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Statements

Subject Item
n2:RIV%2F00064190%3A_____%2F11%3A%230000243%21RIV12-MZ0-00064190
rdf:type
n13:Vysledek skos:Concept
dcterms:description
Determination of mTREM-1 expression on monocytes has been investigated as a perspective diagnostic method to distinguish infectious from non-infectious etiology of the inflammation. The aims of our study were: i) to investigate the expression of TREM-1 on monocytes in septic patients and in those after elective spinal surgery without infection; ii) to assess the dynamics of mTREM-1 expression on monocytes and its association with the outcome in patients with severe sepsis. Fifty two patients with severe sepsis, 20 healthy volunteers, and 20 patients after elective spinal surgery were involved in our study. TREM-1 expression on monocytes was evaluated by flow cytometry. Compared with the group of healthy adults (median 42.0, interquartile range (IQR) 30.3–76 MFI), mTREM-1 expression was increased in the group of septic patients both at entry (median 138.4, IQR 78.4–187.5 MFI) and the last examination (median 136.5, IQR 69.0–170.0 MFI) as well as in patients 24 hours after spinal surgery (median 138.5, IQR 45.3–165.5 MFI). The increase was statistically significant. mTREM-1 expression in patients undergoing spinal surgery and those with severe sepsis did not differ. TREM-1 expression on the monocytes in survivors was higher than in non-survivors (p=0.007). TREM-1 levels in septic non-surviving patients correlated weakly with TNF-α levels (r=0.38; p=0.003) and with HLA-DR/CD14 levels (r=0.38; p=0.003). Increased TREM-1 expression on monocytes is not associated exclusively with the presence of systemic infection. Determination of mTREM-1 expression on monocytes has been investigated as a perspective diagnostic method to distinguish infectious from non-infectious etiology of the inflammation. The aims of our study were: i) to investigate the expression of TREM-1 on monocytes in septic patients and in those after elective spinal surgery without infection; ii) to assess the dynamics of mTREM-1 expression on monocytes and its association with the outcome in patients with severe sepsis. Fifty two patients with severe sepsis, 20 healthy volunteers, and 20 patients after elective spinal surgery were involved in our study. TREM-1 expression on monocytes was evaluated by flow cytometry. Compared with the group of healthy adults (median 42.0, interquartile range (IQR) 30.3–76 MFI), mTREM-1 expression was increased in the group of septic patients both at entry (median 138.4, IQR 78.4–187.5 MFI) and the last examination (median 136.5, IQR 69.0–170.0 MFI) as well as in patients 24 hours after spinal surgery (median 138.5, IQR 45.3–165.5 MFI). The increase was statistically significant. mTREM-1 expression in patients undergoing spinal surgery and those with severe sepsis did not differ. TREM-1 expression on the monocytes in survivors was higher than in non-survivors (p=0.007). TREM-1 levels in septic non-surviving patients correlated weakly with TNF-α levels (r=0.38; p=0.003) and with HLA-DR/CD14 levels (r=0.38; p=0.003). Increased TREM-1 expression on monocytes is not associated exclusively with the presence of systemic infection.
dcterms:title
TREM-1 Expression on Monocytes is not a Parameter Specific for Infectious Etiology of Systemic Inflammatory Response Syndrome TREM-1 Expression on Monocytes is not a Parameter Specific for Infectious Etiology of Systemic Inflammatory Response Syndrome
skos:prefLabel
TREM-1 Expression on Monocytes is not a Parameter Specific for Infectious Etiology of Systemic Inflammatory Response Syndrome TREM-1 Expression on Monocytes is not a Parameter Specific for Infectious Etiology of Systemic Inflammatory Response Syndrome
skos:notation
RIV/00064190:_____/11:#0000243!RIV12-MZ0-00064190
n13:predkladatel
n17:ico%3A00064190
n3:aktivita
n16:N
n3:aktivity
N
n3:cisloPeriodika
3
n3:dodaniDat
n6:2012
n3:domaciTvurceVysledku
n11:2123231 n11:2913429
n3:druhVysledku
n5:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
235983
n3:idVysledku
RIV/00064190:_____/11:#0000243
n3:jazykVysledku
n8:eng
n3:klicovaSlova
Sepsis; SIRS; REM-1; Diagnosis
n3:klicoveSlovo
n14:REM-1 n14:Sepsis n14:SIRS n14:Diagnosis
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[4833F95274D0]
n3:nazevZdroje
Prague Medical Report
n3:obor
n12:FP
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n6:2011
n3:svazekPeriodika
112
n3:tvurceVysledku
Zazula, Roman Müller, Martin Průcha, M.
s:issn
1214-6994
s:numberOfPages
11