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Statements

Subject Item
n2:RIV%2F00064203%3A_____%2F12%3A8106%21RIV13-MZ0-00064203
rdf:type
skos:Concept n5:Vysledek
rdfs:seeAlso
http://www.ncbi.nlm.nih.gov/pubmed/22691100
dcterms:description
Enterovirus infections may be involved in the etiology of type 1 diabetes (T1D), which is strongly associated with certain human leukocyte antigen (HLA) class II haplotypes. Our aim was to assess whether HLA genotypes conferring varying degrees of risk for T1D were associated with enterovirus gut infections. From the general Norwegian population, 190 healthy infants at high-risk for T1D (DR4-DQ8/DR3-DQ2), and 383 infants without this genotype were identified. Non-DR4-DQ8/DR3-DQ2 genotypes were further categorized as conferring either an increased-to-moderate risk (DR4-DQ8 or DR3-DQ2), were protective (DQB1*06:02), or were neutral (all other genotypes). A total of 4626 monthly fecal samples taken between age 3 and 12mo were tested for enterovirus RNA using real-time PCR. Enterovirus prevalence was 11.5% among high-risk children, and 12.2% in other children (adjusted odds ratio: 1.23, p = 0.12). The prevalence was 11.3% in those with increased-to-moderate risk, 13.0% in the protective group, and 12.6% in the neutral group (likelihood ratio test, 3 d.f.: p = 0.37). In conclusion, there was no statistically significant association between HLA genotype and the occurrence of human enterovirus gut infections. Enterovirus infections may be involved in the etiology of type 1 diabetes (T1D), which is strongly associated with certain human leukocyte antigen (HLA) class II haplotypes. Our aim was to assess whether HLA genotypes conferring varying degrees of risk for T1D were associated with enterovirus gut infections. From the general Norwegian population, 190 healthy infants at high-risk for T1D (DR4-DQ8/DR3-DQ2), and 383 infants without this genotype were identified. Non-DR4-DQ8/DR3-DQ2 genotypes were further categorized as conferring either an increased-to-moderate risk (DR4-DQ8 or DR3-DQ2), were protective (DQB1*06:02), or were neutral (all other genotypes). A total of 4626 monthly fecal samples taken between age 3 and 12mo were tested for enterovirus RNA using real-time PCR. Enterovirus prevalence was 11.5% among high-risk children, and 12.2% in other children (adjusted odds ratio: 1.23, p = 0.12). The prevalence was 11.3% in those with increased-to-moderate risk, 13.0% in the protective group, and 12.6% in the neutral group (likelihood ratio test, 3 d.f.: p = 0.37). In conclusion, there was no statistically significant association between HLA genotype and the occurrence of human enterovirus gut infections.
dcterms:title
HLA-DRB1-DQA1-DQB1 Genotype and Frequency of Enterovirus in Longitudinal Monthly Fecal Samples from Healthy Infants HLA-DRB1-DQA1-DQB1 Genotype and Frequency of Enterovirus in Longitudinal Monthly Fecal Samples from Healthy Infants
skos:prefLabel
HLA-DRB1-DQA1-DQB1 Genotype and Frequency of Enterovirus in Longitudinal Monthly Fecal Samples from Healthy Infants HLA-DRB1-DQA1-DQB1 Genotype and Frequency of Enterovirus in Longitudinal Monthly Fecal Samples from Healthy Infants
skos:notation
RIV/00064203:_____/12:8106!RIV13-MZ0-00064203
n5:predkladatel
n6:ico%3A00064203
n3:aktivita
n14:I n14:P
n3:aktivity
I, P(NT11465)
n3:cisloPeriodika
3
n3:dodaniDat
n10:2013
n3:domaciTvurceVysledku
n13:7384874
n3:druhVysledku
n17:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
139209
n3:idVysledku
RIV/00064203:_____/12:8106
n3:jazykVysledku
n19:eng
n3:klicovaSlova
dependent diabetes-mellitus; beta-cell autoimmunity; encephalomyocarditis virus; young daisy; hla; infections; risk; iddm; genetics; antigens
n3:klicoveSlovo
n4:young%20daisy n4:iddm n4:encephalomyocarditis%20virus n4:beta-cell%20autoimmunity n4:hla n4:risk n4:genetics n4:antigens n4:dependent%20diabetes-mellitus n4:infections
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[B98EC0F04FF4]
n3:nazevZdroje
Viral Immunology
n3:obor
n8:EC
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:projekt
n12:NT11465
n3:rokUplatneniVysledku
n10:2012
n3:svazekPeriodika
25
n3:tvurceVysledku
Cinek, Ondřej Rasmussen, T. Tapia, G. Stene, LC Witso, E. Ronningen, KS
n3:wos
000305285000003
s:issn
0882-8245
s:numberOfPages
6