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Statements

Subject Item
n2:RIV%2F00064203%3A_____%2F12%3A7987%21RIV13-MZ0-00064203
rdf:type
skos:Concept n14:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1182/blood-2011-04-349688
dcterms:description
We investigated prospectively factors influencing the safety of hematopoietic stem cell (HSC) collection in 453 pediatric donors. The children in the study donated either BM or peripheral blood stem cells (PBSCs) according to center policy. A large variability in approach to donor issues was observed between the participating centers. Significant differences were observed between BM and PBSC donors regarding pain, blood allotransfusion, duration of hospital stay, and iron supplementation; however, differences between the groups undergoing BM vs PBSC donation preclude direct risk comparisons between the 2 procedures. The most common adverse event was pain, reported mainly by older children after BM harvest, but also observed after central venous catheter (CVC) placement for PBSC collection. With regard to severe adverse events, one patient (0.7%) developed a pneumothorax with hydrothorax after CVC placement for PBSC collection. The risk of allotransfusion after BM harvest was associated with a donor age of < 4 years and a BM harvest volume of > 20 mL/kg. Children < 4 years were at higher risk than older children for allotransfusion after BM harvest and there was a higher risk of complications from CVC placement before apheresis. We conclude that PBSC and BM collection are safe procedures in children. We investigated prospectively factors influencing the safety of hematopoietic stem cell (HSC) collection in 453 pediatric donors. The children in the study donated either BM or peripheral blood stem cells (PBSCs) according to center policy. A large variability in approach to donor issues was observed between the participating centers. Significant differences were observed between BM and PBSC donors regarding pain, blood allotransfusion, duration of hospital stay, and iron supplementation; however, differences between the groups undergoing BM vs PBSC donation preclude direct risk comparisons between the 2 procedures. The most common adverse event was pain, reported mainly by older children after BM harvest, but also observed after central venous catheter (CVC) placement for PBSC collection. With regard to severe adverse events, one patient (0.7%) developed a pneumothorax with hydrothorax after CVC placement for PBSC collection. The risk of allotransfusion after BM harvest was associated with a donor age of < 4 years and a BM harvest volume of > 20 mL/kg. Children < 4 years were at higher risk than older children for allotransfusion after BM harvest and there was a higher risk of complications from CVC placement before apheresis. We conclude that PBSC and BM collection are safe procedures in children.
dcterms:title
Risk of complications during hematopoietic stem cell collection in pediatric sibling donors: a prospective European Group for Blood and Marrow Transplantation Pediatric Diseases Working Party study Risk of complications during hematopoietic stem cell collection in pediatric sibling donors: a prospective European Group for Blood and Marrow Transplantation Pediatric Diseases Working Party study
skos:prefLabel
Risk of complications during hematopoietic stem cell collection in pediatric sibling donors: a prospective European Group for Blood and Marrow Transplantation Pediatric Diseases Working Party study Risk of complications during hematopoietic stem cell collection in pediatric sibling donors: a prospective European Group for Blood and Marrow Transplantation Pediatric Diseases Working Party study
skos:notation
RIV/00064203:_____/12:7987!RIV13-MZ0-00064203
n14:predkladatel
n15:ico%3A00064203
n3:aktivita
n12:I
n3:aktivity
I
n3:cisloPeriodika
12
n3:dodaniDat
n7:2013
n3:domaciTvurceVysledku
n8:1824139
n3:druhVysledku
n13:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
165682
n3:idVysledku
RIV/00064203:_____/12:7987
n3:jazykVysledku
n10:eng
n3:klicovaSlova
matched unrelated donors; bone-marrow; g-csf; allogeneic transplantation; adverse events; acute-leukemia; children; adolescents; safety; experience
n3:klicoveSlovo
n4:adverse%20events n4:allogeneic%20transplantation n4:safety n4:adolescents n4:experience n4:bone-marrow n4:children n4:acute-leukemia n4:matched%20unrelated%20donors n4:g-csf
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[6046756C662D]
n3:nazevZdroje
Blood
n3:obor
n11:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
24
n3:rokUplatneniVysledku
n7:2012
n3:svazekPeriodika
119
n3:tvurceVysledku
Rascon, J. Fagioli, F. Eyrich, M. Wachowiak, J. Messina, C. Labopin, M. Gozdzik, J. Diaz, M. A. Dreger, P. Matulová, Martina Yesilipek, M. A. Dalle, J. H Balduzzi, A. Hamladji, R. M. Hutt, D. Styczynski, J. Ehlert, K. Vermylen, C. Miano, M. Marktel, S. Gil, L. Badell, I. Dini, G. Peters, C.
n3:wos
000302121700031
s:issn
0006-4971
s:numberOfPages
8