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Statements

Subject Item
n2:RIV%2F00064203%3A_____%2F12%3A8074%21RIV13-MZ0-00064203
rdf:type
skos:Concept n7:Vysledek
rdfs:seeAlso
http://www.ncbi.nlm.nih.gov/pubmed/22578954
dcterms:description
Positive evolutionary pressure has apparently preserved the ability to synthesize chemically authentic morphine, albeit in homeopathic concentrations, throughout animal phyla. Despite the establishment of a progressively rigorous and mechanistically focused historical literature extending from the mid 1970s to the mid 1980s that supported the expression of chemically authentic morphine by animal cellular and organ systems, prejudicial scepticism and early dismissal by scientists and clinicians most often obscured widespread acceptance of the biological importance and medical implications of endogenous morphine. The current critical paper presents and evaluates key recent coordinated studies in endogenous morphine research, highlighting those that have advanced our understanding of the functional roles of cognate alkaloid-selective mu(3) and mu(4) opiate receptors. We propose that the expression of endogenous morphine by animal and human cells is designed to mediate homeopathic regulation of metabolic activity via activation of cognate mu(3) and mu(4) receptors that serve as transductive conduits for short-circuit Ca++ fluxes. The implications of endogenous morphine coupling to nitric oxide regulation of mitochondrial function, with special reference to the cardiovascular system, are now formulated after many years of neglect. Positive evolutionary pressure has apparently preserved the ability to synthesize chemically authentic morphine, albeit in homeopathic concentrations, throughout animal phyla. Despite the establishment of a progressively rigorous and mechanistically focused historical literature extending from the mid 1970s to the mid 1980s that supported the expression of chemically authentic morphine by animal cellular and organ systems, prejudicial scepticism and early dismissal by scientists and clinicians most often obscured widespread acceptance of the biological importance and medical implications of endogenous morphine. The current critical paper presents and evaluates key recent coordinated studies in endogenous morphine research, highlighting those that have advanced our understanding of the functional roles of cognate alkaloid-selective mu(3) and mu(4) opiate receptors. We propose that the expression of endogenous morphine by animal and human cells is designed to mediate homeopathic regulation of metabolic activity via activation of cognate mu(3) and mu(4) receptors that serve as transductive conduits for short-circuit Ca++ fluxes. The implications of endogenous morphine coupling to nitric oxide regulation of mitochondrial function, with special reference to the cardiovascular system, are now formulated after many years of neglect.
dcterms:title
Endogenous Morphine: Up-to-Date Review 2011 Endogenous Morphine: Up-to-Date Review 2011
skos:prefLabel
Endogenous Morphine: Up-to-Date Review 2011 Endogenous Morphine: Up-to-Date Review 2011
skos:notation
RIV/00064203:_____/12:8074!RIV13-MZ0-00064203
n7:predkladatel
n8:ico%3A00064203
n3:aktivita
n13:I n13:N
n3:aktivity
I, N
n3:cisloPeriodika
2
n3:dodaniDat
n16:2013
n3:domaciTvurceVysledku
n14:3878392
n3:druhVysledku
n15:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
134276
n3:idVysledku
RIV/00064203:_____/12:8074
n3:jazykVysledku
n10:eng
n3:klicovaSlova
endogenous morphine; dopamine; catecholamine; nitric oxide; nitric oxide synthase; benzylisoquinoline alkaloid biosynthesis; oxide-coupled regulation; white blood-cells; nitric-oxide; opium poppy; in-vitro; mitochondrial processes; norcoclaurine synthase; ganglionic morphine; neuroblastoma-cells
n3:klicoveSlovo
n4:dopamine n4:catecholamine n4:nitric%20oxide%20synthase n4:nitric%20oxide n4:oxide-coupled%20regulation n4:norcoclaurine%20synthase n4:nitric-oxide n4:ganglionic%20morphine n4:white%20blood-cells n4:neuroblastoma-cells n4:benzylisoquinoline%20alkaloid%20biosynthesis n4:endogenous%20morphine n4:opium%20poppy n4:mitochondrial%20processes n4:in-vitro
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[C4428053152B]
n3:nazevZdroje
Folia Biologica
n3:obor
n12:CE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n16:2012
n3:svazekPeriodika
58
n3:tvurceVysledku
Kream, R. M. Ptacek, R. Stefano, GB Kuželová, Hana
n3:wos
000303140600001
s:issn
0015-5500
s:numberOfPages
8