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Statements

Subject Item
n2:RIV%2F00064173%3A_____%2F12%3A43901004%21RIV13-MZ0-00064173
rdf:type
n8:Vysledek skos:Concept
dcterms:description
Granulocyte-macrophage colony stimulating factor (GM-CSF) is considered to be the most effective immunostimulating factor for the construction of gene-engineered anti-cancer vaccines. In some tumour cells, this type of genetic modification has resulted in the loss of the oncogenic potential. This was not the case with bcr-abl-transformed mouse 12B1 cells. A cell line, designated 12B1/GM-CSF/cl-5 producing more than 100 ng/106 cells/24 h, displayed higher pathogenicity than the parental, non-transduced cells. Although the tumours induced by the parental 12B1 cells and 12B1/GM-CSF/cl-5 cells appeared nearly at the same time and then grew at an approximately equal rate, the latter mice were in a much poorer clinical condition. In these animals the growth of the tumours was associated with gradually increasing blood levels of GM-CSF. In both groups of animals splenomegaly was observed; it was much more pronounced in the case of 12B1/GM-CSF/cl-5-inoculated animals. While in the case of animals inoculated with the parental cells the splenomegaly was probably mainly due to infiltration with tumour cells, in the animals inoculated with the GM-CSF-secreting cells splenomegaly and derangement of parenchymal organs, such as lungs, liver and kidneys, were more complex, including congestion and infiltration with hemopoietic cells, predominantly immature cells of myeloid lineage. The most conspicuous of these changes was the hyperaemia of the lungs. No such alterations were seen in animals inoculated with the parental cells. On the other hand, the contents of T regulatory cells were comparable in both groups and they increased in parallel at the end of the observation period. When GM-CSF neutralizing antibody was administered to animals inoculated with the 12B1/GM-CSF/cl-5 cells, the pathological changes observed within the organs were suppressed, this proving that the overproduced GM-CSF and not any other substance, played the key role in their induction. Granulocyte-macrophage colony stimulating factor (GM-CSF) is considered to be the most effective immunostimulating factor for the construction of gene-engineered anti-cancer vaccines. In some tumour cells, this type of genetic modification has resulted in the loss of the oncogenic potential. This was not the case with bcr-abl-transformed mouse 12B1 cells. A cell line, designated 12B1/GM-CSF/cl-5 producing more than 100 ng/106 cells/24 h, displayed higher pathogenicity than the parental, non-transduced cells. Although the tumours induced by the parental 12B1 cells and 12B1/GM-CSF/cl-5 cells appeared nearly at the same time and then grew at an approximately equal rate, the latter mice were in a much poorer clinical condition. In these animals the growth of the tumours was associated with gradually increasing blood levels of GM-CSF. In both groups of animals splenomegaly was observed; it was much more pronounced in the case of 12B1/GM-CSF/cl-5-inoculated animals. While in the case of animals inoculated with the parental cells the splenomegaly was probably mainly due to infiltration with tumour cells, in the animals inoculated with the GM-CSF-secreting cells splenomegaly and derangement of parenchymal organs, such as lungs, liver and kidneys, were more complex, including congestion and infiltration with hemopoietic cells, predominantly immature cells of myeloid lineage. The most conspicuous of these changes was the hyperaemia of the lungs. No such alterations were seen in animals inoculated with the parental cells. On the other hand, the contents of T regulatory cells were comparable in both groups and they increased in parallel at the end of the observation period. When GM-CSF neutralizing antibody was administered to animals inoculated with the 12B1/GM-CSF/cl-5 cells, the pathological changes observed within the organs were suppressed, this proving that the overproduced GM-CSF and not any other substance, played the key role in their induction.
dcterms:title
Properties of bcr-abl-transformed mouse 12B1 cells secreting interleukin-2 and granulocyte-macrophage colony stimulating factor (GM-CSF): II. Adverse effects of GM-CSF Properties of bcr-abl-transformed mouse 12B1 cells secreting interleukin-2 and granulocyte-macrophage colony stimulating factor (GM-CSF): II. Adverse effects of GM-CSF
skos:prefLabel
Properties of bcr-abl-transformed mouse 12B1 cells secreting interleukin-2 and granulocyte-macrophage colony stimulating factor (GM-CSF): II. Adverse effects of GM-CSF Properties of bcr-abl-transformed mouse 12B1 cells secreting interleukin-2 and granulocyte-macrophage colony stimulating factor (GM-CSF): II. Adverse effects of GM-CSF
skos:notation
RIV/00064173:_____/12:43901004!RIV13-MZ0-00064173
n8:predkladatel
n9:ico%3A00064173
n5:aktivita
n12:I n12:P
n5:aktivity
I, P(NS10634)
n5:cisloPeriodika
6
n5:dodaniDat
n13:2013
n5:domaciTvurceVysledku
n16:7449186
n5:druhVysledku
n11:J
n5:duvernostUdaju
n7:S
n5:entitaPredkladatele
n14:predkladatel
n5:idSjednocenehoVysledku
162874
n5:idVysledku
RIV/00064173:_____/12:43901004
n5:jazykVysledku
n18:eng
n5:klicovaSlova
organ damage; granulocyte-macrophage colony stimulating factor; gene-modified cells; bcr-abl
n5:klicoveSlovo
n6:bcr-abl n6:gene-modified%20cells n6:granulocyte-macrophage%20colony%20stimulating%20factor n6:organ%20damage
n5:kodStatuVydavatele
GR - Řecká republika
n5:kontrolniKodProRIV
[C502AE4454C4]
n5:nazevZdroje
International Journal of Oncology
n5:obor
n17:FD
n5:pocetDomacichTvurcuVysledku
1
n5:pocetTvurcuVysledku
5
n5:projekt
n19:NS10634
n5:rokUplatneniVysledku
n13:2012
n5:svazekPeriodika
40
n5:tvurceVysledku
Mandys, Václav Vonka, Vladimír
n5:wos
000303699900021
s:issn
1019-6439
s:numberOfPages
8
n10:doi
10.3892/ijo.2012.1410