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Statements

Subject Item
n2:RIV%2F00064190%3A_____%2F13%3A%230000782%21RIV14-MZ0-00064190
rdf:type
skos:Concept n11:Vysledek
dcterms:description
Background Prospective national screening and surveillance programmes serve a range of public health functions. Objectively determining their adequacy and impact on disease may be problematic for rare disorders. We undertook to assess whether objective measures of disease surveillance intensity could be developed for the rare disorder sporadic Creutzfeldt-Jakob disease (CJD) and whether such measures correlate with disease incidence. Method From 10 countries with national human prion disease surveillance centres, the annual number of suspected prion disease cases notified to each national unit (n=17 610), referrals for cerebrospinal fluid (CSF) 14-3-3 protein diagnostic testing (n=28 780) and the number of suspect cases undergoing diagnostic neuropathological examination (n=4885) from 1993 to 2006 were collected. Age and survey year adjusted incidence rate ratios with 95% CIs were estimated using Poisson regression models to assess risk factors for sporadic, non-sporadic and all prion disease cases. Results Age and survey year adjusted analysis showed all three surveillance intensity measures (suspected human prion disease notifications, 14-3-3 protein diagnostic test referrals and neuropathological examinations of suspect cases) significantly predicted the incidence of sporadic CJD, non-sporadic CJD and all prion disease. Conclusions Routine national surveillance methods adjusted as population rates allow objective determination of surveillance intensity, which correlates positively with reported incidence for human prion disease, especially sporadic CJD, largely independent of national context. The predictive relationship between surveillance intensity and disease incidence should facilitate more rapid delineation of aberrations in disease occurrence and assessment of the adequacy of disease monitoring by national registries. Background Prospective national screening and surveillance programmes serve a range of public health functions. Objectively determining their adequacy and impact on disease may be problematic for rare disorders. We undertook to assess whether objective measures of disease surveillance intensity could be developed for the rare disorder sporadic Creutzfeldt-Jakob disease (CJD) and whether such measures correlate with disease incidence. Method From 10 countries with national human prion disease surveillance centres, the annual number of suspected prion disease cases notified to each national unit (n=17 610), referrals for cerebrospinal fluid (CSF) 14-3-3 protein diagnostic testing (n=28 780) and the number of suspect cases undergoing diagnostic neuropathological examination (n=4885) from 1993 to 2006 were collected. Age and survey year adjusted incidence rate ratios with 95% CIs were estimated using Poisson regression models to assess risk factors for sporadic, non-sporadic and all prion disease cases. Results Age and survey year adjusted analysis showed all three surveillance intensity measures (suspected human prion disease notifications, 14-3-3 protein diagnostic test referrals and neuropathological examinations of suspect cases) significantly predicted the incidence of sporadic CJD, non-sporadic CJD and all prion disease. Conclusions Routine national surveillance methods adjusted as population rates allow objective determination of surveillance intensity, which correlates positively with reported incidence for human prion disease, especially sporadic CJD, largely independent of national context. The predictive relationship between surveillance intensity and disease incidence should facilitate more rapid delineation of aberrations in disease occurrence and assessment of the adequacy of disease monitoring by national registries.
dcterms:title
Intensity of human prion disease surveillance predicts observed disease incidence Intensity of human prion disease surveillance predicts observed disease incidence
skos:prefLabel
Intensity of human prion disease surveillance predicts observed disease incidence Intensity of human prion disease surveillance predicts observed disease incidence
skos:notation
RIV/00064190:_____/13:#0000782!RIV14-MZ0-00064190
n11:predkladatel
n12:ico%3A00064190
n3:aktivita
n16:P
n3:aktivity
P(NT14145)
n3:cisloPeriodika
12
n3:dodaniDat
n5:2014
n3:domaciTvurceVysledku
n4:4091507
n3:druhVysledku
n14:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
80611
n3:idVysledku
RIV/00064190:_____/13:#0000782
n3:jazykVysledku
n17:eng
n3:klicovaSlova
CREUTZFELDT-JAKOB-DISEASE; HEPATITIS-C; CANCER; MORTALITY; INFECTION; DIAGNOSIS
n3:klicoveSlovo
n6:INFECTION n6:MORTALITY n6:DIAGNOSIS n6:CANCER n6:HEPATITIS-C n6:CREUTZFELDT-JAKOB-DISEASE
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[D33274815B72]
n3:nazevZdroje
Intensity of human prion disease surveillance predicts observed disease incidence
n3:obor
n18:FH
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
22
n3:projekt
n19:NT14145
n3:rokUplatneniVysledku
n5:2013
n3:svazekPeriodika
84
n3:tvurceVysledku
Matěj, Radoslav
n3:wos
000329916000017
s:issn
0022-3050
s:numberOfPages
5
n8:doi
10.1136/jnnp-2012-304820