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Statements

Subject Item
n2:RIV%2F00064203%3A_____%2F12%3A8016%21RIV13-MZ0-00064203
rdf:type
skos:Concept n9:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1089/gtmb.2011.0129
dcterms:description
Aims: The aim of the study was to investigate genetic variants predicting cardiovascular events in patients with dyslipidemia and compare its relationship with common risk factors including hyperlipidemia, metabolic syndrome, history of acute myocardial infarction, thrombosis, obesity, and smoking. Materials and Methods: Five hundred two individuals divided into six groups corresponding with the risk factors and a control group of normolypidemic patients were analyzed for the presence of eight mutations and polymorphisms (endothelial nitric oxide synthase -786T -> C and G894T; lymphotoxin A C804A; angiotensin-converting enzyme [ACE] ins/del; human platelet antigen 1 a/b; beta-fibrinogen -455G -> A; apolipoprotein B [ApoB] R3500Q; APOE E2/E3/E4) using the ViennaLab CVD Strip assay. Results: ACE deletions are the most frequent genetic variants in risk groups of dyslipidemic patients (from 58% in cardiovascular events to 51% in smokers). We found a strong relationship between genetic variants and risk factors. G894T is significantly associated with smoking (value of odds ratio [OR] = 1.62, p = 0.04), and ACE deletions are negatively associated with cardiovascular events (OR = 0.62, p = 0.03). Conclusion: Significant associations between genetic variants predicting cardiovascular events and common risk factors in dyslipidemic patients were found. Aims: The aim of the study was to investigate genetic variants predicting cardiovascular events in patients with dyslipidemia and compare its relationship with common risk factors including hyperlipidemia, metabolic syndrome, history of acute myocardial infarction, thrombosis, obesity, and smoking. Materials and Methods: Five hundred two individuals divided into six groups corresponding with the risk factors and a control group of normolypidemic patients were analyzed for the presence of eight mutations and polymorphisms (endothelial nitric oxide synthase -786T -> C and G894T; lymphotoxin A C804A; angiotensin-converting enzyme [ACE] ins/del; human platelet antigen 1 a/b; beta-fibrinogen -455G -> A; apolipoprotein B [ApoB] R3500Q; APOE E2/E3/E4) using the ViennaLab CVD Strip assay. Results: ACE deletions are the most frequent genetic variants in risk groups of dyslipidemic patients (from 58% in cardiovascular events to 51% in smokers). We found a strong relationship between genetic variants and risk factors. G894T is significantly associated with smoking (value of odds ratio [OR] = 1.62, p = 0.04), and ACE deletions are negatively associated with cardiovascular events (OR = 0.62, p = 0.03). Conclusion: Significant associations between genetic variants predicting cardiovascular events and common risk factors in dyslipidemic patients were found.
dcterms:title
Correlation Between Common Genetic Variants and Risk Factors Associated with Prediction of Cardiovascular Diseases in Dyslipidemic Patients Correlation Between Common Genetic Variants and Risk Factors Associated with Prediction of Cardiovascular Diseases in Dyslipidemic Patients
skos:prefLabel
Correlation Between Common Genetic Variants and Risk Factors Associated with Prediction of Cardiovascular Diseases in Dyslipidemic Patients Correlation Between Common Genetic Variants and Risk Factors Associated with Prediction of Cardiovascular Diseases in Dyslipidemic Patients
skos:notation
RIV/00064203:_____/12:8016!RIV13-MZ0-00064203
n9:predkladatel
n10:ico%3A00064203
n4:aktivita
n18:I
n4:aktivity
I
n4:cisloPeriodika
3
n4:dodaniDat
n12:2013
n4:domaciTvurceVysledku
n8:4014367 n8:7328486 n8:4045238
n4:druhVysledku
n17:J
n4:duvernostUdaju
n15:S
n4:entitaPredkladatele
n11:predkladatel
n4:idSjednocenehoVysledku
128854
n4:idVysledku
RIV/00064203:_____/12:8016
n4:jazykVysledku
n7:eng
n4:klicovaSlova
angiotensin-converting enzyme; ischemic-heart-disease; coronary-artery-disease; apolipoprotein-b gene; beta-fibrinogen gene; myocardial-infarction; deletion polymorphism; atherosclerosis risk; hypercholesterolemia; metaanalysis
n4:klicoveSlovo
n5:coronary-artery-disease n5:beta-fibrinogen%20gene n5:apolipoprotein-b%20gene n5:hypercholesterolemia n5:ischemic-heart-disease n5:atherosclerosis%20risk n5:myocardial-infarction n5:deletion%20polymorphism n5:metaanalysis n5:angiotensin-converting%20enzyme
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[9F57B32723C1]
n4:nazevZdroje
Genetic Testing and Molecular Biomarkers
n4:obor
n16:EB
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
5
n4:rokUplatneniVysledku
n12:2012
n4:svazekPeriodika
16
n4:tvurceVysledku
Kolářová, Jitka Kotrčová, Kateřina Průša, Richard Kotaška, Karel Čepová, Jana
n4:wos
000301777000011
s:issn
1945-0265
s:numberOfPages
5