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Statements

Subject Item
n2:RIV%2F00064173%3A_____%2F13%3A%230000338%21RIV14-MZ0-00064173
rdf:type
n5:Vysledek skos:Concept
dcterms:description
Heavy neurofilaments (NFH) released from neurons during axonal injury induce a humoral immune response. We measured CSF and serum levels of NFH proteins and anti-NFH IgG antibodies in 19 patients with clinically isolated syndrome (CIS) converting to multiple sclerosis, in 20 stable CIS patients, 23 patients with multiple sclerosis (MS) and 32 control subjects using ELISA. CSF and intrathecal levels and CSF/serum ratios of anti-NFH antibodies were increased in the CIS patients early developing MS while NFH protein concentrations were similar among the groups. Changes associated with NFH are more pronounced for antibodies than for protein itself and may aid in prediction of CIS patients. Heavy neurofilaments (NFH) released from neurons during axonal injury induce a humoral immune response. We measured CSF and serum levels of NFH proteins and anti-NFH IgG antibodies in 19 patients with clinically isolated syndrome (CIS) converting to multiple sclerosis, in 20 stable CIS patients, 23 patients with multiple sclerosis (MS) and 32 control subjects using ELISA. CSF and intrathecal levels and CSF/serum ratios of anti-NFH antibodies were increased in the CIS patients early developing MS while NFH protein concentrations were similar among the groups. Changes associated with NFH are more pronounced for antibodies than for protein itself and may aid in prediction of CIS patients.
dcterms:title
Serum and cerebrospinal fluid heavy neurofilaments and antibodies against them in early multiple sclerosis Serum and cerebrospinal fluid heavy neurofilaments and antibodies against them in early multiple sclerosis
skos:prefLabel
Serum and cerebrospinal fluid heavy neurofilaments and antibodies against them in early multiple sclerosis Serum and cerebrospinal fluid heavy neurofilaments and antibodies against them in early multiple sclerosis
skos:notation
RIV/00064173:_____/13:#0000338!RIV14-MZ0-00064173
n5:predkladatel
n14:ico%3A00064173
n3:aktivita
n10:P n10:I
n3:aktivity
I, P(NT13183)
n3:cisloPeriodika
1-2
n3:dodaniDat
n6:2014
n3:domaciTvurceVysledku
n15:1787977 n15:6721427 n15:1402455
n3:druhVysledku
n12:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
104776
n3:idVysledku
RIV/00064173:_____/13:#0000338
n3:jazykVysledku
n13:eng
n3:klicovaSlova
Serum; Multiple sclerosis; Heavy neurofllament; Clinically isolated syndrome; Cerebrospinal fluid; Antibody
n3:klicoveSlovo
n11:Heavy%20neurofllament n11:Serum n11:Cerebrospinal%20fluid n11:Antibody n11:Clinically%20isolated%20syndrome n11:Multiple%20sclerosis
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[FEB5706EF545]
n3:nazevZdroje
Journal of Neuroimmunology
n3:obor
n19:FH
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
5
n3:projekt
n16:NT13183
n3:rokUplatneniVysledku
n6:2013
n3:svazekPeriodika
259
n3:tvurceVysledku
Kotoučová, Jolana Zimová, Denisa Bartoš, Aleš
n3:wos
000319848100010
s:issn
0165-5728
s:numberOfPages
7
n17:doi
10.1016/j.jneuroim.2013.03.009