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Statements

Subject Item
n2:RIV%2F00064173%3A_____%2F11%3A%230000169%21RIV13-MZ0-00064173
rdf:type
skos:Concept n14:Vysledek
dcterms:description
The role of the TP53 gene's R72P polymorphism in non-Hodgkin lymphoma (NHL) has been analyzed in several studies but it has not been studied in Hodgkin lymphoma (HL). We have evaluated the role of R72P in 340 NHL and 298 HL patients. There was no difference in the R72P frequency between analyzed lymphoma cases and 749 controls. We found no association of R72P with the risk of NHL and HL development [OR(ArgPro/ProPro) = 0.9 (95% CI 0.7-1.2) and 1.2 (95% CI 0.9-1.5), respectively] or with survival. Our results support the evidence that R72P is not a prognostic factor in Caucasian NHL patients, and they indicate its irrelevance for HL development or prognosis. The role of the TP53 gene's R72P polymorphism in non-Hodgkin lymphoma (NHL) has been analyzed in several studies but it has not been studied in Hodgkin lymphoma (HL). We have evaluated the role of R72P in 340 NHL and 298 HL patients. There was no difference in the R72P frequency between analyzed lymphoma cases and 749 controls. We found no association of R72P with the risk of NHL and HL development [OR(ArgPro/ProPro) = 0.9 (95% CI 0.7-1.2) and 1.2 (95% CI 0.9-1.5), respectively] or with survival. Our results support the evidence that R72P is not a prognostic factor in Caucasian NHL patients, and they indicate its irrelevance for HL development or prognosis.
dcterms:title
No association between the TP53 codon 72 polymorphism and risk or prognosis of Hodgkin and non-Hodgkin lymphoma No association between the TP53 codon 72 polymorphism and risk or prognosis of Hodgkin and non-Hodgkin lymphoma
skos:prefLabel
No association between the TP53 codon 72 polymorphism and risk or prognosis of Hodgkin and non-Hodgkin lymphoma No association between the TP53 codon 72 polymorphism and risk or prognosis of Hodgkin and non-Hodgkin lymphoma
skos:notation
RIV/00064173:_____/11:#0000169!RIV13-MZ0-00064173
n14:predkladatel
n15:ico%3A00064173
n3:aktivita
n9:I n9:S n9:Z
n3:aktivity
I, S, Z(MSM0021620808), Z(MSM0021620813)
n3:cisloPeriodika
8
n3:dodaniDat
n12:2013
n3:domaciTvurceVysledku
n6:8199108 n6:3092364
n3:druhVysledku
n5:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
216109
n3:idVysledku
RIV/00064173:_____/11:#0000169
n3:jazykVysledku
n13:eng
n3:klicovaSlova
TP53 gene (p53),; Arg72Pro polymorphism (R72P); Non-Hodgkin lymphoma; Hodgkin lymphoma; Genetic predispositio
n3:klicoveSlovo
n8:TP53%20gene%20%28p53%29 n8:Hodgkin%20lymphoma n8:Genetic%20predispositio n8:Arg72Pro%20polymorphism%20%28R72P%29 n8:Non-Hodgkin%20lymphoma
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[D2874524B0DB]
n3:nazevZdroje
Leukemia Research
n3:obor
n10:FD
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
8
n3:rokUplatneniVysledku
n12:2011
n3:svazekPeriodika
35
n3:tvurceVysledku
Havránek, Ondřej Móciková, Heidi Špaček, Martin
n3:wos
000292735300026
n3:zamer
n16:MSM0021620808 n16:MSM0021620813
s:issn
0145-2126
s:numberOfPages
3
n11:doi
10.1016/j.leukres.2011.04.001