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Statements

Subject Item
n2:RIV%2F00064165%3A_____%2F13%3A10189581%21RIV14-MZ0-00064165
rdf:type
n7:Vysledek skos:Concept
rdfs:seeAlso
http://www.biomed.cas.cz/physiolres/pdf/62/62_463.pdf
dcterms:description
After global cerebral hypoxia, many patients are severely disabled even after intensive neurorehabilitation. Secondary mechanisms of brain injury as a result of biochemical and physiological events occur within a period of hours to months, and provide a window of opportunity for therapeutic intervention. Erythropoietin (EPO) has been shown to be neuroprotective in the brain subjected to a variety of injuries. Fifty-nine 3-month-old male Wistar rats were randomly distributed to experimental groups with respect to the housing (enriched environment - EE, standard housing - SH), to hypoxia exposure, and to EPO treatment. An acute mountain sickness model was used as a hypobaric hypoxia simulating an altitude of 8000 m. One half of the animals received erythropoietin injections, while the others were injected saline. Spatial memory was tested in a Morris water maze (MWM). The escape latency and the path length were measured. Better spatial learning in MWM was only seen in the group that received erythropoietin together with enriched environment. EPO administration itself had no influence on spatial memory. The results were very similar for both latencies and path lengths. These results support the idea that after brain injuries, the recovery can be potentiated by EPO administration combined with neurorehabilitation. After global cerebral hypoxia, many patients are severely disabled even after intensive neurorehabilitation. Secondary mechanisms of brain injury as a result of biochemical and physiological events occur within a period of hours to months, and provide a window of opportunity for therapeutic intervention. Erythropoietin (EPO) has been shown to be neuroprotective in the brain subjected to a variety of injuries. Fifty-nine 3-month-old male Wistar rats were randomly distributed to experimental groups with respect to the housing (enriched environment - EE, standard housing - SH), to hypoxia exposure, and to EPO treatment. An acute mountain sickness model was used as a hypobaric hypoxia simulating an altitude of 8000 m. One half of the animals received erythropoietin injections, while the others were injected saline. Spatial memory was tested in a Morris water maze (MWM). The escape latency and the path length were measured. Better spatial learning in MWM was only seen in the group that received erythropoietin together with enriched environment. EPO administration itself had no influence on spatial memory. The results were very similar for both latencies and path lengths. These results support the idea that after brain injuries, the recovery can be potentiated by EPO administration combined with neurorehabilitation.
dcterms:title
Long-Term Results of Enriched Environment and Erythropoietin After Hypobaric Hypoxia in Rats Long-Term Results of Enriched Environment and Erythropoietin After Hypobaric Hypoxia in Rats
skos:prefLabel
Long-Term Results of Enriched Environment and Erythropoietin After Hypobaric Hypoxia in Rats Long-Term Results of Enriched Environment and Erythropoietin After Hypobaric Hypoxia in Rats
skos:notation
RIV/00064165:_____/13:10189581!RIV14-MZ0-00064165
n7:predkladatel
n15:ico%3A00064165
n4:aktivita
n17:V n17:I
n4:aktivity
I, V
n4:cisloPeriodika
4
n4:dodaniDat
n5:2014
n4:domaciTvurceVysledku
n8:2071347 n8:8705097 n8:6302157 n8:8928800
n4:druhVysledku
n18:J
n4:duvernostUdaju
n16:S
n4:entitaPredkladatele
n12:predkladatel
n4:idSjednocenehoVysledku
85410
n4:idVysledku
RIV/00064165:_____/13:10189581
n4:jazykVysledku
n6:eng
n4:klicovaSlova
Spatial memory; Morris water maze; Erythropoietin; Enriched environment; Global cerebral hypoxia
n4:klicoveSlovo
n11:Erythropoietin n11:Spatial%20memory n11:Enriched%20environment n11:Global%20cerebral%20hypoxia n11:Morris%20water%20maze
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[078BC462BC2A]
n4:nazevZdroje
Physiological Research
n4:obor
n10:ED
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
7
n4:rokUplatneniVysledku
n5:2013
n4:svazekPeriodika
62
n4:tvurceVysledku
Lippertová-Grünerová, Marcela Zima, Tomáš Bortelová, Jana Angerová, Yvona Švestková, Olga Gueye, Tereza Hralová, Michaela
n4:wos
000323510500014
s:issn
0862-8408
s:numberOfPages
8