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Statements

Subject Item
n2:RIV%2F00064203%3A_____%2F12%3A7983%21RIV13-MZ0-00064203
rdf:type
skos:Concept n15:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1093/annonc/mdr335
dcterms:description
Abstract: Background: The study aimed to investigate the role of medical history (skin warts, Candida albicans, herpetic lesions, heartburn, regurgitation) and medication use (for heartburn; for regurgitation; aspirin) in the aetiology of upper aerodigestive tract (UADT) cancer. Methods: A multicentre (10 European countries) case-control study [Alcohol-Related CAncers and GEnetic susceptibility (ARCAGE) project]. Results: There were 1779 cases of UADT cancer and 1993 controls. History of warts or C. albicans infection was associated with a reduced risk [odds ratio (OR) 0.80, 95% confidence interval (CI) 0.68-0.94 and OR 0.73, 95% CI 0.60-0.89, respectively] but there was no association with herpetic lesions, heartburn, regurgitation or medication for related symptoms. Regurgitation was associated with an increased risk for cancer of the oesophagus (OR 1.47, 95% CI 0.98-2.21). Regular aspirin use was not associated with risk of UADT cancer overall but was associated with a reduced risk for cancer of oesophagus (OR 0.51, 95% CI 0.28-0.96), hypopharynx (OR 0.53, 95% CI 0.28-1.02) and larynx (OR 0.74, 95% CI 0.54-1.01). Conclusions: A history of some infections appears to be a marker for decreased risk of UADT cancer. The role of medical history and medication use varied by UADT subsites with aspirin use associated with a decreased risk of oesophageal cancer and suggestive of a decreased risk of hypopharyngeal and laryngeal cancers. Abstract: Background: The study aimed to investigate the role of medical history (skin warts, Candida albicans, herpetic lesions, heartburn, regurgitation) and medication use (for heartburn; for regurgitation; aspirin) in the aetiology of upper aerodigestive tract (UADT) cancer. Methods: A multicentre (10 European countries) case-control study [Alcohol-Related CAncers and GEnetic susceptibility (ARCAGE) project]. Results: There were 1779 cases of UADT cancer and 1993 controls. History of warts or C. albicans infection was associated with a reduced risk [odds ratio (OR) 0.80, 95% confidence interval (CI) 0.68-0.94 and OR 0.73, 95% CI 0.60-0.89, respectively] but there was no association with herpetic lesions, heartburn, regurgitation or medication for related symptoms. Regurgitation was associated with an increased risk for cancer of the oesophagus (OR 1.47, 95% CI 0.98-2.21). Regular aspirin use was not associated with risk of UADT cancer overall but was associated with a reduced risk for cancer of oesophagus (OR 0.51, 95% CI 0.28-0.96), hypopharynx (OR 0.53, 95% CI 0.28-1.02) and larynx (OR 0.74, 95% CI 0.54-1.01). Conclusions: A history of some infections appears to be a marker for decreased risk of UADT cancer. The role of medical history and medication use varied by UADT subsites with aspirin use associated with a decreased risk of oesophageal cancer and suggestive of a decreased risk of hypopharyngeal and laryngeal cancers.
dcterms:title
Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: the ARCAGE study Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: the ARCAGE study
skos:prefLabel
Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: the ARCAGE study Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: the ARCAGE study
skos:notation
RIV/00064203:_____/12:7983!RIV13-MZ0-00064203
n15:predkladatel
n16:ico%3A00064203
n4:aktivita
n12:R n12:I
n4:aktivity
I, R
n4:cisloPeriodika
4
n4:dodaniDat
n6:2013
n4:domaciTvurceVysledku
n13:1963821
n4:druhVysledku
n11:J
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n14:predkladatel
n4:idSjednocenehoVysledku
166025
n4:idVysledku
RIV/00064203:_____/12:7983
n4:jazykVysledku
n8:eng
n4:klicovaSlova
aspirin use; epidemiology; gastroesophageal reflux; medical history; medication use; upper aerodigestive tract cancer; nonsteroidal antiinflammatory drugs; oral-cancer; human-papillomavirus; risk-factors; esophageal; aspirin; head
n4:klicoveSlovo
n5:medical%20history n5:gastroesophageal%20reflux n5:aspirin n5:human-papillomavirus n5:medication%20use n5:epidemiology n5:nonsteroidal%20antiinflammatory%20drugs n5:oral-cancer n5:head n5:esophageal n5:aspirin%20use n5:risk-factors n5:upper%20aerodigestive%20tract%20cancer
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[D1C95BF79535]
n4:nazevZdroje
Annals of Oncology
n4:obor
n10:FD
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
29
n4:rokUplatneniVysledku
n6:2012
n4:svazekPeriodika
23
n4:tvurceVysledku
Healy, CM Lagiou, A. Agudo, A. Thakker, NS Slamova, A. Thomson, P. Simonato, L. Talamini, R. McCartan, BE Castellsague, X. Macfarlane, GJ Pohlabeln, H. Benhamou, S. Marron, M. Znaor, A. Sloan, P. Brennan, P. Barzan, L. Kjaerheim, K. Ahrens, W. Richiardi, L. Macfarlane, TV Canova, C. Lagiou, P. Bouchardy, C. Plzák, Jan Merletti, F. Conway, DI McKinney, P. A.
n4:wos
000302298000035
s:issn
0923-7534
s:numberOfPages
8