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Statements

Subject Item
n2:RIV%2F00064190%3A_____%2F12%3A%230000426%21RIV13-MZ0-00064190
rdf:type
skos:Concept n12:Vysledek
dcterms:description
OBJECTIVES: It has been demonstrated that the deleterious effect of smoking on the cardiovascular system is mediated through a decrease in protective HDL cholesterol. In addition, women are more sensitive to the negative effects of smoking, although the exact mechanism underlying this phenomenon is currently unknown. In this study, we evaluated whether smoking habits could modify the association of HDL cholesterol and apolipoprotein A1 (ApoA1) with reverse cholesterol transport (RCT), as measured by cholesterol efflux (CHE), in middle-aged women. DESIGN: The study group consisted of 39 healthy middle-aged women, 21 non-smokers (age 51.8±2.5 years, BMI 25.1±2.8 kg/m2) and 18 smokers (age 50.5±3.2 years, BMI 24.8±3.5 kg/m2). In addition to all traditional cardiovascular risk factors, CHE from macrophages, labelled during a 48-hour incubation in a medium containing [14C] cholesterol, to plasma acceptors in study subjects was established as a marker of reverse cholesterol transport. RESULTS: CHE was significantly higher in non-smokers than in smokers (14.22±1.75% vs. 13.17±1.33%; p<0.05). Smoking habit had no effect on the association of HDL with ApoA1 or HDL with CHE. However, in contrast to the strong association of ApoA1 with CHE in non-smokers (r=0.62; p<0.01), no such strong association was found in smokers (r=0.38; n.s.). MAIN FINDINGS AND CONCLUSION: Based on our results, smoking can alter ApoA1-mediated reverse cholesterol transport in women. OBJECTIVES: It has been demonstrated that the deleterious effect of smoking on the cardiovascular system is mediated through a decrease in protective HDL cholesterol. In addition, women are more sensitive to the negative effects of smoking, although the exact mechanism underlying this phenomenon is currently unknown. In this study, we evaluated whether smoking habits could modify the association of HDL cholesterol and apolipoprotein A1 (ApoA1) with reverse cholesterol transport (RCT), as measured by cholesterol efflux (CHE), in middle-aged women. DESIGN: The study group consisted of 39 healthy middle-aged women, 21 non-smokers (age 51.8±2.5 years, BMI 25.1±2.8 kg/m2) and 18 smokers (age 50.5±3.2 years, BMI 24.8±3.5 kg/m2). In addition to all traditional cardiovascular risk factors, CHE from macrophages, labelled during a 48-hour incubation in a medium containing [14C] cholesterol, to plasma acceptors in study subjects was established as a marker of reverse cholesterol transport. RESULTS: CHE was significantly higher in non-smokers than in smokers (14.22±1.75% vs. 13.17±1.33%; p<0.05). Smoking habit had no effect on the association of HDL with ApoA1 or HDL with CHE. However, in contrast to the strong association of ApoA1 with CHE in non-smokers (r=0.62; p<0.01), no such strong association was found in smokers (r=0.38; n.s.). MAIN FINDINGS AND CONCLUSION: Based on our results, smoking can alter ApoA1-mediated reverse cholesterol transport in women.
dcterms:title
The Czech ABI Project - prevalence of peripheral arterial disease in patients at risk using the ankle-brachial index in general practice (a cross-sectional study). The Czech ABI Project - prevalence of peripheral arterial disease in patients at risk using the ankle-brachial index in general practice (a cross-sectional study).
skos:prefLabel
The Czech ABI Project - prevalence of peripheral arterial disease in patients at risk using the ankle-brachial index in general practice (a cross-sectional study). The Czech ABI Project - prevalence of peripheral arterial disease in patients at risk using the ankle-brachial index in general practice (a cross-sectional study).
skos:notation
RIV/00064190:_____/12:#0000426!RIV13-MZ0-00064190
n12:predkladatel
n13:ico%3A00064190
n3:aktivita
n15:N
n3:aktivity
N
n3:cisloPeriodika
2
n3:dodaniDat
n8:2013
n3:domaciTvurceVysledku
n11:8395489
n3:druhVysledku
n16:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
129391
n3:idVysledku
RIV/00064190:_____/12:#0000426
n3:jazykVysledku
n4:eng
n3:klicovaSlova
peripheral arterial disease; prevalence; ankle brachial index; cardiovascular risk factors
n3:klicoveSlovo
n9:cardiovascular%20risk%20factors n9:peripheral%20arterial%20disease n9:prevalence n9:ankle%20brachial%20index
n3:kodStatuVydavatele
SE - Švédské království
n3:kontrolniKodProRIV
[27F0503954ED]
n3:nazevZdroje
NEUROENDOCRINOLOGY LETTERS
n3:obor
n14:FA
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n8:2012
n3:svazekPeriodika
33
n3:tvurceVysledku
Karetová, D. Cífková, Renata
s:issn
0172-780X
s:numberOfPages
6