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Statements

Subject Item
n2:RIV%2F00064173%3A_____%2F10%3A00002431%21RIV13-MZ0-00064173
rdf:type
skos:Concept n18:Vysledek
dcterms:description
The p160 steroid receptor coactivator (SRC) family is critical to the transcriptional activation function of nuclear hormone receptors. A key member of this family is SRC-3, initially found to be amplified and expressed in breast cancer it has subsequent been shown to be expressed in malignant disease arising from a wide range of other organs. An understanding of the potential role of SRC-3 in the pathogenesis and its possible prognostic role in a broad range of tumours will improve our general understanding of carcinogenesis as well as potentially leading to a new prognostic marker as well as new therapeutic targets. SRC-3 appears to be implicated in the possible risk of developing prostate and ovarian cancer. Its presence appears to be a marker of aggressive disease. Further research is required to determine its predictive and prognostic utility given the relative paucity of studies for each specific malignant disease. The p160 steroid receptor coactivator (SRC) family is critical to the transcriptional activation function of nuclear hormone receptors. A key member of this family is SRC-3, initially found to be amplified and expressed in breast cancer it has subsequent been shown to be expressed in malignant disease arising from a wide range of other organs. An understanding of the potential role of SRC-3 in the pathogenesis and its possible prognostic role in a broad range of tumours will improve our general understanding of carcinogenesis as well as potentially leading to a new prognostic marker as well as new therapeutic targets. SRC-3 appears to be implicated in the possible risk of developing prostate and ovarian cancer. Its presence appears to be a marker of aggressive disease. Further research is required to determine its predictive and prognostic utility given the relative paucity of studies for each specific malignant disease.
dcterms:title
The role of steroid receptor coactivator-3 (SRC-3) in human malignant disease The role of steroid receptor coactivator-3 (SRC-3) in human malignant disease
skos:prefLabel
The role of steroid receptor coactivator-3 (SRC-3) in human malignant disease The role of steroid receptor coactivator-3 (SRC-3) in human malignant disease
skos:notation
RIV/00064173:_____/10:00002431!RIV13-MZ0-00064173
n3:aktivita
n12:P n12:I
n3:aktivity
I, P(NS9975)
n3:cisloPeriodika
3
n3:dodaniDat
n16:2013
n3:domaciTvurceVysledku
n13:7916396 n13:1293354
n3:druhVysledku
n9:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
285752
n3:idVysledku
RIV/00064173:_____/10:00002431
n3:jazykVysledku
n14:eng
n3:klicovaSlova
tumor marker; steroid receptor coactivator 3
n3:klicoveSlovo
n15:steroid%20receptor%20coactivator%203 n15:tumor%20marker
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[D2689C38E1FC]
n3:nazevZdroje
EJSO - European Journal of Surgical Oncology
n3:obor
n6:FD
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
6
n3:projekt
n11:NS9975
n3:rokUplatneniVysledku
n16:2010
n3:svazekPeriodika
36
n3:tvurceVysledku
Líbalová, Pavla Gojiš, Ondřej
n3:wos
000276678000002
s:issn
0748-7983
s:numberOfPages
6
n17:doi
10.1016/j.ejso.2009.08.002