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Statements

Subject Item
n2:RIV%2F00064190%3A_____%2F12%3A%230000470%21RIV13-MZ0-00064190
rdf:type
skos:Concept n6:Vysledek
dcterms:description
OBJECTIVE: Aspirin therapy decreases mortality and ischemic complication rates after coronary artery bypass grafting (CABG). However, platelet inhibition after oral aspirin seems to be insufficient in the early postoperative period. There are incomplete data reporting aspirin efficacy early after CABG. The aim of this study was to assess the pharmacologic effect of aspirin on platelets in the first postoperative days using the most specific laboratory tests for the evaluation of aspirin efficacy. DESIGN: A prospective study. SETTING: A clinical study in one cardiac surgery center and measurements in two pharmacologic institutions. PARTICIPANTS: Thirty patients. INTERVENTIONS: Postoperative aspirin efficacy (200 mg/d) was assessed by the suppression of serum thromboxane B(2) (TxB(2)) and by arachidonic acid-induced aggregometry using the MULTIPLATE analyzer. Samples were collected before surgery and on postoperative days 1-5. METHODS AND MAIN RESULTS: The median baseline value (range) of serum TxB(2) was 1.6 ng/mL (1.4-1.9). The median TxB(2) inhibition >90% (the value required for full platelet inhibition) was not achieved until day 5 (-91%, 0.13 ng/mL [0.08-0.22], p < 0.001) and in only 55% of patients. The median baseline ASPI value was 805 (640-975) aggregation units (AU)*min. A significant decrease in aspirin insufficiency was not seen before postoperative day 5 (390 [243-621], p < 0.003) and only 34% of patients reached an effective platelet inhibition on day 5 (cutoff < 300 AU*min). CONCLUSIONS: The effect of aspirin on inhibition of TxB(2) production and arachidonic acid-induced platelet aggregation is impaired during the first postoperative days after CABG. A more effective antiplatelet strategy presumably could increase early graft patency and improve clinical outcomes after CABG. OBJECTIVE: Aspirin therapy decreases mortality and ischemic complication rates after coronary artery bypass grafting (CABG). However, platelet inhibition after oral aspirin seems to be insufficient in the early postoperative period. There are incomplete data reporting aspirin efficacy early after CABG. The aim of this study was to assess the pharmacologic effect of aspirin on platelets in the first postoperative days using the most specific laboratory tests for the evaluation of aspirin efficacy. DESIGN: A prospective study. SETTING: A clinical study in one cardiac surgery center and measurements in two pharmacologic institutions. PARTICIPANTS: Thirty patients. INTERVENTIONS: Postoperative aspirin efficacy (200 mg/d) was assessed by the suppression of serum thromboxane B(2) (TxB(2)) and by arachidonic acid-induced aggregometry using the MULTIPLATE analyzer. Samples were collected before surgery and on postoperative days 1-5. METHODS AND MAIN RESULTS: The median baseline value (range) of serum TxB(2) was 1.6 ng/mL (1.4-1.9). The median TxB(2) inhibition >90% (the value required for full platelet inhibition) was not achieved until day 5 (-91%, 0.13 ng/mL [0.08-0.22], p < 0.001) and in only 55% of patients. The median baseline ASPI value was 805 (640-975) aggregation units (AU)*min. A significant decrease in aspirin insufficiency was not seen before postoperative day 5 (390 [243-621], p < 0.003) and only 34% of patients reached an effective platelet inhibition on day 5 (cutoff < 300 AU*min). CONCLUSIONS: The effect of aspirin on inhibition of TxB(2) production and arachidonic acid-induced platelet aggregation is impaired during the first postoperative days after CABG. A more effective antiplatelet strategy presumably could increase early graft patency and improve clinical outcomes after CABG.
dcterms:title
Evaluation of aspirin's effect on platelet function early after coronary artery bypass grafting Evaluation of aspirin's effect on platelet function early after coronary artery bypass grafting
skos:prefLabel
Evaluation of aspirin's effect on platelet function early after coronary artery bypass grafting Evaluation of aspirin's effect on platelet function early after coronary artery bypass grafting
skos:notation
RIV/00064190:_____/12:#0000470!RIV13-MZ0-00064190
n6:predkladatel
n7:ico%3A00064190
n4:aktivita
n11:V n11:Z n11:I
n4:aktivity
I, V, Z(MSM0021620817)
n4:cisloPeriodika
4
n4:dodaniDat
n5:2013
n4:domaciTvurceVysledku
n9:2341271 n9:3877485
n4:druhVysledku
n18:J
n4:duvernostUdaju
n10:S
n4:entitaPredkladatele
n12:predkladatel
n4:idSjednocenehoVysledku
135061
n4:idVysledku
RIV/00064190:_____/12:#0000470
n4:jazykVysledku
n17:eng
n4:klicovaSlova
aspirin; bypass; coronary artery bypass grafting
n4:klicoveSlovo
n8:bypass n8:aspirin n8:coronary%20artery%20bypass%20grafting
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[9A1149DEED3F]
n4:nazevZdroje
Journal of cardiothoracic and vascular anesthesia
n4:obor
n19:FA
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
7
n4:rokUplatneniVysledku
n5:2012
n4:svazekPeriodika
26
n4:tvurceVysledku
Bednář, F. Paluch, Zoltán Sadílková, Lenka
n4:zamer
n15:MSM0021620817
s:issn
1053-0770
s:numberOfPages
6
n13:doi
10.1053/j.jvca.2011.12.004