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Statements

Subject Item
n2:RIV%2F00064203%3A_____%2F11%3A7032%21RIV12-MZ0-00064203
rdf:type
n9:Vysledek skos:Concept
rdfs:seeAlso
http://www.ncbi.nlm.nih.gov/pubmed/21382126
dcterms:description
Aim: Obstructive uropathies (OU) in childhood constitute one of the major causes of chronic renal insufficiency. Transforming growth factor-beta 1 (TGF-beta 1) is considered to be the major fibrogenic growth factor. The aim of the present study was to investigate urinary TGF-beta 1 levels in children with obstructive and non-obstructive uropathies (NOU). Methods: This study involved 19 children with OU, 11 children with non-obstructive hydronephrosis and 21 healthy children. Urinary TGF-beta 1, proteinuria, microalbuminuria and urinary alpha 1-microglobulin were measured, and renal function was assesed. The results were statistically analyzed. Results: Mean urinary TGF-beta 1 concentrations in patients with OU were significantly higher than those with NOU (4.14 +/- 0.67 creatinine vs 1.80 +/- 1 0.24 pg/mmol creatinine, P < 0.05) and healthy controls (1.66 +/- 0.28 pg/mmol creatinine, P < 0.05). Positive correlations of urinary TGF-beta 1 concentrations with proteinuria (r = 0.87, P < 0.0001) and urinary alpha 1-microglobulin (r = 0.82, P = 0.0002) were found in patients with OU. Conclusion: Children with OU have higher urinary TGF-beta 1 than children with NOU. Urinary TGF-beta 1 may be a useful non-invasive tool for the differential diagnosis between OU and NOU in children. A positive correlation of TGF-beta 1 with markers of renal tissue damage in patients with OU was found. Aim: Obstructive uropathies (OU) in childhood constitute one of the major causes of chronic renal insufficiency. Transforming growth factor-beta 1 (TGF-beta 1) is considered to be the major fibrogenic growth factor. The aim of the present study was to investigate urinary TGF-beta 1 levels in children with obstructive and non-obstructive uropathies (NOU). Methods: This study involved 19 children with OU, 11 children with non-obstructive hydronephrosis and 21 healthy children. Urinary TGF-beta 1, proteinuria, microalbuminuria and urinary alpha 1-microglobulin were measured, and renal function was assesed. The results were statistically analyzed. Results: Mean urinary TGF-beta 1 concentrations in patients with OU were significantly higher than those with NOU (4.14 +/- 0.67 creatinine vs 1.80 +/- 1 0.24 pg/mmol creatinine, P < 0.05) and healthy controls (1.66 +/- 0.28 pg/mmol creatinine, P < 0.05). Positive correlations of urinary TGF-beta 1 concentrations with proteinuria (r = 0.87, P < 0.0001) and urinary alpha 1-microglobulin (r = 0.82, P = 0.0002) were found in patients with OU. Conclusion: Children with OU have higher urinary TGF-beta 1 than children with NOU. Urinary TGF-beta 1 may be a useful non-invasive tool for the differential diagnosis between OU and NOU in children. A positive correlation of TGF-beta 1 with markers of renal tissue damage in patients with OU was found.
dcterms:title
Urinary transforming growth factor-beta 1 in children with obstructive uropathy Urinary transforming growth factor-beta 1 in children with obstructive uropathy
skos:prefLabel
Urinary transforming growth factor-beta 1 in children with obstructive uropathy Urinary transforming growth factor-beta 1 in children with obstructive uropathy
skos:notation
RIV/00064203:_____/11:7032!RIV12-MZ0-00064203
n9:predkladatel
n10:ico%3A00064203
n3:aktivita
n8:I n8:Z
n3:aktivity
I, Z(MZ0FNM2005)
n3:cisloPeriodika
6
n3:dodaniDat
n4:2012
n3:domaciTvurceVysledku
n5:4550315 n5:2412721 n5:2917718 n5:2905922 n5:7517890 n5:5309050 n5:3057232
n3:druhVysledku
n12:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
237065
n3:idVysledku
RIV/00064203:_____/11:7032
n3:jazykVysledku
n19:eng
n3:klicovaSlova
alpha 1-microglobulin; microalbuminuria; obstructive uropathy; proteinuria; transforming growth factor-beta 1; ureteropelvic junction obstruction; epidermal-growth-factor; tract obstruction; congenital hydronephrosis; transforming-growth-factor-beta(1); nephropathy; kidney; system
n3:klicoveSlovo
n11:proteinuria n11:tract%20obstruction n11:obstructive%20uropathy n11:ureteropelvic%20junction%20obstruction n11:system n11:alpha%201-microglobulin n11:congenital%20hydronephrosis n11:kidney n11:microalbuminuria n11:epidermal-growth-factor n11:transforming%20growth%20factor-beta%201 n11:transforming-growth-factor-beta%281%29 n11:nephropathy
n3:kodStatuVydavatele
AU - Australské společenství
n3:kontrolniKodProRIV
[5F52F776FB71]
n3:nazevZdroje
Nephrology
n3:obor
n17:FP
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
8
n3:rokUplatneniVysledku
n4:2011
n3:svazekPeriodika
16
n3:tvurceVysledku
Bronský, Jiří Seeman, Tomáš Pechová, Marta Janda, Jan Dvořáková, Hana Marie Matoušovic, Karel Bláhová, Květa Zieg, Jakub
n3:wos
000293240900009
n3:zamer
n16:MZ0FNM2005
s:issn
1320-5358
s:numberOfPages
4