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Statements

Subject Item
n2:RIV%2F00064173%3A_____%2F08%3A%230000016%21RIV13-MZ0-00064173
rdf:type
skos:Concept n14:Vysledek
dcterms:description
The purpose of the study is to determine incidence and prognostic impact of osseous Hodgkin lymphoma (HL). Between 1997 and 2004, 198 patients with HL were treated at our institution. Advanced stages and nodular sclerosis histology prevailed. All patients were treated according to protocols of the German Hodgkin Study Group (GHSG). After minimum follow-up of 24 months, we retrospectively analyzed the incidence of osseous HL, treatment response and parameters of survival. We recorded 14 cases of osseous HL (7 %), always with concurrent nodal disease. Axial skeleton was most frequently involved. Eleven patients (78,5 %) achieved complete remission and three (21,5 %) progressed primarily. The patients with osseous HL had significantly lower 2-year freedom from treatment failure than the patients without bone involvement (71,4 and 92,7 %, respectively, p=0,004), with no significant difference in 2-year overall survival (85,7 and 95 %, respectively, p=0,14). On multivariate analysis, advanced stage was the only independent adverse prognostic factor. In conclusion, bone involvement is a relatively common finding in HL and is not an independent adverse prognostic factor. The purpose of the study is to determine incidence and prognostic impact of osseous Hodgkin lymphoma (HL). Between 1997 and 2004, 198 patients with HL were treated at our institution. Advanced stages and nodular sclerosis histology prevailed. All patients were treated according to protocols of the German Hodgkin Study Group (GHSG). After minimum follow-up of 24 months, we retrospectively analyzed the incidence of osseous HL, treatment response and parameters of survival. We recorded 14 cases of osseous HL (7 %), always with concurrent nodal disease. Axial skeleton was most frequently involved. Eleven patients (78,5 %) achieved complete remission and three (21,5 %) progressed primarily. The patients with osseous HL had significantly lower 2-year freedom from treatment failure than the patients without bone involvement (71,4 and 92,7 %, respectively, p=0,004), with no significant difference in 2-year overall survival (85,7 and 95 %, respectively, p=0,14). On multivariate analysis, advanced stage was the only independent adverse prognostic factor. In conclusion, bone involvement is a relatively common finding in HL and is not an independent adverse prognostic factor.
dcterms:title
Prognostic impact of bone involvement in Hodgkin lymphoma Prognostic impact of bone involvement in Hodgkin lymphoma
skos:prefLabel
Prognostic impact of bone involvement in Hodgkin lymphoma Prognostic impact of bone involvement in Hodgkin lymphoma
skos:notation
RIV/00064173:_____/08:#0000016!RIV13-MZ0-00064173
n3:aktivita
n5:P n5:V n5:Z
n3:aktivity
P(NR8033), V, Z(MSM0021620808)
n3:cisloPeriodika
2
n3:dodaniDat
n10:2013
n3:domaciTvurceVysledku
n4:1463268 n4:4504992
n3:druhVysledku
n17:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
390186
n3:idVysledku
RIV/00064173:_____/08:#0000016
n3:jazykVysledku
n16:eng
n3:klicovaSlova
Hodgkin lymphoma
n3:klicoveSlovo
n13:Hodgkin%20lymphoma
n3:kodStatuVydavatele
SK - Slovenská republika
n3:kontrolniKodProRIV
[A89C4F63674C]
n3:nazevZdroje
Neoplasma
n3:obor
n6:FD
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
5
n3:projekt
n18:NR8033
n3:rokUplatneniVysledku
n10:2008
n3:svazekPeriodika
55
n3:tvurceVysledku
Marková, Jana Kozák, Tomáš
n3:wos
000253229100003
n3:zamer
n12:MSM0021620808
s:issn
0028-2685
s:numberOfPages
5