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Statements

Subject Item
n2:RIV%2F00064165%3A_____%2F13%3A10189495%21RIV14-MZ0-00064165
rdf:type
n4:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1186/1479-5876-11-124
dcterms:description
Background: Mild therapeutic hypothermia (HT) has been implemented in the management of post cardiac arrest (CA) syndrome after the publication of clinical trials comparing HT with common practice (ie, usually hyperthermia). Current evidence on the comparison between therapeutic HT and controlled normothermia (NT) in CA survivors, however, remains insufficient. Methods: Eight female swine (sus scrofa domestica; body weight 45 kg) were randomly assigned to receive either mild therapeutic HT or controlled NT, with four animals per group. Veno-arterial extracorporeal membrane oxygenation (ECMO) was established and at minimal ECMO flow (0.5 L/min) ventricular fibrillation was induced by rapid ventricular pacing. After 20 min of CA, circulation was restored by increasing the ECMO flow to 4.5 L/min; 90 min of reperfusion followed. Target core temperatures (HT: 33 degrees C; NT: 36.8 degrees C) were maintained using the heat exchanger on the oxygenator. Invasive blood pressure was measured in the aortic arch, and cerebral oxygenation was assessed using near-infrared spectroscopy. After 60 min of reperfusion, up to three defibrillation attempts were performed. After 90 min of reperfusion, blood samples were drawn for the measurement of troponin I (TnI), myoglobin (MGB), creatine-phosphokinase (CPK), alanin-aminotransferase (ALT), neuron-specific enolase (NSE) and cystatin C (CysC) levels. Reactive oxygen metabolite (ROM) levels and biological antioxidant potential (BAP) were also measured. Results: Significantly higher blood pressure and cerebral oxygenation values were observed in the HT group (P<0.05). Sinus rhythm was restored in all of the HT animals and in one from the NT group. The levels of TnI, MGB, CPK, ALT, and ROM were significantly lower in the HT group (P<0.05); levels of NSE, CysC, and BAP were comparable in both groups. Background: Mild therapeutic hypothermia (HT) has been implemented in the management of post cardiac arrest (CA) syndrome after the publication of clinical trials comparing HT with common practice (ie, usually hyperthermia). Current evidence on the comparison between therapeutic HT and controlled normothermia (NT) in CA survivors, however, remains insufficient. Methods: Eight female swine (sus scrofa domestica; body weight 45 kg) were randomly assigned to receive either mild therapeutic HT or controlled NT, with four animals per group. Veno-arterial extracorporeal membrane oxygenation (ECMO) was established and at minimal ECMO flow (0.5 L/min) ventricular fibrillation was induced by rapid ventricular pacing. After 20 min of CA, circulation was restored by increasing the ECMO flow to 4.5 L/min; 90 min of reperfusion followed. Target core temperatures (HT: 33 degrees C; NT: 36.8 degrees C) were maintained using the heat exchanger on the oxygenator. Invasive blood pressure was measured in the aortic arch, and cerebral oxygenation was assessed using near-infrared spectroscopy. After 60 min of reperfusion, up to three defibrillation attempts were performed. After 90 min of reperfusion, blood samples were drawn for the measurement of troponin I (TnI), myoglobin (MGB), creatine-phosphokinase (CPK), alanin-aminotransferase (ALT), neuron-specific enolase (NSE) and cystatin C (CysC) levels. Reactive oxygen metabolite (ROM) levels and biological antioxidant potential (BAP) were also measured. Results: Significantly higher blood pressure and cerebral oxygenation values were observed in the HT group (P<0.05). Sinus rhythm was restored in all of the HT animals and in one from the NT group. The levels of TnI, MGB, CPK, ALT, and ROM were significantly lower in the HT group (P<0.05); levels of NSE, CysC, and BAP were comparable in both groups.
dcterms:title
Mild therapeutic hypothermia is superior to controlled normothermia for the maintenance of blood pressure and cerebral oxygenation, prevention of organ damage and suppression of oxidative stress after cardiac arrest in a porcine model Mild therapeutic hypothermia is superior to controlled normothermia for the maintenance of blood pressure and cerebral oxygenation, prevention of organ damage and suppression of oxidative stress after cardiac arrest in a porcine model
skos:prefLabel
Mild therapeutic hypothermia is superior to controlled normothermia for the maintenance of blood pressure and cerebral oxygenation, prevention of organ damage and suppression of oxidative stress after cardiac arrest in a porcine model Mild therapeutic hypothermia is superior to controlled normothermia for the maintenance of blood pressure and cerebral oxygenation, prevention of organ damage and suppression of oxidative stress after cardiac arrest in a porcine model
skos:notation
RIV/00064165:_____/13:10189495!RIV14-MZ0-00064165
n4:predkladatel
n12:ico%3A00064165
n3:aktivita
n13:I
n3:aktivity
I
n3:cisloPeriodika
May
n3:dodaniDat
n8:2014
n3:domaciTvurceVysledku
n11:4894596
n3:druhVysledku
n15:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
88377
n3:idVysledku
RIV/00064165:_____/13:10189495
n3:jazykVysledku
n19:eng
n3:klicovaSlova
Oxidative stress; Organ protection; Blood pressure; Cerebral oxygenation; Extracorporeal membrane oxygenation; Post-cardiac arrest syndrome; Normothermia; Mild hypothermia; Cardiac arrest
n3:klicoveSlovo
n5:Oxidative%20stress n5:Cerebral%20oxygenation n5:Mild%20hypothermia n5:Extracorporeal%20membrane%20oxygenation n5:Organ%20protection n5:Blood%20pressure n5:Cardiac%20arrest n5:Post-cardiac%20arrest%20syndrome n5:Normothermia
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[91D3AE0F825D]
n3:nazevZdroje
Journal of Translational Medicine
n3:obor
n18:FA
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
14
n3:rokUplatneniVysledku
n8:2013
n3:svazekPeriodika
11
n3:tvurceVysledku
Dudkova, Vlasta Kruger, Andreas Svoboda, Tomáš Kittnar, Otomar Skabradova, Marcela Bělohlávek, Jan Mlček, Mikuláš Hrachovina, Vladimír Taborsky, Ludek Holy, František Horakova, Svatava Psotova, Hana Ostadal, Petr Neužil, Petr
n3:wos
000320047800001
s:issn
1479-5876
s:numberOfPages
7
n17:doi
10.1186/1479-5876-11-124