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Statements

Subject Item
n2:RIV%2F00064165%3A_____%2F13%3A10189418%21RIV14-MZ0-00064165
rdf:type
n13:Vysledek skos:Concept
rdfs:seeAlso
http://www.biomed.cas.cz/physiolres/pdf/62/62_27.pdf
dcterms:description
Aprotinin, a nonspecific serine protease inhibitor, has been primarily used as a haemostatic drug in cardiac surgery with cardio-pulmonary bypass (CPB). This study investigated the effect of Aprotinin on the post-operative levels of procalcitonin (PCT) and a set of cytokines in patients undergoing pulmonary artery endarterectomy (PEA). We analyzed 60 patients with chronic thromboembolic pulmonary hypertension undergoing PEA. 30 patients (Group A) were treated with Aprotinin (2000000 IU prior anesthesia, then 2000000 IU in CPB prime and 50000 IU per hour continuously); a further 30 patients (Group B) received Tranexamic Acid (1 g before anesthesia, 1 g after full heparin dose and 2 g in CPB prime). PCT, TNF alpha, IL-1 beta, IL-6, and IL-8 arterial concentrations were measured from before until 72 hours after surgery. Aprotinin significantly affected early post-PEA plasma PCT. Patients treated with Aprotinin (Group A) had lower peak PCT levels compared to patients in Group B (1.52 ng/ml versus 2.18, p=0.024). Postoperative peak values of PCT and IL-6 correlated closely in both groups (r=0.78, r=0.83 respectively). Aprotinin attenuates the post-PEA increase of PCT in the same manner as other pro-inflammatory cytokines. Significant correlation between PCT and IL-6 post-surgery may be indicative of an indirect IL-6-mediated pathway of PCT alteration. Aprotinin, a nonspecific serine protease inhibitor, has been primarily used as a haemostatic drug in cardiac surgery with cardio-pulmonary bypass (CPB). This study investigated the effect of Aprotinin on the post-operative levels of procalcitonin (PCT) and a set of cytokines in patients undergoing pulmonary artery endarterectomy (PEA). We analyzed 60 patients with chronic thromboembolic pulmonary hypertension undergoing PEA. 30 patients (Group A) were treated with Aprotinin (2000000 IU prior anesthesia, then 2000000 IU in CPB prime and 50000 IU per hour continuously); a further 30 patients (Group B) received Tranexamic Acid (1 g before anesthesia, 1 g after full heparin dose and 2 g in CPB prime). PCT, TNF alpha, IL-1 beta, IL-6, and IL-8 arterial concentrations were measured from before until 72 hours after surgery. Aprotinin significantly affected early post-PEA plasma PCT. Patients treated with Aprotinin (Group A) had lower peak PCT levels compared to patients in Group B (1.52 ng/ml versus 2.18, p=0.024). Postoperative peak values of PCT and IL-6 correlated closely in both groups (r=0.78, r=0.83 respectively). Aprotinin attenuates the post-PEA increase of PCT in the same manner as other pro-inflammatory cytokines. Significant correlation between PCT and IL-6 post-surgery may be indicative of an indirect IL-6-mediated pathway of PCT alteration.
dcterms:title
Aprotinin Reduces the Procalcitonin Rise Associated With Complex Cardiac Surgery and Cardiopulmonary Bypass Aprotinin Reduces the Procalcitonin Rise Associated With Complex Cardiac Surgery and Cardiopulmonary Bypass
skos:prefLabel
Aprotinin Reduces the Procalcitonin Rise Associated With Complex Cardiac Surgery and Cardiopulmonary Bypass Aprotinin Reduces the Procalcitonin Rise Associated With Complex Cardiac Surgery and Cardiopulmonary Bypass
skos:notation
RIV/00064165:_____/13:10189418!RIV14-MZ0-00064165
n13:predkladatel
n14:ico%3A00064165
n5:aktivita
n10:V n10:P
n5:aktivity
P(NT11210), V
n5:cisloPeriodika
1
n5:dodaniDat
n8:2014
n5:domaciTvurceVysledku
n6:8736677 n6:5624088 n6:7157991 n6:9548270
n5:druhVysledku
n12:J
n5:duvernostUdaju
n7:S
n5:entitaPredkladatele
n18:predkladatel
n5:idSjednocenehoVysledku
61903
n5:idVysledku
RIV/00064165:_____/13:10189418
n5:jazykVysledku
n17:eng
n5:klicovaSlova
Pulmonary endarterectomy; Procalcitonin; Cardiopulmonary bypass; Aprotinin
n5:klicoveSlovo
n9:Procalcitonin n9:Aprotinin n9:Cardiopulmonary%20bypass n9:Pulmonary%20endarterectomy
n5:kodStatuVydavatele
CZ - Česká republika
n5:kontrolniKodProRIV
[E236BF7A2D15]
n5:nazevZdroje
Physiological Research
n5:obor
n15:FA
n5:pocetDomacichTvurcuVysledku
4
n5:pocetTvurcuVysledku
6
n5:projekt
n16:NT11210
n5:rokUplatneniVysledku
n8:2013
n5:svazekPeriodika
62
n5:tvurceVysledku
Maruna, Pavel Kunstýř, Jan Klein, A. A. Plocová, Kateřina Magdaléna Lindner, Jaroslav Mlejnský, František
n5:wos
000317958500004
s:issn
0862-8408
s:numberOfPages
7