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Statements

Subject Item
n2:RIV%2F00064190%3A_____%2F13%3A%230000589%21RIV14-MZ0-00064190
rdf:type
n11:Vysledek skos:Concept
dcterms:description
While determinants of aortic pulse wave velocity (aPWV) are well known, much less is known about factors affecting lower-extremity pulse wave velocity (lePWV). Unlike aPWV, increased lePWV does not predict cardiovascular risk, but limits lower-extremity blood flow and is associated with increased left ventricular mass. The aim of this study was to compare the effect of cardiovascular risk factors on aPWV and lePWV. A total of 911 individuals from the Czech post-MONICA study (a randomly selected 1% representative population sample, mean age 54 +/- 13.5 years, 47% men) were examined. Pulse wave velocity was measured using the SphygmoCor device. Aging had a large effect on aPWV, but only a small effect on lePWV. After adjustment for covariates, we observed that hypertension, diabetes, chronic kidney disease and dyslipidemia were positively and significantly associated with aPWV. However, only hypertension had a significant effect on lePWV. Increased ankle systolic blood pressure was associated with increased aPWV independently of brachial blood pressure. Ankle systolic blood pressure was more closely related to aPWV than lePWV. Subjects with an ankle-brachial index <1.0 had higher aPWV and lower lePWV compared with individuals with a normal ankle-brachial index. Lower-extremity arterial stiffness is affected by age and cardiovascular risk factors to a lesser extent than aortic stiffness. Increased ankle systolic blood pressure is linked not only to increased lower-extremity arterial stiffness, but also increased aortic stiffness. In subjects with a low ankle-brachial index, lower-extremity arterial stiffness is spuriously decreased. While determinants of aortic pulse wave velocity (aPWV) are well known, much less is known about factors affecting lower-extremity pulse wave velocity (lePWV). Unlike aPWV, increased lePWV does not predict cardiovascular risk, but limits lower-extremity blood flow and is associated with increased left ventricular mass. The aim of this study was to compare the effect of cardiovascular risk factors on aPWV and lePWV. A total of 911 individuals from the Czech post-MONICA study (a randomly selected 1% representative population sample, mean age 54 +/- 13.5 years, 47% men) were examined. Pulse wave velocity was measured using the SphygmoCor device. Aging had a large effect on aPWV, but only a small effect on lePWV. After adjustment for covariates, we observed that hypertension, diabetes, chronic kidney disease and dyslipidemia were positively and significantly associated with aPWV. However, only hypertension had a significant effect on lePWV. Increased ankle systolic blood pressure was associated with increased aPWV independently of brachial blood pressure. Ankle systolic blood pressure was more closely related to aPWV than lePWV. Subjects with an ankle-brachial index <1.0 had higher aPWV and lower lePWV compared with individuals with a normal ankle-brachial index. Lower-extremity arterial stiffness is affected by age and cardiovascular risk factors to a lesser extent than aortic stiffness. Increased ankle systolic blood pressure is linked not only to increased lower-extremity arterial stiffness, but also increased aortic stiffness. In subjects with a low ankle-brachial index, lower-extremity arterial stiffness is spuriously decreased.
dcterms:title
Lower-extremity arterial stiffness vs. aortic stiffness in the general population Lower-extremity arterial stiffness vs. aortic stiffness in the general population
skos:prefLabel
Lower-extremity arterial stiffness vs. aortic stiffness in the general population Lower-extremity arterial stiffness vs. aortic stiffness in the general population
skos:notation
RIV/00064190:_____/13:#0000589!RIV14-MZ0-00064190
n11:predkladatel
n13:ico%3A00064190
n3:aktivita
n10:I n10:N n10:P
n3:aktivity
I, N, P(ED1.100/02/0123)
n3:cisloPeriodika
8
n3:dodaniDat
n18:2014
n3:domaciTvurceVysledku
n7:8395489 n7:8576068 n7:6953069
n3:druhVysledku
n14:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
85501
n3:idVysledku
RIV/00064190:_____/13:#0000589
n3:jazykVysledku
n17:eng
n3:klicovaSlova
ankle blood pressure; arterial stiffness; general population; peripheral arterial disease; pulse wave velocity
n3:klicoveSlovo
n8:ankle%20blood%20pressure n8:pulse%20wave%20velocity n8:peripheral%20arterial%20disease n8:arterial%20stiffness n8:general%20population
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[6E1E9FE2292E]
n3:nazevZdroje
HYPERTENSION RESEARCH
n3:obor
n19:FA
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
8
n3:projekt
n6:ED1.100%2F02%2F0123
n3:rokUplatneniVysledku
n18:2013
n3:svazekPeriodika
36
n3:tvurceVysledku
Cífková, Renata Wohlfahrt, Petr Krajčoviechová, Alena
n3:wos
000322714700012
s:issn
0916-9636
s:numberOfPages
6
n15:doi
10.1038/hr.2013.21