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Statements

Subject Item
n2:RIV%2F00064165%3A_____%2F13%3A10190651%21RIV14-MZ0-00064165
rdf:type
skos:Concept n17:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.12659/MSM.889110
dcterms:description
Background: Cortisol is presumed to be a risk factor for stress-and age-related disorders, such as depressive disorder and Alzheimer's disease (AD). The aim of this study was to investigate the association of plasma cortisol concentration with AD in presence or absence of comorbid depressive symptoms. Material/Methods: Plasma cortisol concentration was measured in 80 AD patients (35 of them with depressive symptoms), 27 elderly depressive patients without AD, and 37 elderly controls. Results: Compared to controls, a significant increase of mean plasma cortisol was found in AD patients but not in depressive patients. Plasma cortisol was positively correlated with cognitive impairment in AD patients. We confirmed a U-shaped association between plasma cortisol and major depression and a linear association between plasma cortisol and AD without depressive symptoms. Significantly increased relative risk of disease in people with high plasma cortisol was found for AD with depressive symptoms and for AD with mild dementia. Conclusions: Plasma cortisol reflects the degree of cognitive impairment in AD rather than the severity of comorbid depression. We confirmed that both hypercortisolemia and hypocortisolemia are associated with depressive disorder. Significant association between high plasma cortisol and AD was found, supporting the use of high plasma cortisol as a component of a panel of biochemical markers for AD with depressive symptoms as well as AD in the early stage of dementia development. Background: Cortisol is presumed to be a risk factor for stress-and age-related disorders, such as depressive disorder and Alzheimer's disease (AD). The aim of this study was to investigate the association of plasma cortisol concentration with AD in presence or absence of comorbid depressive symptoms. Material/Methods: Plasma cortisol concentration was measured in 80 AD patients (35 of them with depressive symptoms), 27 elderly depressive patients without AD, and 37 elderly controls. Results: Compared to controls, a significant increase of mean plasma cortisol was found in AD patients but not in depressive patients. Plasma cortisol was positively correlated with cognitive impairment in AD patients. We confirmed a U-shaped association between plasma cortisol and major depression and a linear association between plasma cortisol and AD without depressive symptoms. Significantly increased relative risk of disease in people with high plasma cortisol was found for AD with depressive symptoms and for AD with mild dementia. Conclusions: Plasma cortisol reflects the degree of cognitive impairment in AD rather than the severity of comorbid depression. We confirmed that both hypercortisolemia and hypocortisolemia are associated with depressive disorder. Significant association between high plasma cortisol and AD was found, supporting the use of high plasma cortisol as a component of a panel of biochemical markers for AD with depressive symptoms as well as AD in the early stage of dementia development.
dcterms:title
Plasma cortisol in Alzheimer's disease with or without depressive symptoms Plasma cortisol in Alzheimer's disease with or without depressive symptoms
skos:prefLabel
Plasma cortisol in Alzheimer's disease with or without depressive symptoms Plasma cortisol in Alzheimer's disease with or without depressive symptoms
skos:notation
RIV/00064165:_____/13:10190651!RIV14-MZ0-00064165
n17:predkladatel
n18:ico%3A00064165
n3:aktivita
n12:I n12:S n12:Z
n3:aktivity
I, S, Z(MSM0021620849)
n3:cisloPeriodika
19
n3:dodaniDat
n4:2014
n3:domaciTvurceVysledku
n16:6189431 n16:7722672 n16:8854505 n16:9704132
n3:druhVysledku
n11:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
96406
n3:idVysledku
RIV/00064165:_____/13:10190651
n3:jazykVysledku
n15:eng
n3:klicovaSlova
cognitive impairment; depression; Alzheimer's disease; cortisol
n3:klicoveSlovo
n7:depression n7:cortisol n7:Alzheimer%27s%20disease n7:cognitive%20impairment
n3:kodStatuVydavatele
PL - Polská republika
n3:kontrolniKodProRIV
[F2AC3E21372C]
n3:nazevZdroje
Medical Science Monitor [online]
n3:obor
n19:FL
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n4:2013
n3:svazekPeriodika
Neuveden
n3:tvurceVysledku
Raboch, Jiří Fišar, Zdeněk Zvěřová, Martina Hroudová, Jana Jirák, Roman Kitzlerová, Eva
n3:wos
000323181300001
n3:zamer
n20:MSM0021620849
s:issn
1643-3750
s:numberOfPages
9
n8:doi
10.12659/MSM.889110