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Subject Item
n2:RIV%2F00064203%3A_____%2F12%3A7982%21RIV13-MZ0-00064203
rdf:type
n8:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1152/ajpheart.00740.2011
dcterms:description
Marcus KA, Janousek J, Barends ME, Weijers G, de Korte C. L, Kupusta L. Synchronicity of systolic deformation in healthy pediatric and young adult subjects: a two-dimensional strain echocardiography study. Am J Physiol Heart Circ Physiol 302: H196-H205, 2012. First published October, 7, 2011; doi:10.1152/ajpheart.00740.2011.-Two-dimensional speckle tracking echocardiography (2DSTE) offers valuable information in the echocardiographic assessment of ventricular myocardial function. It enables the quantification and timing of systolic ventricular myocardial deformation. In addition, 2DSTE can be used to identify mechanical dyssynchrony, which is an important parameter in predicting the response to cardiac resynchronization therapy for heart failure. Detailed knowledge of normal timing of systolic deformation and its degree of synchronicity in children is lacking. We aimed to establish the normal timing of left ventricular myocardial systolic deformation using 2DSTE in a large cohort of healthy children and young adults. Transthoracic echocardiograms were acquired in 195 healthy subjects (139 children and 56 young adult <40 yr of age) and were retrospectively analyzed. Time to peak systolic longitudinal, circumferential, and radial strain was determined by means of speckle tracking. Strong, statistically significant relations between age as well as various anthropometric variables (e. g., heart rate) and timing of systolic deformation (P < 0.0001) were present. The extent of dyssynchronous deformation increased with age. This is the first report that establishes reference values per cardiac segment for time to peak systolic myocardial strain values in all three directions assessed with 2DSTE in a large pediatric and young adult cohort. We emphasize the need for using age-specific reference values as well as heart rate correction for the adequate interpretation of 2DSTE measurements. Marcus KA, Janousek J, Barends ME, Weijers G, de Korte C. L, Kupusta L. Synchronicity of systolic deformation in healthy pediatric and young adult subjects: a two-dimensional strain echocardiography study. Am J Physiol Heart Circ Physiol 302: H196-H205, 2012. First published October, 7, 2011; doi:10.1152/ajpheart.00740.2011.-Two-dimensional speckle tracking echocardiography (2DSTE) offers valuable information in the echocardiographic assessment of ventricular myocardial function. It enables the quantification and timing of systolic ventricular myocardial deformation. In addition, 2DSTE can be used to identify mechanical dyssynchrony, which is an important parameter in predicting the response to cardiac resynchronization therapy for heart failure. Detailed knowledge of normal timing of systolic deformation and its degree of synchronicity in children is lacking. We aimed to establish the normal timing of left ventricular myocardial systolic deformation using 2DSTE in a large cohort of healthy children and young adults. Transthoracic echocardiograms were acquired in 195 healthy subjects (139 children and 56 young adult <40 yr of age) and were retrospectively analyzed. Time to peak systolic longitudinal, circumferential, and radial strain was determined by means of speckle tracking. Strong, statistically significant relations between age as well as various anthropometric variables (e. g., heart rate) and timing of systolic deformation (P < 0.0001) were present. The extent of dyssynchronous deformation increased with age. This is the first report that establishes reference values per cardiac segment for time to peak systolic myocardial strain values in all three directions assessed with 2DSTE in a large pediatric and young adult cohort. We emphasize the need for using age-specific reference values as well as heart rate correction for the adequate interpretation of 2DSTE measurements.
dcterms:title
Synchronicity of systolic deformation in healthy pediatric and young adult subjects: a two-dimensional strain echocardiography study Synchronicity of systolic deformation in healthy pediatric and young adult subjects: a two-dimensional strain echocardiography study
skos:prefLabel
Synchronicity of systolic deformation in healthy pediatric and young adult subjects: a two-dimensional strain echocardiography study Synchronicity of systolic deformation in healthy pediatric and young adult subjects: a two-dimensional strain echocardiography study
skos:notation
RIV/00064203:_____/12:7982!RIV13-MZ0-00064203
n8:predkladatel
n18:ico%3A00064203
n3:aktivita
n14:I
n3:aktivity
I
n3:cisloPeriodika
1
n3:dodaniDat
n7:2013
n3:domaciTvurceVysledku
n17:2104946
n3:druhVysledku
n12:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
172829
n3:idVysledku
RIV/00064203:_____/12:7982
n3:jazykVysledku
n13:eng
n3:klicovaSlova
child; reference value; cardiac-resynchronization therapy; congenital heart-disease; left-ventricular mass; right-intraventricular dyssynchrony; of-cardiology-foundation; bundle-branch block; dilated cardiomyopathy; clinical-cardiology; myocardial strain; speckle-tracking
n3:klicoveSlovo
n4:right-intraventricular%20dyssynchrony n4:left-ventricular%20mass n4:congenital%20heart-disease n4:of-cardiology-foundation n4:speckle-tracking n4:cardiac-resynchronization%20therapy n4:clinical-cardiology n4:dilated%20cardiomyopathy n4:bundle-branch%20block n4:myocardial%20strain n4:child n4:reference%20value
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[D2E8A8FC72F8]
n3:nazevZdroje
American Journal of Physiology-Heart and Circulatory Physiology
n3:obor
n15:FA
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n7:2012
n3:svazekPeriodika
302
n3:tvurceVysledku
Weijers, G. Barends, ME Janoušek, Jan de Korte, CL Kapusta, L. Marcus, K. A.
n3:wos
000298643800019
s:issn
0363-6135
s:numberOfPages
10