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Statements

Subject Item
n2:RIV%2F00064173%3A_____%2F11%3A%230000091%21RIV12-MZ0-00064173
rdf:type
skos:Concept n7:Vysledek
dcterms:description
Prior studies demonstrate a direct relationship between treatment delays to primary percutaneous intervention and mortality in patients with ST-segment elevation myocardial infarction (STEMI). This analysis compared the relationship of symptom onset-to-balloon time and door-to-balloon time on mortality in patients with STEMI. We analyzed different treatment delays (symptom onset-to-balloon time, door-to-balloon time) and mortality in 5745 STEMI patients. Baseline characteristics, flow grade, 90-day mortality, and clinical outcomes were compared in patients stratified by treatment delay. Multivariable logistic regression modeling was performed to assess the independent and relative effect of each treatment delay on 90-day mortality. Female sex, increased age, and worse thrombolysis in myocardial infarction flow grade were significantly associated with longer symptom onset-to-balloon times and door-to-balloon times. Longer symptom onset-to-balloon time was significantly associated with worse 90-day mortality (3.7%, 4.2%, and 6.5% for time delays 3 hours, 3 to 5 hours, and > 5 hours, respectively, P < 0.0001). Similarly, longer door-to-balloon times were significantly associated with worse 90-day mortality (3.2%, 4.0%, 4.6%, and 5.3% for delays < 60 minutes, 60 to 90 minutes, 90 to 120 minutes, and >= 120 minutes respectively, P < 0.0001). In a multivariate model of 90-day mortality, door-to-balloon time (chi(2) 6.0, P < 0.014), and symptom onset-to-hospital arrival (chi(2) 9.8, P < 0.007) remained independent determinants. Both symptom onset-to-balloon time and hospital door-to-balloon time are strongly associated with 90-day mortality following STEMI. Prior studies demonstrate a direct relationship between treatment delays to primary percutaneous intervention and mortality in patients with ST-segment elevation myocardial infarction (STEMI). This analysis compared the relationship of symptom onset-to-balloon time and door-to-balloon time on mortality in patients with STEMI. We analyzed different treatment delays (symptom onset-to-balloon time, door-to-balloon time) and mortality in 5745 STEMI patients. Baseline characteristics, flow grade, 90-day mortality, and clinical outcomes were compared in patients stratified by treatment delay. Multivariable logistic regression modeling was performed to assess the independent and relative effect of each treatment delay on 90-day mortality. Female sex, increased age, and worse thrombolysis in myocardial infarction flow grade were significantly associated with longer symptom onset-to-balloon times and door-to-balloon times. Longer symptom onset-to-balloon time was significantly associated with worse 90-day mortality (3.7%, 4.2%, and 6.5% for time delays 3 hours, 3 to 5 hours, and > 5 hours, respectively, P < 0.0001). Similarly, longer door-to-balloon times were significantly associated with worse 90-day mortality (3.2%, 4.0%, 4.6%, and 5.3% for delays < 60 minutes, 60 to 90 minutes, 90 to 120 minutes, and >= 120 minutes respectively, P < 0.0001). In a multivariate model of 90-day mortality, door-to-balloon time (chi(2) 6.0, P < 0.014), and symptom onset-to-hospital arrival (chi(2) 9.8, P < 0.007) remained independent determinants. Both symptom onset-to-balloon time and hospital door-to-balloon time are strongly associated with 90-day mortality following STEMI. Prior studies demonstrate a direct relationship between treatment delays to primary percutaneous intervention and mortality in patients with ST-segment elevation myocardial infarction (STEMI). This analysis compared the relationship of symptom onset-to-balloon time and door-to-balloon time on mortality in patients with STEMI. We analyzed different treatment delays (symptom onset-to-balloon time, door-to-balloon time) and mortality in 5745 STEMI patients. Baseline characteristics, flow grade, 90-day mortality, and clinical outcomes were compared in patients stratified by treatment delay. Multivariable logistic regression modeling was performed to assess the independent and relative effect of each treatment delay on 90-day mortality. Female sex, increased age, and worse thrombolysis in myocardial infarction flow grade were significantly associated with longer symptom onset-to-balloon times and door-to-balloon times. Longer symptom onset-to-balloon time was significantly associated with worse 90-day mortality (3.7%, 4.2%, and 6.5% for time delays 3 hours, 3 to 5 hours, and > 5 hours, respectively, P < 0.0001). Similarly, longer door-to-balloon times were significantly associated with worse 90-day mortality (3.2%, 4.0%, 4.6%, and 5.3% for delays < 60 minutes, 60 to 90 minutes, 90 to 120 minutes, and >= 120 minutes respectively, P < 0.0001). In a multivariate model of 90-day mortality, door-to-balloon time (chi(2) 6.0, P < 0.014), and symptom onset-to-hospital arrival (chi(2) 9.8, P < 0.007) remained independent determinants. Both symptom onset-to-balloon time and hospital door-to-balloon time are strongly associated with 90-day mortality following STEMI.
dcterms:title
Mortality Implications of Primary Percutaneous Coronary Intervention Treatment Delays: Insights From the Assessment of Pexelizumab in Acute Myocardial Infarction Trial Mortality Implications of Primary Percutaneous Coronary Intervention Treatment Delays: Insights From the Assessment of Pexelizumab in Acute Myocardial Infarction Trial Mortality Implications of Primary Percutaneous Coronary Intervention Treatment Delays: Insights From the Assessment of Pexelizumab in Acute Myocardial Infarction Trial
skos:prefLabel
Mortality Implications of Primary Percutaneous Coronary Intervention Treatment Delays: Insights From the Assessment of Pexelizumab in Acute Myocardial Infarction Trial Mortality Implications of Primary Percutaneous Coronary Intervention Treatment Delays: Insights From the Assessment of Pexelizumab in Acute Myocardial Infarction Trial Mortality Implications of Primary Percutaneous Coronary Intervention Treatment Delays: Insights From the Assessment of Pexelizumab in Acute Myocardial Infarction Trial
skos:notation
RIV/00064173:_____/11:#0000091!RIV12-MZ0-00064173
n7:predkladatel
n8:ico%3A00064173
n3:aktivita
n10:N
n3:aktivity
N
n3:cisloPeriodika
2
n3:dodaniDat
n13:2012
n3:domaciTvurceVysledku
n11:2228734
n3:druhVysledku
n5:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
213782
n3:idVysledku
RIV/00064173:_____/11:#0000091
n3:jazykVysledku
n16:cze
n3:klicovaSlova
myocardial infarction, angioplasty, reperfusion, mortality
n3:klicoveSlovo
n4:reperfusion n4:angioplasty n4:mortality n4:myocardial%20infarction
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[51617F8C4C59]
n3:nazevZdroje
Circulation - Cardiovascular Quality and Outcomes
n3:obor
n17:FA
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
11
n3:rokUplatneniVysledku
n13:2011
n3:svazekPeriodika
4
n3:tvurceVysledku
Ruzyllo, W. Weaver, WD Holmes, D. Aylward, PE O'Neil, WW Granger, CB Mahaffey, KW Widimský, P. Armstrong, PW Stebbins, A. L. Hudson, MP
s:issn
1941-7713
s:numberOfPages
10