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Statements

Subject Item
n2:RIV%2F00064173%3A_____%2F12%3A43907105%21RIV13-MZ0-00064173
rdf:type
n6:Vysledek skos:Concept
dcterms:description
Myelodysplastic syndrome (MDS) with isolated 5q-chromosomal abnormality and less than 5% bone marrow blasts, according to WHO classification, represents a separate MDS subgroup. Most such patients have distinct clinical and pathological features and fit into a diagnosis of 5q-syndrome with isolated 5q-deletion, hypo-proliferative anemia, normal or increased platelet count, low bone marrow blasts (BM), dysplastic megakaryocytes and long survival. Among the most common cytogenetic abnormalities identified in patients with MDS are interstitial deletions involving the long arm of chromosome 5 in frequencies ranging from 14 to 31%. Patients with the isolated 5q-chromosomal abnormality are considered to have very good prognosis and survival often longer than 100 months. We decided to analyze the prognostic impact of thrombocytopenia in patients with isolated 5q- which is considered one of the best prognostic groups. With the spreading use of potent and expensive immuno-modulatory drugs, the proper selection of patients is called for, in particular with regard to the yet unresolved question of AML transformation. We suggest that cytopenia, especially thrombocytopenia at the time of diagnosis, is an important marker for identifying patients with unfavorable prognosis. Myelodysplastic syndrome (MDS) with isolated 5q-chromosomal abnormality and less than 5% bone marrow blasts, according to WHO classification, represents a separate MDS subgroup. Most such patients have distinct clinical and pathological features and fit into a diagnosis of 5q-syndrome with isolated 5q-deletion, hypo-proliferative anemia, normal or increased platelet count, low bone marrow blasts (BM), dysplastic megakaryocytes and long survival. Among the most common cytogenetic abnormalities identified in patients with MDS are interstitial deletions involving the long arm of chromosome 5 in frequencies ranging from 14 to 31%. Patients with the isolated 5q-chromosomal abnormality are considered to have very good prognosis and survival often longer than 100 months. We decided to analyze the prognostic impact of thrombocytopenia in patients with isolated 5q- which is considered one of the best prognostic groups. With the spreading use of potent and expensive immuno-modulatory drugs, the proper selection of patients is called for, in particular with regard to the yet unresolved question of AML transformation. We suggest that cytopenia, especially thrombocytopenia at the time of diagnosis, is an important marker for identifying patients with unfavorable prognosis.
dcterms:title
Thrombocytopenia at diagnosis as an important negative prognostic marker in isolated 5q-MDS (IPSS low and intermediate-1) Thrombocytopenia at diagnosis as an important negative prognostic marker in isolated 5q-MDS (IPSS low and intermediate-1)
skos:prefLabel
Thrombocytopenia at diagnosis as an important negative prognostic marker in isolated 5q-MDS (IPSS low and intermediate-1) Thrombocytopenia at diagnosis as an important negative prognostic marker in isolated 5q-MDS (IPSS low and intermediate-1)
skos:notation
RIV/00064173:_____/12:43907105!RIV13-MZ0-00064173
n6:predkladatel
n7:ico%3A00064173
n3:aktivita
n10:V n10:I
n3:aktivity
I, V
n3:cisloPeriodika
12
n3:dodaniDat
n13:2013
n3:domaciTvurceVysledku
n11:3083594
n3:druhVysledku
n14:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
174403
n3:idVysledku
RIV/00064173:_____/12:43907105
n3:jazykVysledku
n15:eng
n3:klicovaSlova
impact; myelodysplastic syndromes
n3:klicoveSlovo
n17:myelodysplastic%20syndromes n17:impact
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[8EAA39EA0351]
n3:nazevZdroje
Leukemia Research
n3:obor
n18:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
16
n3:rokUplatneniVysledku
n13:2012
n3:svazekPeriodika
36
n3:tvurceVysledku
Jonašová, Anna Černá, Olga
n3:wos
000310642500003
s:issn
0145-2126
s:numberOfPages
3
n16:doi
10.1016/j.leukres.2012.08.002