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Statements

Subject Item
n2:RIV%2F00064203%3A_____%2F10%3A10209999%21RIV14-MZ0-00064203
rdf:type
n13:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1200/JCO.2009.23.2801
dcterms:description
Purpose The aim of this study was to assess the management and the obstetrical and neonatal outcomes of pregnancies complicated by cancer. Patients and Methods In an international collaborative setting, patients with invasive cancer diagnosed during pregnancy between 1998 and 2008 were identified. Clinical data regarding the cancer diagnosis and treatment and the obstetric and neonatal outcomes were collected and analyzed. Results Of 215 patients, five (2.3%) had a pregnancy that ended in a spontaneous miscarriage and 30 (14.0%) pregnancies were interrupted. Treatment was initiated during pregnancy in 122 (56.7%) patients and postpartum in 58 (27.0%) patients. The most frequently encountered cancer types were breast cancer (46%), hematologic malignancies (18%), and dermatologic malignancies (10%). The mean gestational age at delivery was 36.3 +/- 2.9 weeks. Delivery was induced in 71.7% of pregnancies, and 54.2% of children were born preterm. In the group of patients prenatally exposed to cytotoxic treatment, the prevalence of preterm labor was increased (11.8%; P=.012). Furthermore, in this group a higher proportion of small-for-gestational-age children (birth weight below 10th percentile) was observed (24.2%; P=.001). Of all neonates, 51.2% were admitted to a neonatal intensive care unit, mainly (85.2%) because of prematurity. There was no increased incidence of congenital malformations. Conclusion Pregnant cancer patients should be treated in a multidisciplinary setting with access to maternal and neonatal intensive care units. Prevention of iatrogenic prematurity appears to be an important part of the treatment strategy. Purpose The aim of this study was to assess the management and the obstetrical and neonatal outcomes of pregnancies complicated by cancer. Patients and Methods In an international collaborative setting, patients with invasive cancer diagnosed during pregnancy between 1998 and 2008 were identified. Clinical data regarding the cancer diagnosis and treatment and the obstetric and neonatal outcomes were collected and analyzed. Results Of 215 patients, five (2.3%) had a pregnancy that ended in a spontaneous miscarriage and 30 (14.0%) pregnancies were interrupted. Treatment was initiated during pregnancy in 122 (56.7%) patients and postpartum in 58 (27.0%) patients. The most frequently encountered cancer types were breast cancer (46%), hematologic malignancies (18%), and dermatologic malignancies (10%). The mean gestational age at delivery was 36.3 +/- 2.9 weeks. Delivery was induced in 71.7% of pregnancies, and 54.2% of children were born preterm. In the group of patients prenatally exposed to cytotoxic treatment, the prevalence of preterm labor was increased (11.8%; P=.012). Furthermore, in this group a higher proportion of small-for-gestational-age children (birth weight below 10th percentile) was observed (24.2%; P=.001). Of all neonates, 51.2% were admitted to a neonatal intensive care unit, mainly (85.2%) because of prematurity. There was no increased incidence of congenital malformations. Conclusion Pregnant cancer patients should be treated in a multidisciplinary setting with access to maternal and neonatal intensive care units. Prevention of iatrogenic prematurity appears to be an important part of the treatment strategy.
dcterms:title
Cancer During Pregnancy: An Analysis of 215 Patients Emphasizing the Obstetrical and the Neonatal Outcomes Cancer During Pregnancy: An Analysis of 215 Patients Emphasizing the Obstetrical and the Neonatal Outcomes
skos:prefLabel
Cancer During Pregnancy: An Analysis of 215 Patients Emphasizing the Obstetrical and the Neonatal Outcomes Cancer During Pregnancy: An Analysis of 215 Patients Emphasizing the Obstetrical and the Neonatal Outcomes
skos:notation
RIV/00064203:_____/10:10209999!RIV14-MZ0-00064203
n3:aktivita
n7:I
n3:aktivity
I
n3:cisloPeriodika
4
n3:dodaniDat
n4:2014
n3:domaciTvurceVysledku
n16:4745531
n3:druhVysledku
n17:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
249569
n3:idVysledku
RIV/00064203:_____/10:10209999
n3:jazykVysledku
n18:eng
n3:klicovaSlova
delay; membranes; malignancy; labor; stress; children; preterm birth; breast-cancer; chemotherapy in-utero
n3:klicoveSlovo
n9:malignancy n9:chemotherapy%20in-utero n9:labor n9:delay n9:stress n9:children n9:membranes n9:preterm%20birth n9:breast-cancer
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[742076C9B08C]
n3:nazevZdroje
Journal of Clinical Oncology
n3:obor
n8:FK
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
10
n3:rokUplatneniVysledku
n4:2010
n3:svazekPeriodika
28
n3:tvurceVysledku
Vergote, Ignace Van Gemert, Willemijn Van Eycken, Liesbet Gziri, Mina Mhallem Van Calsteren, Kristel Ottevanger, Nelleke Amant, Frederic Heyns, Liesbeth Halaška, Michael De Smet, Frank
n3:wos
000274138800026
s:issn
0732-183X
s:numberOfPages
7
n15:doi
10.1200/JCO.2009.23.2801