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Statements

Subject Item
n2:RIV%2F00064173%3A_____%2F10%3A00002546%21RIV13-MZ0-00064173
rdf:type
n5:Vysledek skos:Concept
dcterms:description
P>Infantile spasms are the classical seizure type of West syndrome. Infantile spasms often herald a dismal prognosis, due to the high probability to evolve into intractable forms of epilepsies with significant cognitive deficits, especially if not adequately treated. The current therapies-high doses of adrenocorticotropic hormone, steroids, or the gamma-aminobutyric acid (GABA) transaminase inhibitor vigabatrin-are often toxic and may not always be effective. The need to identify new therapies for spasms has led to the generation of a number of rodent models of infantile spasms. These include acute and chronic models of infantile spasms, with cryptogenic or symptomatic origin, many of which are based on specific etiologies. In this review, we summarize the clinical experience with treating infantile spasms and the main features of the new animal models of infantile spasms and discuss their utility in the preclinical development of new therapies for infantile spasms. P>Infantile spasms are the classical seizure type of West syndrome. Infantile spasms often herald a dismal prognosis, due to the high probability to evolve into intractable forms of epilepsies with significant cognitive deficits, especially if not adequately treated. The current therapies-high doses of adrenocorticotropic hormone, steroids, or the gamma-aminobutyric acid (GABA) transaminase inhibitor vigabatrin-are often toxic and may not always be effective. The need to identify new therapies for spasms has led to the generation of a number of rodent models of infantile spasms. These include acute and chronic models of infantile spasms, with cryptogenic or symptomatic origin, many of which are based on specific etiologies. In this review, we summarize the clinical experience with treating infantile spasms and the main features of the new animal models of infantile spasms and discuss their utility in the preclinical development of new therapies for infantile spasms.
dcterms:title
Modeling new therapies for infantile spasms Modeling new therapies for infantile spasms
skos:prefLabel
Modeling new therapies for infantile spasms Modeling new therapies for infantile spasms
skos:notation
RIV/00064173:_____/10:00002546!RIV13-MZ0-00064173
n3:aktivita
n14:S n14:N
n3:aktivity
N, S
n3:cisloPeriodika
Suppl. 3
n3:dodaniDat
n12:2013
n3:domaciTvurceVysledku
n15:2633892
n3:druhVysledku
n13:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
271854
n3:idVysledku
RIV/00064173:_____/10:00002546
n3:jazykVysledku
n17:eng
n3:klicovaSlova
Rapamycin; mTOR; Vigabatrin; Adrenocorticotropic hormone; Models; Infantile spasms
n3:klicoveSlovo
n9:Adrenocorticotropic%20hormone n9:Vigabatrin n9:Rapamycin n9:Models n9:mTOR n9:Infantile%20spasms
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[175800B37483]
n3:nazevZdroje
Epilepsia
n3:obor
n10:FH
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n12:2010
n3:svazekPeriodika
51
n3:tvurceVysledku
Chudomelová, Lenka
n3:wos
000279442400005
s:issn
0013-9580
s:numberOfPages
7
n7:doi
10.1111/j.1528-1167.2010.02605.x