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Statements

Subject Item
n2:RIV%2F00064203%3A_____%2F12%3A8064%21RIV13-MZ0-00064203
rdf:type
n10:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1111/j.1365-3083.2011.02637.x
dcterms:description
Expression features of genetic landscape which predispose an individual to the type 1 diabetes are poorly understood. We addressed this question by comparing gene expression profile of freshly isolated peripheral blood mononuclear cells isolated from either patients with type 1 diabetes (T1D), or their first-degree relatives or healthy controls. Our aim was to establish whether a distinct type of prodiabetogenic gene expression pattern in the group of relatives of patients with T1D could be identified. Whole-genome expression profile of nine patients with T1D, their ten first-degree relatives and ten healthy controls was analysed using the human high-density expression microarray chip. Functional aspects of candidate genes were assessed using the MetaCore software. The highest number of differentially expressed genes (547) was found between the autoantibody-negative healthy relatives and the healthy controls. Some of them represent genes critically involved in the regulation of innate immune responses such as TLR signalling and CCR3 signalling in eosinophiles, humoral immune reactions such as BCR pathway, costimulation and cytokine responses mediated by CD137, CD40 and CD28 signalling and IL-1 proinflammatory pathway. Our data demonstrate that expression profile of healthy relatives of patients with T1D is clearly distinct from the pattern found in the healthy controls. That especially concerns differential activation status of genes and signalling pathways involved in proinflammatory processes and those of innate immunity and humoral reactivity. Thus, we posit that the study of the healthy relatives gene expression pattern is instrumental for the identification of novel markers associated with the development of diabetes. Expression features of genetic landscape which predispose an individual to the type 1 diabetes are poorly understood. We addressed this question by comparing gene expression profile of freshly isolated peripheral blood mononuclear cells isolated from either patients with type 1 diabetes (T1D), or their first-degree relatives or healthy controls. Our aim was to establish whether a distinct type of prodiabetogenic gene expression pattern in the group of relatives of patients with T1D could be identified. Whole-genome expression profile of nine patients with T1D, their ten first-degree relatives and ten healthy controls was analysed using the human high-density expression microarray chip. Functional aspects of candidate genes were assessed using the MetaCore software. The highest number of differentially expressed genes (547) was found between the autoantibody-negative healthy relatives and the healthy controls. Some of them represent genes critically involved in the regulation of innate immune responses such as TLR signalling and CCR3 signalling in eosinophiles, humoral immune reactions such as BCR pathway, costimulation and cytokine responses mediated by CD137, CD40 and CD28 signalling and IL-1 proinflammatory pathway. Our data demonstrate that expression profile of healthy relatives of patients with T1D is clearly distinct from the pattern found in the healthy controls. That especially concerns differential activation status of genes and signalling pathways involved in proinflammatory processes and those of innate immunity and humoral reactivity. Thus, we posit that the study of the healthy relatives gene expression pattern is instrumental for the identification of novel markers associated with the development of diabetes.
dcterms:title
Healthy First-Degree Relatives of Patients with Type 1 Diabetes Exhibit Significant Differences in Basal Gene Expression Pattern of Immunocompetent Cells Compared to Controls: Expression Pattern as Predeterminant of Autoimmune Diabetes Healthy First-Degree Relatives of Patients with Type 1 Diabetes Exhibit Significant Differences in Basal Gene Expression Pattern of Immunocompetent Cells Compared to Controls: Expression Pattern as Predeterminant of Autoimmune Diabetes
skos:prefLabel
Healthy First-Degree Relatives of Patients with Type 1 Diabetes Exhibit Significant Differences in Basal Gene Expression Pattern of Immunocompetent Cells Compared to Controls: Expression Pattern as Predeterminant of Autoimmune Diabetes Healthy First-Degree Relatives of Patients with Type 1 Diabetes Exhibit Significant Differences in Basal Gene Expression Pattern of Immunocompetent Cells Compared to Controls: Expression Pattern as Predeterminant of Autoimmune Diabetes
skos:notation
RIV/00064203:_____/12:8064!RIV13-MZ0-00064203
n10:predkladatel
n19:ico%3A00064203
n3:aktivita
n11:P n11:I n11:Z
n3:aktivity
I, P(2B06019), P(2B08066), Z(AV0Z50520514)
n3:cisloPeriodika
2
n3:dodaniDat
n4:2013
n3:domaciTvurceVysledku
n5:7276990 n5:7396260 n5:2433435 n5:9153926 n5:9149996 n5:3081702 n5:1374176
n3:druhVysledku
n13:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
138720
n3:idVysledku
RIV/00064203:_____/12:8064
n3:jazykVysledku
n8:eng
n3:klicovaSlova
blood mononuclear-cells; peripheral-blood; t-cells; microarray analysis; in-vitro; disease; mellitus; onset; risk; pathogenesis
n3:klicoveSlovo
n12:microarray%20analysis n12:pathogenesis n12:peripheral-blood n12:disease n12:t-cells n12:in-vitro n12:onset n12:mellitus n12:risk n12:blood%20mononuclear-cells
n3:kodStatuVydavatele
NO - Norské království
n3:kontrolniKodProRIV
[0840113B12E3]
n3:nazevZdroje
Scandinavian Journal of Immunology
n3:obor
n14:EC
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
15
n3:projekt
n9:2B08066 n9:2B06019
n3:rokUplatneniVysledku
n4:2012
n3:svazekPeriodika
75
n3:tvurceVysledku
Blatny, R. Halbhuber, Z. Obermannová, Barbora Včeláková, Jana Krivjanska, M. Filipp, D. Koloušková, Stanislava Stavikova, V. Petruželková, Lenka Piťhová, Pavlína Šumník, Zdeněk Kolar, M. Hubáčková, Miluše Neuwirth, A. Štechová, Kateřina
n3:wos
000298985400010
n3:zamer
n18:AV0Z50520514
s:issn
0300-9475
s:numberOfPages
10