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Statements

Subject Item
n2:RIV%2F00064203%3A_____%2F11%3A7485%21RIV12-MZ0-00064203
rdf:type
skos:Concept n11:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1155/2011/309068
dcterms:description
Background. Primary hyperparathyroidism (PHPT) is one of the most common endocrine conditions and is accompanied by hypertension and increased cardiovascular mortality. The purpose of this study was to evaluate the effect of parathyroidectomy on systolic and diastolic blood pressure (BP) in hypertensive patients with PHPT and whether hypertension occurs more frequently in PHPT than in control group. Methods. A total of 1020 patients with proved PHPT who underwent surgery were compared with with 1020 age, sex, BMI, and smoking status matched controls. We evaluated changes in serum calcium, parathyroid hormone (PTH), uric acid, and BP before and 6 months after surgery. Results. Parathyroidectomy corrected PHPT and resulted in a substantial fall in both mean systolic (150 +/- 3.8 to 138 +/- 3.6mmHg) and mean diastolic pressures (97 +/- 3 to 88 +/- 2.8mmHg) of the hypertensive subjects; P < .01. In these patients, PTH, calcium, and uric acid normalized. 726 patients from 1020 with PHPT (69.8%) were found to be hypertensive whilst only 489 (47.8%) from 1020 of our control group. Conclusion. Parathyroidectomy in hypertensive patients reduces systolic and diastolic BP. PHPT is accompanied by a variety of metabolic complications, which are a risk factor for hypertension, and parathyroidectomy can improve these metabolic complications. Background. Primary hyperparathyroidism (PHPT) is one of the most common endocrine conditions and is accompanied by hypertension and increased cardiovascular mortality. The purpose of this study was to evaluate the effect of parathyroidectomy on systolic and diastolic blood pressure (BP) in hypertensive patients with PHPT and whether hypertension occurs more frequently in PHPT than in control group. Methods. A total of 1020 patients with proved PHPT who underwent surgery were compared with with 1020 age, sex, BMI, and smoking status matched controls. We evaluated changes in serum calcium, parathyroid hormone (PTH), uric acid, and BP before and 6 months after surgery. Results. Parathyroidectomy corrected PHPT and resulted in a substantial fall in both mean systolic (150 +/- 3.8 to 138 +/- 3.6mmHg) and mean diastolic pressures (97 +/- 3 to 88 +/- 2.8mmHg) of the hypertensive subjects; P < .01. In these patients, PTH, calcium, and uric acid normalized. 726 patients from 1020 with PHPT (69.8%) were found to be hypertensive whilst only 489 (47.8%) from 1020 of our control group. Conclusion. Parathyroidectomy in hypertensive patients reduces systolic and diastolic BP. PHPT is accompanied by a variety of metabolic complications, which are a risk factor for hypertension, and parathyroidectomy can improve these metabolic complications.
dcterms:title
Improvement of Hypertension after Parathyroidectomy of Patients Suffering from Primary Hyperparathyroidism Improvement of Hypertension after Parathyroidectomy of Patients Suffering from Primary Hyperparathyroidism
skos:prefLabel
Improvement of Hypertension after Parathyroidectomy of Patients Suffering from Primary Hyperparathyroidism Improvement of Hypertension after Parathyroidectomy of Patients Suffering from Primary Hyperparathyroidism
skos:notation
RIV/00064203:_____/11:7485!RIV12-MZ0-00064203
n11:predkladatel
n18:ico%3A00064203
n3:aktivita
n17:Z n17:I
n3:aktivity
I, Z(MSM0021620807)
n3:cisloPeriodika
309068
n3:dodaniDat
n12:2012
n3:domaciTvurceVysledku
n13:8941602 n13:1983873 n13:8057230
n3:druhVysledku
n7:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
203948
n3:idVysledku
RIV/00064203:_____/11:7485
n3:jazykVysledku
n4:eng
n3:klicovaSlova
Plasma-renin activity; blood-pressure; cardiovascular-disease; hormone; prevalence; humans
n3:klicoveSlovo
n5:Plasma-renin%20activity n5:cardiovascular-disease n5:hormone n5:blood-pressure n5:prevalence n5:humans
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[E03D396B28AB]
n3:nazevZdroje
International Journal of Endocrinology
n3:obor
n6:FB
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n12:2011
n3:svazekPeriodika
2011
n3:tvurceVysledku
Libánský, Petr Broulik, P. Broulikova, A. Adámek, Svatopluk Kubinyi, J. Broulikova, K. Tvrdoň, Jiří
n3:wos
000289097600001
n3:zamer
n14:MSM0021620807
s:issn
1687-8337
s:numberOfPages
6