked heterogeneity (I-2 = 58, 76, 54, and 68%, respectively). In studies with lower risk of bias, the reduced risk after exclusive breast-feeding for >2 weeks remained (12 studies; OR = 0.86, 95% CI 0.75-0.99), and heterogeneity was reduced (I-2 = 0%). Adjustments for potential confounders altered these estimates very little. CONCLUSIONS-The pooled analysis suggests weak protective associations between exclusive breast-feeding and type 1 diabetes risk. However, these findings are difficult to interpret because of the marked variation in effect and possible biases (particularly recall bias) inherent in the included studies.
dcterms:title
Breast-Feeding and Childhood-Onset Type 1 Diabetes A pooled analysis of individual participant data from 43 observational studies Breast-Feeding and Childhood-Onset Type 1 Diabetes A pooled analysis of individual participant data from 43 observational studies
skos:prefLabel
Breast-Feeding and Childhood-Onset Type 1 Diabetes A pooled analysis of individual participant data from 43 observational studies Breast-Feeding and Childhood-Onset Type 1 Diabetes A pooled analysis of individual participant data from 43 observational studies
skos:notation
RIV/00064203:_____/12:8130!RIV13-MZ0-00064203
n9:predkladatel
n10:ico%3A00064203
n3:aktivita
n15:I
n3:aktivity
I
n3:cisloPeriodika
11
n3:dodaniDat
n12:2013
n3:domaciTvurceVysledku
n11:7384874
n3:druhVysledku
n14:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
125500
n3:idVysledku
RIV/00064203:_____/12:8130
n3:jazykVysledku
n13:eng
n3:klicovaSlova
mellitus; risk; metaanalysis; antibodies; infection; europe; trends; life
n3:klicoveSlovo
n5:metaanalysis n5:infection n5:europe n5:life n5:risk n5:trends n5:mellitus n5:antibodies
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[B96E3AE8A3B1]
n3:nazevZdroje
Diabetes Care
n3:obor
n17:FB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
33
n3:rokUplatneniVysledku
n12:2012
n3:svazekPeriodika
35
n3:tvurceVysledku
Karavanaki, K. Benson, V. Salem, M. Ludvigsson, J. Strotmeyer, ES Cinek, Ondřej Harrild, K. Rabiei, S. Svensson, J. Sipetic, S. Wadsworth, EJK Radon, K. Gimeno, SG Patterson, CC Ionescu-Tirgoviste, C. Savilahti, E. de Beaufort, CE Rosenbauer, J. Chuang, LM Joner, G. Chetwynd, A. Urbonaite, B. Parslow, RC Ponsonby, A. L. Devoti, G. Memon, A. Brigis, G. Cardwell, CR Perez-Bravo, F. Stene, LC Goldacre, M. J. Pozzilli, P. Schober, E.
n3:wos
000311424100023
s:issn
0149-5992
s:numberOfPages
11