This HTML5 document contains 48 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n16http://linked.opendata.cz/resource/domain/vavai/projekt/
n10http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n7http://linked.opendata.cz/ontology/domain/vavai/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n15http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00064173%3A_____%2F08%3A00001288%21RIV13-MZ0-00064173/
n6http://bibframe.org/vocab/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n4http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n12http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n18http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n11http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n14http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n8http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00064173%3A_____%2F08%3A00001288%21RIV13-MZ0-00064173
rdf:type
n7:Vysledek skos:Concept
dcterms:description
p53 is implemented in many processes controlling cell fate. Recently it has been reported that besides post-translational modifications and regulation of protein-protein interactions, the activity of p53 is also substantially controlled at transcriptional level. In 109 out of 127 (86%) patients with chronic lymphocytic leukemia (CLL) we have identified a novel p53 splicing variant, lacking the whole coding sequence of exon 6. This splicing p53 isoform (%22delta ex6%22) is devoid of transactivational activity and is differentially expressed in CLL patients as compared to healthy controls. The overexpression of %22delta ex6%22 p53 variant in CLL patients supports the recent evidence on dysregulation of p53 splicing pattern in malignancies p53 is implemented in many processes controlling cell fate. Recently it has been reported that besides post-translational modifications and regulation of protein-protein interactions, the activity of p53 is also substantially controlled at transcriptional level. In 109 out of 127 (86%) patients with chronic lymphocytic leukemia (CLL) we have identified a novel p53 splicing variant, lacking the whole coding sequence of exon 6. This splicing p53 isoform (%22delta ex6%22) is devoid of transactivational activity and is differentially expressed in CLL patients as compared to healthy controls. The overexpression of %22delta ex6%22 p53 variant in CLL patients supports the recent evidence on dysregulation of p53 splicing pattern in malignancies
dcterms:title
Identification of a novel, trans activation-defective splicing variant of p53 gene in patients with chronic lymphocytic leukemia Identification of a novel, trans activation-defective splicing variant of p53 gene in patients with chronic lymphocytic leukemia
skos:prefLabel
Identification of a novel, trans activation-defective splicing variant of p53 gene in patients with chronic lymphocytic leukemia Identification of a novel, trans activation-defective splicing variant of p53 gene in patients with chronic lymphocytic leukemia
skos:notation
RIV/00064173:_____/08:00001288!RIV13-MZ0-00064173
n3:aktivita
n11:V n11:P
n3:aktivity
P(NR9186), V
n3:cisloPeriodika
3
n3:dodaniDat
n8:2013
n3:domaciTvurceVysledku
n10:3092364 n10:1463268
n3:druhVysledku
n14:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
371198
n3:idVysledku
RIV/00064173:_____/08:00001288
n3:jazykVysledku
n18:eng
n3:klicovaSlova
yeast; protein; modifier; radiation; expression; phosphatase; mdm2; mutation; isoforms; functional assay
n3:klicoveSlovo
n4:isoforms n4:modifier n4:phosphatase n4:yeast n4:functional%20assay n4:expression n4:protein n4:mdm2 n4:mutation n4:radiation
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[30DF25609CA6]
n3:nazevZdroje
Leukemia Research
n3:obor
n17:FD
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
6
n3:projekt
n16:NR9186
n3:rokUplatneniVysledku
n8:2008
n3:svazekPeriodika
32
n3:tvurceVysledku
Špaček, Martin Kozák, Tomáš
n3:wos
000254597400005
s:issn
0145-2126
s:numberOfPages
6
n6:doi
10.1016/j.leukres.2007.06.022