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Statements

Subject Item
n2:RIV%2F00064203%3A_____%2F11%3A7156%21RIV12-MZ0-00064203
rdf:type
skos:Concept n16:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.3109/09513590.2010.508851
dcterms:description
The aim of the presented study is to evaluate metabolic features in adolescents with polycystic ovary syndrome (PCOS) in comparison with age-and BMI-matched subjects. Forty-three adolescents with PCOS according to ESHRE criteria were prospectively evaluated and compared with 48 control subjects. Blood sampling was done in the early follicular phase of menstrual cycle, between 1st and 5th day, for plasma glucose, total and high-density lipoprotein (HDL)-cholesterol, triglycerides, insulin and C peptide. The diagnosis of metabolic syndrome was done according to IDF adolescent criteria. Adolescents with PCOS have increased low-density lipoprotein (LDL)-cholesterol (p < 0.002), decreased HDL-cholesterol (p < 0.0007) and increased C peptide levels (p < 0.02) in comparison with healthy adolescents. Total cholesterol, triglycerides, fasting blood glucose, fasting insulin, HOMA-IR, waist-to-hip ratio, systolic and diastolic blood pressure did not differ between the groups. There was no difference when we compared the prevalence of adolescents with at least one feature of metabolic syndrome between PCOS (17 from 43) and healthy controls (27 from 48). In conclusion, adolescents with PCOS have less favourable blood lipid profiles with higher LDL-cholesterol and lower levels of HDL-cholesterol and are more insulin resistant than their healthy counterparts having higher fasting C peptide levels. The aim of the presented study is to evaluate metabolic features in adolescents with polycystic ovary syndrome (PCOS) in comparison with age-and BMI-matched subjects. Forty-three adolescents with PCOS according to ESHRE criteria were prospectively evaluated and compared with 48 control subjects. Blood sampling was done in the early follicular phase of menstrual cycle, between 1st and 5th day, for plasma glucose, total and high-density lipoprotein (HDL)-cholesterol, triglycerides, insulin and C peptide. The diagnosis of metabolic syndrome was done according to IDF adolescent criteria. Adolescents with PCOS have increased low-density lipoprotein (LDL)-cholesterol (p < 0.002), decreased HDL-cholesterol (p < 0.0007) and increased C peptide levels (p < 0.02) in comparison with healthy adolescents. Total cholesterol, triglycerides, fasting blood glucose, fasting insulin, HOMA-IR, waist-to-hip ratio, systolic and diastolic blood pressure did not differ between the groups. There was no difference when we compared the prevalence of adolescents with at least one feature of metabolic syndrome between PCOS (17 from 43) and healthy controls (27 from 48). In conclusion, adolescents with PCOS have less favourable blood lipid profiles with higher LDL-cholesterol and lower levels of HDL-cholesterol and are more insulin resistant than their healthy counterparts having higher fasting C peptide levels.
dcterms:title
Metabolic syndrome in adolescents with polycystic ovary syndrome Metabolic syndrome in adolescents with polycystic ovary syndrome
skos:prefLabel
Metabolic syndrome in adolescents with polycystic ovary syndrome Metabolic syndrome in adolescents with polycystic ovary syndrome
skos:notation
RIV/00064203:_____/11:7156!RIV12-MZ0-00064203
n16:predkladatel
n18:ico%3A00064203
n3:aktivita
n7:I
n3:aktivity
I
n3:cisloPeriodika
10
n3:dodaniDat
n6:2012
n3:domaciTvurceVysledku
n12:8617090
n3:druhVysledku
n8:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
211679
n3:idVysledku
RIV/00064203:_____/11:7156
n3:jazykVysledku
n10:eng
n3:klicovaSlova
Polycystic ovary syndrome; metabolic syndrome; insulin resistance; obesity; insulin-resistance; obese adolescents; prevalence; women; pcos; risk
n3:klicoveSlovo
n4:obese%20adolescents n4:pcos n4:metabolic%20syndrome n4:prevalence n4:obesity n4:insulin%20resistance n4:Polycystic%20ovary%20syndrome n4:women n4:risk n4:insulin-resistance
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[6E6F8C15B58D]
n3:nazevZdroje
Gynecological Endocrinology
n3:obor
n14:FK
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n6:2011
n3:svazekPeriodika
27
n3:tvurceVysledku
Vrbikova, J. Sedlackova, B. Zamrazilova, H. Šnajderová, Marta
n3:wos
000295617600016
s:issn
0951-3590
s:numberOfPages
3