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Statements

Subject Item
n2:RIV%2F00064203%3A_____%2F12%3A7991%21RIV13-MZ0-00064203
rdf:type
n5:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1038/bmt.2011.78
dcterms:description
Infertility is a major late effect in patients receiving haematopoietic stem cell transplantation (HSCT). The aim of this study was to determine the proportion of patients having fertility impairment after allogeneic HSCT in childhood/adolescence and to identify the potential risk factors. Treatment and fertility data of paediatric patients with malignant and non-malignant diseases treated with allogeneic HSCT between 2000 and 2005 were collected from seven European centres. Data were obtained for 138 female and 206 male patients after a median follow-up of 6 years (range 3-12). The patients' median age was 13 years (range 4-28) at the time of HSCT and 19 (range 12-35) years at the time of the enquiry. Seven children were born to the overall group, all at term and healthy. Fertility impairment was suspected in 69% males and 83% females. Start of treatment at age >= 13 years was a risk factor in females (odds ratio (OR) 4.7; 95% confidence interval (CI), 1.5 to 14.9), whereas pre-pubertal therapy was a risk factor in males (OR 0.4; 95% CI, 0.2 to 0.8). The major treatment-related risk factors were BU in females (OR 47.4; 95% CI, 5.4 to 418.1) and TBI in males (OR 7.7; 95% CI, 2.3 to 25.4). In light of the significant proportion of HSCT patients reviewed with impaired fertility, fertility conservation procedures should be considered for all patients undergoing HSCT, particularly those receiving TBI or BU-based preparative regimens. Infertility is a major late effect in patients receiving haematopoietic stem cell transplantation (HSCT). The aim of this study was to determine the proportion of patients having fertility impairment after allogeneic HSCT in childhood/adolescence and to identify the potential risk factors. Treatment and fertility data of paediatric patients with malignant and non-malignant diseases treated with allogeneic HSCT between 2000 and 2005 were collected from seven European centres. Data were obtained for 138 female and 206 male patients after a median follow-up of 6 years (range 3-12). The patients' median age was 13 years (range 4-28) at the time of HSCT and 19 (range 12-35) years at the time of the enquiry. Seven children were born to the overall group, all at term and healthy. Fertility impairment was suspected in 69% males and 83% females. Start of treatment at age >= 13 years was a risk factor in females (odds ratio (OR) 4.7; 95% confidence interval (CI), 1.5 to 14.9), whereas pre-pubertal therapy was a risk factor in males (OR 0.4; 95% CI, 0.2 to 0.8). The major treatment-related risk factors were BU in females (OR 47.4; 95% CI, 5.4 to 418.1) and TBI in males (OR 7.7; 95% CI, 2.3 to 25.4). In light of the significant proportion of HSCT patients reviewed with impaired fertility, fertility conservation procedures should be considered for all patients undergoing HSCT, particularly those receiving TBI or BU-based preparative regimens.
dcterms:title
Fertility after allogeneic haematopoietic stem cell transplantation in childhood and adolescence Fertility after allogeneic haematopoietic stem cell transplantation in childhood and adolescence
skos:prefLabel
Fertility after allogeneic haematopoietic stem cell transplantation in childhood and adolescence Fertility after allogeneic haematopoietic stem cell transplantation in childhood and adolescence
skos:notation
RIV/00064203:_____/12:7991!RIV13-MZ0-00064203
n5:predkladatel
n10:ico%3A00064203
n3:aktivita
n16:I
n3:aktivity
I
n3:cisloPeriodika
2
n3:dodaniDat
n15:2013
n3:domaciTvurceVysledku
n18:3239837
n3:druhVysledku
n17:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
136388
n3:idVysledku
RIV/00064203:_____/12:7991
n3:jazykVysledku
n4:eng
n3:klicovaSlova
allogeneic haematopoietic stem cell transplantation; cytotoxic therapy; pregnancy outcome; fertility; childhood; bone-marrow-transplantation; induced ovarian failure; breast-cancer; chemotherapy; radiotherapy; radiation; hormone; women
n3:klicoveSlovo
n6:pregnancy%20outcome n6:bone-marrow-transplantation n6:breast-cancer n6:induced%20ovarian%20failure n6:childhood n6:women n6:allogeneic%20haematopoietic%20stem%20cell%20transplantation n6:radiation n6:radiotherapy n6:hormone n6:cytotoxic%20therapy n6:chemotherapy n6:fertility
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[F8B2BC340C96]
n3:nazevZdroje
Bone Marrow Transplantation
n3:obor
n12:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
12
n3:rokUplatneniVysledku
n15:2012
n3:svazekPeriodika
47
n3:tvurceVysledku
Lawitschka, A. Hohmann, C. Keil, T. Holter, W. Keslová, Petra Rendtorff, R. Reinmuth, S. Borgmann-Staudt, A. Schuster, FR Strauss, G. Ehlert, K. Jarisch, A.
n3:wos
000300415100017
s:issn
0268-3369
s:numberOfPages
6