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Statements

Subject Item
n2:RIV%2F00064190%3A_____%2F13%3A%230000679%21RIV14-MZ0-00064190
rdf:type
n10:Vysledek skos:Concept
dcterms:description
Background: Transjugular intrahepatic portosystemic shunts (TIPSs) have become a widely accepted tool in the treatment of patients with symptomatic portal hypertension. The aim of our study was to assess the value of cardiac markers before and after TIPS insertion for the prediction of one-year mortality in cirrhotic patients. Methods: The study population consisted of 55 patients (38 men and 17 women, aged 55.6 +/- 8.9 y, range 37-74) with liver cirrhosis treated with transjugular portosystemic shunting. Biochemical markers were measured before and 24 h after TIPS. High-sensitivity cardiac troponin T (hs-cTnT) was tested by high-sensitivity immunoassay for Elecsys analyser (Roche Diagnostics). Concentrations of creatine kinase MB isoenzyme, myoglobin (MYO), glycogenphosphorylase BB isoenzyme (GPBB) and heart type of fatty acid binding protein (FABP) were measured by the Evidence Investigator protein biochip system (Randox Laboratories). Results: In patients before TIPS insertion, hs-cTnT was increased above the cut-off (0.014 mu g/L) in 39.2% of patients. Higher hs-cTnT and FABP concentrations were associated with poor survival in patients before TIPS (hs-cTnT: P = 0.018; FABP: P = 0.016). Twenty-four hours after the TIPS procedure, we found a significant elevation in serum GPBB in comparison with preprocedural values (P < 0.001). There was an association between postprocedural concentrations of cardiac markers (MYO, hs-cTnT, FABP) and overall survival. Conclusions: Measurement of cardiac markers, mainly hs-cTnT and FABP, may be useful for mortality prediction in cirrhotic patients after TIPS. Cardiac markers are better mortality predictors than other risk factors such as age, gender or Child-Pugh score. Background: Transjugular intrahepatic portosystemic shunts (TIPSs) have become a widely accepted tool in the treatment of patients with symptomatic portal hypertension. The aim of our study was to assess the value of cardiac markers before and after TIPS insertion for the prediction of one-year mortality in cirrhotic patients. Methods: The study population consisted of 55 patients (38 men and 17 women, aged 55.6 +/- 8.9 y, range 37-74) with liver cirrhosis treated with transjugular portosystemic shunting. Biochemical markers were measured before and 24 h after TIPS. High-sensitivity cardiac troponin T (hs-cTnT) was tested by high-sensitivity immunoassay for Elecsys analyser (Roche Diagnostics). Concentrations of creatine kinase MB isoenzyme, myoglobin (MYO), glycogenphosphorylase BB isoenzyme (GPBB) and heart type of fatty acid binding protein (FABP) were measured by the Evidence Investigator protein biochip system (Randox Laboratories). Results: In patients before TIPS insertion, hs-cTnT was increased above the cut-off (0.014 mu g/L) in 39.2% of patients. Higher hs-cTnT and FABP concentrations were associated with poor survival in patients before TIPS (hs-cTnT: P = 0.018; FABP: P = 0.016). Twenty-four hours after the TIPS procedure, we found a significant elevation in serum GPBB in comparison with preprocedural values (P < 0.001). There was an association between postprocedural concentrations of cardiac markers (MYO, hs-cTnT, FABP) and overall survival. Conclusions: Measurement of cardiac markers, mainly hs-cTnT and FABP, may be useful for mortality prediction in cirrhotic patients after TIPS. Cardiac markers are better mortality predictors than other risk factors such as age, gender or Child-Pugh score.
dcterms:title
Elevated cardiac markers are associated with higher mortality in patients after transjugular intrahepatic portosystemic shunt insertion Elevated cardiac markers are associated with higher mortality in patients after transjugular intrahepatic portosystemic shunt insertion
skos:prefLabel
Elevated cardiac markers are associated with higher mortality in patients after transjugular intrahepatic portosystemic shunt insertion Elevated cardiac markers are associated with higher mortality in patients after transjugular intrahepatic portosystemic shunt insertion
skos:notation
RIV/00064190:_____/13:#0000679!RIV14-MZ0-00064190
n10:predkladatel
n11:ico%3A00064190
n3:aktivita
n6:V n6:I n6:P
n3:aktivity
I, P(NS10363), V
n3:cisloPeriodika
2
n3:dodaniDat
n9:2014
n3:domaciTvurceVysledku
n18:1447033
n3:druhVysledku
n12:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
72567
n3:idVysledku
RIV/00064190:_____/13:#0000679
n3:jazykVysledku
n14:eng
n3:klicovaSlova
Elevated cardiac marker; Transjugular intrahepatic portosystemic shunts; Biochemical marker; DISEASE; DYSFUNCTION; NATRIURETIC PEPTIDE; CIRRHOSIS
n3:klicoveSlovo
n8:CIRRHOSIS n8:DYSFUNCTION n8:DISEASE n8:NATRIURETIC%20PEPTIDE n8:Biochemical%20marker n8:Transjugular%20intrahepatic%20portosystemic%20shunts n8:Elevated%20cardiac%20marker
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[9DCAA9370510]
n3:nazevZdroje
ANNALS OF CLINICAL BIOCHEMISTRY
n3:obor
n7:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
7
n3:projekt
n15:NS10363
n3:rokUplatneniVysledku
n9:2013
n3:svazekPeriodika
50
n3:tvurceVysledku
Büchler, Tomáš
n3:wos
000319395700005
s:issn
0004-5632
s:numberOfPages
4
n19:doi
10.1258/acb.2012.012097