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Statements

Subject Item
n2:RIV%2F00064203%3A_____%2F11%3A6983%21RIV12-MZ0-00064203
rdf:type
skos:Concept n15:Vysledek
rdfs:seeAlso
http://www.ncbi.nlm.nih.gov/pubmed/21451365
dcterms:description
The majority of lymphoblastic (precursor cell) neoplasms presents as leukemias. Consequently, the guidelines for lineage determination and subtyping of precursor cell neoplasms were primarily established for flow cytometry methods. Large-scale studies of nonleukemic lymphoblastic lymphomas are lacking so far. We analyzed a large series of pediatric patients with lymphoblastic lymphoma treated within a prospective randomized trial (the Euro-LB 02 study). Among 193 lymphomas, in which a detailed immunohistochemical analysis was carried out, there were several unusual and diagnostically challenging morphologic and immunophenotypical variants. These included 11 lymphomas with mixed phenotypes expressing markers of at least 2 hematopoietic lineages, 7 terminal deoxynucleotide transferase-negative lymphoblastic lymphomas, and 3 undifferentiated hematopoietic neoplasms that could not be assigned to any lineage with certainty. Our data indicate that World Health Organzation guidelines for lineage determination and subtyping of precursor cell leukemia need to be adapted before they can be applied to immunohistochemical diagnosis of lymphoma. Using the experience from this cohort we suggest a resource-saving diagnostic staining panel for the immunohistochemical analysis of precursor cell neoplasms in formalin-fixed paraffin-embedded tissue. The majority of lymphoblastic (precursor cell) neoplasms presents as leukemias. Consequently, the guidelines for lineage determination and subtyping of precursor cell neoplasms were primarily established for flow cytometry methods. Large-scale studies of nonleukemic lymphoblastic lymphomas are lacking so far. We analyzed a large series of pediatric patients with lymphoblastic lymphoma treated within a prospective randomized trial (the Euro-LB 02 study). Among 193 lymphomas, in which a detailed immunohistochemical analysis was carried out, there were several unusual and diagnostically challenging morphologic and immunophenotypical variants. These included 11 lymphomas with mixed phenotypes expressing markers of at least 2 hematopoietic lineages, 7 terminal deoxynucleotide transferase-negative lymphoblastic lymphomas, and 3 undifferentiated hematopoietic neoplasms that could not be assigned to any lineage with certainty. Our data indicate that World Health Organzation guidelines for lineage determination and subtyping of precursor cell leukemia need to be adapted before they can be applied to immunohistochemical diagnosis of lymphoma. Using the experience from this cohort we suggest a resource-saving diagnostic staining panel for the immunohistochemical analysis of precursor cell neoplasms in formalin-fixed paraffin-embedded tissue.
dcterms:title
Diagnosis and Immunophenotype of 188 Pediatric Lymphoblastic Lymphomas Treated Within a Randomized Prospective Trial: Experiences and Preliminary Recommendations From the European Childhood Lymphoma Pathology Panel Diagnosis and Immunophenotype of 188 Pediatric Lymphoblastic Lymphomas Treated Within a Randomized Prospective Trial: Experiences and Preliminary Recommendations From the European Childhood Lymphoma Pathology Panel
skos:prefLabel
Diagnosis and Immunophenotype of 188 Pediatric Lymphoblastic Lymphomas Treated Within a Randomized Prospective Trial: Experiences and Preliminary Recommendations From the European Childhood Lymphoma Pathology Panel Diagnosis and Immunophenotype of 188 Pediatric Lymphoblastic Lymphomas Treated Within a Randomized Prospective Trial: Experiences and Preliminary Recommendations From the European Childhood Lymphoma Pathology Panel
skos:notation
RIV/00064203:_____/11:6983!RIV12-MZ0-00064203
n15:predkladatel
n16:ico%3A00064203
n3:aktivita
n10:I
n3:aktivity
I
n3:cisloPeriodika
6
n3:dodaniDat
n6:2012
n3:domaciTvurceVysledku
n13:3555828
n3:druhVysledku
n12:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
194193
n3:idVysledku
RIV/00064203:_____/11:6983
n3:jazykVysledku
n5:eng
n3:klicovaSlova
MPAL; TdT; CD34; lymphoblastic; ALL; precursor; B-LBL; T-LBL; merkel cell-carcinoma; transcription factors; acute leukemias; expression; pax5; survival; pitfall; lineage; tdt
n3:klicoveSlovo
n4:MPAL n4:transcription%20factors n4:B-LBL n4:T-LBL n4:pitfall n4:CD34 n4:ALL n4:lymphoblastic n4:merkel%20cell-carcinoma n4:expression n4:pax5 n4:acute%20leukemias n4:survival n4:tdt n4:lineage n4:precursor n4:TdT
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[44E68AEBE334]
n3:nazevZdroje
American Journal of Surgical Pathology
n3:obor
n8:FJ
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
18
n3:rokUplatneniVysledku
n6:2011
n3:svazekPeriodika
35
n3:tvurceVysledku
Schmatz, AI Mc Carthy, K. Wotherspoon, A. d\'Amore, ES Abramov, D. Hebeda, K. Reiter, A. Oschlies, I. Chassagne-Clement, C. Porwit, A. Kodet, Roman Mullauer, L. Klapper, W. Maldyk, J. Zimmermann, M. Hansson, U. Burkhardt, B. Tinguely, M.
n3:wos
000290567400007
s:issn
0147-5185
s:numberOfPages
9