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Statements

Subject Item
n2:RIV%2F00064173%3A_____%2F10%3A00002542%21RIV13-MZ0-00064173
rdf:type
n11:Vysledek skos:Concept
dcterms:description
We have been focused on patients with preoperative irradiation and compared two modes of radiotherapy, short-term (15 days) and long-term (45 days). Methodology: Monitored group of 183 patients who had undergone a preoperative irradiation between 01/01/1998 and 12/31/2002 were irradiated in two modes: with a dose of 45Gy applied in 25 fractions/1.8Gy per fraction (CFD45) and a dose of 34.5Gy in 15 fractions/2.3Gy per fraction (CFD34.5). Results: No statistically significant difference in the occurrence of acute and postoperative complications, of locoregional recurrences and secondary dissemination, was mentioned in either group. In patients irradiated with CFD34.5 amputation of the rectum followed in 55%, and unlike the group irradiated with CFD45 the percentage of amputations was significantly lower (42%). We have recorded the average 5-year overall survival (OS) in those irradiated with CFD34.5 in 54% versus 61% in those irradiated with CFD45. More considerable conclusion was made comparing a 5-year disease-specific survival (DSS) versus the mode of irradiation, CFD34.5 57%, versus CFD45 71%. The significance level reached 10% (p=0.057). Conclusions: Pre-operative irradiation of the rectal cancer with the dose of 45Gy in 25 fractions/dose of 1.8Gy per fraction is a standard recommended procedure We have been focused on patients with preoperative irradiation and compared two modes of radiotherapy, short-term (15 days) and long-term (45 days). Methodology: Monitored group of 183 patients who had undergone a preoperative irradiation between 01/01/1998 and 12/31/2002 were irradiated in two modes: with a dose of 45Gy applied in 25 fractions/1.8Gy per fraction (CFD45) and a dose of 34.5Gy in 15 fractions/2.3Gy per fraction (CFD34.5). Results: No statistically significant difference in the occurrence of acute and postoperative complications, of locoregional recurrences and secondary dissemination, was mentioned in either group. In patients irradiated with CFD34.5 amputation of the rectum followed in 55%, and unlike the group irradiated with CFD45 the percentage of amputations was significantly lower (42%). We have recorded the average 5-year overall survival (OS) in those irradiated with CFD34.5 in 54% versus 61% in those irradiated with CFD45. More considerable conclusion was made comparing a 5-year disease-specific survival (DSS) versus the mode of irradiation, CFD34.5 57%, versus CFD45 71%. The significance level reached 10% (p=0.057). Conclusions: Pre-operative irradiation of the rectal cancer with the dose of 45Gy in 25 fractions/dose of 1.8Gy per fraction is a standard recommended procedure
dcterms:title
Preoperative radiotherapy of rectal cancer-influence of fractionation and dose Preoperative radiotherapy of rectal cancer-influence of fractionation and dose
skos:prefLabel
Preoperative radiotherapy of rectal cancer-influence of fractionation and dose Preoperative radiotherapy of rectal cancer-influence of fractionation and dose
skos:notation
RIV/00064173:_____/10:00002542!RIV13-MZ0-00064173
n4:aktivita
n14:V
n4:aktivity
V
n4:cisloPeriodika
98
n4:dodaniDat
n6:2013
n4:domaciTvurceVysledku
n13:9920781 n13:4317882 n13:8978182
n4:druhVysledku
n9:J
n4:duvernostUdaju
n15:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
281329
n4:idVysledku
RIV/00064173:_____/10:00002542
n4:jazykVysledku
n10:eng
n4:klicovaSlova
preoperative radiotherapy; rectal cancer
n4:klicoveSlovo
n8:preoperative%20radiotherapy n8:rectal%20cancer
n4:kodStatuVydavatele
DE - Spolková republika Německo
n4:kontrolniKodProRIV
[D0400CE6F1F0]
n4:nazevZdroje
Hepato-Gastroenterology
n4:obor
n5:FD
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
4
n4:rokUplatneniVysledku
n6:2010
n4:svazekPeriodika
57
n4:tvurceVysledku
Ambruš, Miloslav Šejdová, Markéta Kubecová, Martina
n4:wos
000278938200013
s:issn
0172-6390
s:numberOfPages
5