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Statements

Subject Item
n2:RIV%2F00064173%3A_____%2F12%3A%230000384%21RIV14-MZ0-00064173
rdf:type
skos:Concept n7:Vysledek
dcterms:description
We confirmed co-localization of four breakpoints: 5q15, 5q33, 7q21.11 7q32.3 and FS in MDS patients. Their roles in clonal transformation are not yet fully characterized. However, tumor-suppressor genes and/or oncogenes are predicted to reside in these loci. Further microarray analyses of the affected chromosomal regions in combination with molecular-cytogenetic approaches will help to elucidate the degree of correlation with fragile sites. We confirmed co-localization of four breakpoints: 5q15, 5q33, 7q21.11 7q32.3 and FS in MDS patients. Their roles in clonal transformation are not yet fully characterized. However, tumor-suppressor genes and/or oncogenes are predicted to reside in these loci. Further microarray analyses of the affected chromosomal regions in combination with molecular-cytogenetic approaches will help to elucidate the degree of correlation with fragile sites.
dcterms:title
Recurrent chromosomal breakpoints in patients with myelodysplastic syndromes and complex karyotype versus fragile sites Recurrent chromosomal breakpoints in patients with myelodysplastic syndromes and complex karyotype versus fragile sites
skos:prefLabel
Recurrent chromosomal breakpoints in patients with myelodysplastic syndromes and complex karyotype versus fragile sites Recurrent chromosomal breakpoints in patients with myelodysplastic syndromes and complex karyotype versus fragile sites
skos:notation
RIV/00064173:_____/12:#0000384!RIV14-MZ0-00064173
n7:predkladatel
n8:ico%3A00064173
n4:aktivita
n6:P n6:V n6:Z
n4:aktivity
P(LC535), P(OC10043), V, Z(MSM0021620808), Z(MZ0UHKT2005), Z(MZ0VFN2005)
n4:cisloPeriodika
6
n4:dodaniDat
n12:2014
n4:domaciTvurceVysledku
n5:3083594
n4:druhVysledku
n11:J
n4:duvernostUdaju
n16:S
n4:entitaPredkladatele
n13:predkladatel
n4:idSjednocenehoVysledku
164441
n4:idVysledku
RIV/00064173:_____/12:#0000384
n4:jazykVysledku
n18:eng
n4:klicovaSlova
chromosomal breakpoints; myelodysplastic syndrome
n4:klicoveSlovo
n15:myelodysplastic%20syndrome n15:chromosomal%20breakpoints
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[CA52CF16E1B8]
n4:nazevZdroje
Leukemia Research
n4:obor
n10:FD
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
14
n4:projekt
n19:OC10043 n19:LC535
n4:rokUplatneniVysledku
n12:2012
n4:svazekPeriodika
36
n4:tvurceVysledku
Černá, Olga
n4:wos
000302961400003
n4:zamer
n9:MSM0021620808 n9:MZ0VFN2005 n9:MZ0UHKT2005
s:issn
0145-2126
s:numberOfPages
3
n20:doi
10.1016/j.leukres.2012.02.006