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Statements

Subject Item
n2:RIV%2F00064165%3A_____%2F13%3A10193014%21RIV14-MZ0-00064165
rdf:type
skos:Concept n12:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1136/jnnp-2012-304740
dcterms:description
Objectives: To investigate the associations of serum lipid profile with disease progression in high-risk clinically isolated syndromes (CIS) after the first demyelinating event. Methods: High density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were obtained in pretreatment serum from 135 high risk patients with CIS (GREATER-THAN OR EQUAL TO2 brain MRI lesions and GREATER-THAN OR EQUAL TO2 oligoclonal bands) enrolled in the Observational Study of Early Interferon β-1a Treatment in High Risk Subjects after CIS study (SET study), which prospectively evaluated the effect of intramuscular interferon β-1a treatment following the first demyelinating event. Thyroid stimulating hormone, free thyroxine, 25-hydroxy vitamin D3, active smoking status and body mass index were also obtained. Clinical and MRI assessments were obtained within 4 months of the initial demyelinating event and at 6, 12 and 24 months. Results: The time to first relapse and number of relapses were not associated with any of the lipid profile variables. Higher LDL-C (p=0.006) and TC (p=0.001) levels were associated with increased cumulative number of new T2 lesions over 2 years. Higher free thyroxine levels were associated with lower cumulative number of contrast-enhancing lesions (p=0.008). Higher TC was associated as a trend with lower baseline whole brain volume (p=0.020). Higher high density lipoprotein was associated with higher deseasonalised 1,25-dihydroxy vitamin D3 (p=0.003) levels and a trend was found for deseasonalised 25-hydroxy vitamin D3 (p=0.014). Conclusions: In early multiple sclerosis, lipid profile variables particularly LDL-C and TC levels are associated with inflammatory MRI activity measures. Objectives: To investigate the associations of serum lipid profile with disease progression in high-risk clinically isolated syndromes (CIS) after the first demyelinating event. Methods: High density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were obtained in pretreatment serum from 135 high risk patients with CIS (GREATER-THAN OR EQUAL TO2 brain MRI lesions and GREATER-THAN OR EQUAL TO2 oligoclonal bands) enrolled in the Observational Study of Early Interferon β-1a Treatment in High Risk Subjects after CIS study (SET study), which prospectively evaluated the effect of intramuscular interferon β-1a treatment following the first demyelinating event. Thyroid stimulating hormone, free thyroxine, 25-hydroxy vitamin D3, active smoking status and body mass index were also obtained. Clinical and MRI assessments were obtained within 4 months of the initial demyelinating event and at 6, 12 and 24 months. Results: The time to first relapse and number of relapses were not associated with any of the lipid profile variables. Higher LDL-C (p=0.006) and TC (p=0.001) levels were associated with increased cumulative number of new T2 lesions over 2 years. Higher free thyroxine levels were associated with lower cumulative number of contrast-enhancing lesions (p=0.008). Higher TC was associated as a trend with lower baseline whole brain volume (p=0.020). Higher high density lipoprotein was associated with higher deseasonalised 1,25-dihydroxy vitamin D3 (p=0.003) levels and a trend was found for deseasonalised 25-hydroxy vitamin D3 (p=0.014). Conclusions: In early multiple sclerosis, lipid profile variables particularly LDL-C and TC levels are associated with inflammatory MRI activity measures.
dcterms:title
Lipid profiles are associated with lesion formation over 24 months in interferon-beta treated patients following the first demyelinating event Lipid profiles are associated with lesion formation over 24 months in interferon-beta treated patients following the first demyelinating event
skos:prefLabel
Lipid profiles are associated with lesion formation over 24 months in interferon-beta treated patients following the first demyelinating event Lipid profiles are associated with lesion formation over 24 months in interferon-beta treated patients following the first demyelinating event
skos:notation
RIV/00064165:_____/13:10193014!RIV14-MZ0-00064165
n12:predkladatel
n13:ico%3A00064165
n3:aktivita
n5:I n5:P n5:Z
n3:aktivity
I, P(NT13237), Z(MSM0021620849)
n3:cisloPeriodika
11
n3:dodaniDat
n6:2014
n3:domaciTvurceVysledku
n7:6857108 n7:4511042 n7:8895465 n7:8441456 n7:6253393 n7:8309213
n3:druhVysledku
n21:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
85057
n3:idVysledku
RIV/00064165:_____/13:10193014
n3:jazykVysledku
n20:eng
n3:klicovaSlova
Magnetic Resonance Imaging; Demyelinating Diseases; Czech Republic; Cohort Studies; Cholesterol, LDL; Cholesterol, HDL; Cholesterol; Calcifediol; Brain; Body Mass Index; Adult
n3:klicoveSlovo
n9:Calcifediol n9:Adult n9:Cohort%20Studies n9:Czech%20Republic n9:Brain n9:Body%20Mass%20Index n9:Cholesterol n9:LDL n9:HDL n9:Demyelinating%20Diseases n9:Magnetic%20Resonance%20Imaging
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[DD015265D6D0]
n3:nazevZdroje
Journal of Neurology, Neurosurgery and Psychiatry
n3:obor
n11:FH
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
18
n3:projekt
n19:NT13237
n3:rokUplatneniVysledku
n6:2013
n3:svazekPeriodika
84
n3:tvurceVysledku
Zivadinov, Robert Krásenský, Jan Seidl, Zdeněk Weinstock-Guttman, Bianca Havrdová, Eva Shyh, Grace Willis, Laura Hussein, Sarra O'Connor, Kerri Qu, Jun Tamano-Blanco, Miriam Ramanathan, Murali Badgett, Darlene Týblová, Michaela Bergsland, Niels Horáková, Dana Lakota, Elizabeth Vaněčková, Manuela
n3:wos
000329373100230
n3:zamer
n18:MSM0021620849
s:issn
0022-3050
s:numberOfPages
6
n8:doi
10.1136/jnnp-2012-304740