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Statements

Subject Item
n2:RIV%2F00064165%3A_____%2F13%3A10191882%21RIV14-MZ0-00064165
rdf:type
skos:Concept n7:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1155/2013/650694
dcterms:description
The aim of this study was to compare skin autofluorescence caused by advanced glycation end-products (AGEs) with biochemical markers of endothelial dysfunction and soluble receptor for AGEs (sRAGE) in patients with diabetes. Skin autofluorescence (AF) assessed by AGE-Reader was evaluated with sRAGE and other biochemical parameters in 88 patients with diabetes (47 Type 1/T1DM/ and 41 Type 2/T2DM/) and 20 controls. Skin AF was significantly higher in T1DM and T2DM in comparison to controls (2.39 +/- 0.54, 2.63 +/- 0.73 versus 1.96 +/- 0.33 AU; P < 0.0001). Positive correlation of AF with sRAGE was detected in T1DM and T2DM (r = 0.37, P < 0.02 and r = 0.60 P < 0.0001), but not in controls. Significantly higher AF values were found in patients with positive albuminuria as compared to those with normal albuminuria. Similarly, higher AF was detected in patients with endothelial dysfunction expressed by vWF, ICAM-1, and VCAM-1. Multiple regression analysis revealed independent association of skin AF with age, sRAGE, and albumin-creatinine ratio in patients with diabetes (R-2 = 0.38). Our study confirms that AF is elevated in patients with diabetes, especially with positive albuminuria and endothelial dysfunction. The strong and independent relationship between AF and sRAGE supports the idea that AF may reflect AGEs/RAGE interactions. The exact mechanism remains to be established. The aim of this study was to compare skin autofluorescence caused by advanced glycation end-products (AGEs) with biochemical markers of endothelial dysfunction and soluble receptor for AGEs (sRAGE) in patients with diabetes. Skin autofluorescence (AF) assessed by AGE-Reader was evaluated with sRAGE and other biochemical parameters in 88 patients with diabetes (47 Type 1/T1DM/ and 41 Type 2/T2DM/) and 20 controls. Skin AF was significantly higher in T1DM and T2DM in comparison to controls (2.39 +/- 0.54, 2.63 +/- 0.73 versus 1.96 +/- 0.33 AU; P < 0.0001). Positive correlation of AF with sRAGE was detected in T1DM and T2DM (r = 0.37, P < 0.02 and r = 0.60 P < 0.0001), but not in controls. Significantly higher AF values were found in patients with positive albuminuria as compared to those with normal albuminuria. Similarly, higher AF was detected in patients with endothelial dysfunction expressed by vWF, ICAM-1, and VCAM-1. Multiple regression analysis revealed independent association of skin AF with age, sRAGE, and albumin-creatinine ratio in patients with diabetes (R-2 = 0.38). Our study confirms that AF is elevated in patients with diabetes, especially with positive albuminuria and endothelial dysfunction. The strong and independent relationship between AF and sRAGE supports the idea that AF may reflect AGEs/RAGE interactions. The exact mechanism remains to be established.
dcterms:title
Skin Autofluorescence Relates to Soluble Receptor for Advanced Glycation End-Products and Albuminuria in Diabetes Mellitus Skin Autofluorescence Relates to Soluble Receptor for Advanced Glycation End-Products and Albuminuria in Diabetes Mellitus
skos:prefLabel
Skin Autofluorescence Relates to Soluble Receptor for Advanced Glycation End-Products and Albuminuria in Diabetes Mellitus Skin Autofluorescence Relates to Soluble Receptor for Advanced Glycation End-Products and Albuminuria in Diabetes Mellitus
skos:notation
RIV/00064165:_____/13:10191882!RIV14-MZ0-00064165
n7:predkladatel
n8:ico%3A00064165
n3:aktivita
n15:V n15:S n15:I
n3:aktivity
I, S, V
n3:cisloPeriodika
Mar 10
n3:dodaniDat
n14:2014
n3:domaciTvurceVysledku
n9:7406347 n9:8350132 n9:9660119 n9:6024378 n9:1825151 n9:8751706 n9:8705097 n9:6377165
n3:druhVysledku
n19:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
105408
n3:idVysledku
RIV/00064165:_____/13:10191882
n3:jazykVysledku
n17:eng
n3:klicovaSlova
disease; prediction; endproducts; nephropathy; pathogenesis; serum; rage; risk; endothelial-cells; microvascular complications
n3:klicoveSlovo
n5:microvascular%20complications n5:nephropathy n5:prediction n5:disease n5:endothelial-cells n5:pathogenesis n5:serum n5:risk n5:endproducts n5:rage
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[000E3EC2E251]
n3:nazevZdroje
Journal of Diabetes Research
n3:obor
n16:FB
n3:pocetDomacichTvurcuVysledku
8
n3:pocetTvurcuVysledku
9
n3:rokUplatneniVysledku
n14:2013
n3:svazekPeriodika
2013
n3:tvurceVysledku
Šoupal, Jan Škrha, Jan Kvasnička, Jan Ekali, G. Loni Kalousová, Marta Landová, Ludmila Prázný, Martin Zima, Tomáš
n3:wos
000318634500001
s:issn
2314-6745
s:numberOfPages
7
n18:doi
10.1155/2013/650694