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Statements

Subject Item
n2:RIV%2F00064173%3A_____%2F10%3A%230000049%21RIV11-MZ0-00064173
rdf:type
skos:Concept n17:Vysledek
dcterms:description
It is well know that oligomeric/aggregated amyloid B peptides are a key player in the pathogenesis of Alzheimer´sdisease and that different nanoparticles influance oligomerization/aggregation processes in experiments in vitro. Our previous results demonstrated antiaggregation effects of magnetite nanoparticles in the case ofprotein lysozyme, however, they have yet to be supported by biological samples containing peptides/proteins preaggregatedin vivo. In the study, Thioflavin T based fluorescence was evaluated on cerebrospinal fluid samples from people with Alzheimer´s disease/multiple sclerosis and corresponding age-related controls using magnetite nanoparticles incubated for 24h. OUR results are as follow: (i) fluorescence of semples without nanopparticles was significantly highter in both older groups. ( old controls and people with Alzheimer´s diseases) than in those of younger (young controls and people with multiplesclerosis). It is well know that oligomeric/aggregated amyloid B peptides are a key player in the pathogenesis of Alzheimer´sdisease and that different nanoparticles influance oligomerization/aggregation processes in experiments in vitro. Our previous results demonstrated antiaggregation effects of magnetite nanoparticles in the case ofprotein lysozyme, however, they have yet to be supported by biological samples containing peptides/proteins preaggregatedin vivo. In the study, Thioflavin T based fluorescence was evaluated on cerebrospinal fluid samples from people with Alzheimer´s disease/multiple sclerosis and corresponding age-related controls using magnetite nanoparticles incubated for 24h. OUR results are as follow: (i) fluorescence of semples without nanopparticles was significantly highter in both older groups. ( old controls and people with Alzheimer´s diseases) than in those of younger (young controls and people with multiplesclerosis).
dcterms:title
Attenuated antiaggregation effects of magnetite nanoparticles in cerebrosinal fluid of people with Alzheimer´s disease. Attenuated antiaggregation effects of magnetite nanoparticles in cerebrosinal fluid of people with Alzheimer´s disease.
skos:prefLabel
Attenuated antiaggregation effects of magnetite nanoparticles in cerebrosinal fluid of people with Alzheimer´s disease. Attenuated antiaggregation effects of magnetite nanoparticles in cerebrosinal fluid of people with Alzheimer´s disease.
skos:notation
RIV/00064173:_____/10:#0000049!RIV11-MZ0-00064173
n3:aktivita
n10:I n10:P
n3:aktivity
I, P(NS10369)
n3:cisloPeriodika
11
n3:dodaniDat
n9:2011
n3:domaciTvurceVysledku
n7:2322986 n7:1787977
n3:druhVysledku
n14:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
248070
n3:idVysledku
RIV/00064173:_____/10:#0000049
n3:jazykVysledku
n8:eng
n3:klicovaSlova
magnetite nanoparticles, cerebrospinal fluid, Alzheimer disease
n3:klicoveSlovo
n12:Alzheimer%20disease n12:cerebrospinal%20fluid n12:magnetite%20nanoparticles
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[A5BDB0216577]
n3:nazevZdroje
Molecular Biosystems
n3:obor
n15:FH
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
8
n3:projekt
n11:NS10369
n3:rokUplatneniVysledku
n9:2010
n3:svazekPeriodika
6
n3:tvurceVysledku
Čechová, Linda Krištofíková, Z. Klaschka, J. Antošová, A. Gažová, Z. Řípová, D. Říčný, J. Bartoš, Aleš
s:issn
1742-206X
s:numberOfPages
6