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Statements

Subject Item
n2:RIV%2F00064203%3A_____%2F10%3A6584%21RIV11-MZ0-00064203
rdf:type
n8:Vysledek skos:Concept
dcterms:description
The authors wanted to elucidate the possible effect of metoprolol on the gap junction protein. Cultured neonatal rat cardiomyocytes were exposed to either RS-metoprolol or R-metoprolol or S-metoprolol treatment for 24 hours without or with additional isoprenaline. The beta-blocker treatment did not alter frequency of spontaneously beating cardiomyocytes, vhereas sole isoprenaline administration significantly enhanced the beating frequency by about 40%. The authors wanted to elucidate the possible effect of metoprolol on the gap junction protein. Cultured neonatal rat cardiomyocytes were exposed to either RS-metoprolol or R-metoprolol or S-metoprolol treatment for 24 hours without or with additional isoprenaline. The beta-blocker treatment did not alter frequency of spontaneously beating cardiomyocytes, vhereas sole isoprenaline administration significantly enhanced the beating frequency by about 40%.
dcterms:title
Cardiac Gap Junction Channels Are Upregulated by Metoprolol: An Unexpected Effect of Beta-Blockers Cardiac Gap Junction Channels Are Upregulated by Metoprolol: An Unexpected Effect of Beta-Blockers
skos:prefLabel
Cardiac Gap Junction Channels Are Upregulated by Metoprolol: An Unexpected Effect of Beta-Blockers Cardiac Gap Junction Channels Are Upregulated by Metoprolol: An Unexpected Effect of Beta-Blockers
skos:notation
RIV/00064203:_____/10:6584!RIV11-MZ0-00064203
n4:aktivita
n10:V
n4:aktivity
V
n4:cisloPeriodika
4
n4:dodaniDat
n13:2011
n4:domaciTvurceVysledku
n14:2104946
n4:druhVysledku
n7:J
n4:duvernostUdaju
n12:S
n4:entitaPredkladatele
n15:predkladatel
n4:idSjednocenehoVysledku
249625
n4:idVysledku
RIV/00064203:_____/10:6584
n4:jazykVysledku
n16:eng
n4:klicovaSlova
Cx43; Cardiomyocytes; R-metoprolol; S-metoprolol; RS-metoprolol; ERK; cAMP
n4:klicoveSlovo
n5:S-metoprolol n5:ERK n5:cAMP n5:Cx43 n5:Cardiomyocytes n5:R-metoprolol n5:RS-metoprolol
n4:kodStatuVydavatele
CH - Švýcarská konfederace
n4:kontrolniKodProRIV
[E996D3059C23]
n4:nazevZdroje
Pharmacology
n4:obor
n11:FA
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
4
n4:rokUplatneniVysledku
n13:2010
n4:svazekPeriodika
85
n4:tvurceVysledku
Salemeh, Aida Dhein, Stefan Blanke, Katja Janoušek, Jan
n4:wos
000277110500002
s:issn
0031-7012
s:numberOfPages
8