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Statements

Subject Item
n2:RIV%2F00064165%3A_____%2F13%3A10173666%21RIV14-MZ0-00064165
rdf:type
n4:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1186/1471-2369-14-142
dcterms:description
Background: Placental growth factor [PlGF) is a cardiovascular (CV) risk marker, which is related to left ventricle hypertrophy (LVH) in animal models. Currently there are no data available regarding the possible relationship of PlGF and the development of LVH or diastolic dysfunction in patients with chronic kidney disease (CKD) and the relationship of PlGF to other CV risk factors in CKD patients. The aim of our study was to determine the possible association of PlGF and several other CV risk markers to echocardiographic parameters in CKD population. Methods: We prospectively examined selected laboratory (PlGF, fibroblast growth factor-23 -FGF23, vitamin D, parathyroid hormone, extracellular newly identified RAGE-binding protein - EN-RAGE, B-type natriuretic peptide - BNP) and echocardiographic parameters in 62 patients with CKD 2-4. Mean follow-up was 36 +/- 10 months. Laboratory and echocardiographic data were collected 2-3 times, at the shortest interval of 12 months apart. Multivariate regression analysis was used to detect independent correlations of variables. Results: Increased left ventricular mass index (LVMI, g/m(2.7)) was found in 29% patients with CKD 2-4, left ventricular (LV) diastolic dysfunction was detected in 74.1% patients (impaired LV relaxation in 43.5% patients and pseudonormal pattern in 30.6% patients). After 36 +/- 10 months increased LVMI was found in 37.1% patients with CKD 2-4, LV diastolic dysfunction was detected in 75.8% patients (impaired LV relaxation in 43.5% patients and pseudonormal pattern in 32.3% patients). Following independent correlations were found: LVMI was related to PlGF, cholesterol, BNP, systolic blood pressure and serum creatinine. Background: Placental growth factor [PlGF) is a cardiovascular (CV) risk marker, which is related to left ventricle hypertrophy (LVH) in animal models. Currently there are no data available regarding the possible relationship of PlGF and the development of LVH or diastolic dysfunction in patients with chronic kidney disease (CKD) and the relationship of PlGF to other CV risk factors in CKD patients. The aim of our study was to determine the possible association of PlGF and several other CV risk markers to echocardiographic parameters in CKD population. Methods: We prospectively examined selected laboratory (PlGF, fibroblast growth factor-23 -FGF23, vitamin D, parathyroid hormone, extracellular newly identified RAGE-binding protein - EN-RAGE, B-type natriuretic peptide - BNP) and echocardiographic parameters in 62 patients with CKD 2-4. Mean follow-up was 36 +/- 10 months. Laboratory and echocardiographic data were collected 2-3 times, at the shortest interval of 12 months apart. Multivariate regression analysis was used to detect independent correlations of variables. Results: Increased left ventricular mass index (LVMI, g/m(2.7)) was found in 29% patients with CKD 2-4, left ventricular (LV) diastolic dysfunction was detected in 74.1% patients (impaired LV relaxation in 43.5% patients and pseudonormal pattern in 30.6% patients). After 36 +/- 10 months increased LVMI was found in 37.1% patients with CKD 2-4, LV diastolic dysfunction was detected in 75.8% patients (impaired LV relaxation in 43.5% patients and pseudonormal pattern in 32.3% patients). Following independent correlations were found: LVMI was related to PlGF, cholesterol, BNP, systolic blood pressure and serum creatinine.
dcterms:title
Placental growth factor may predict increased left ventricular mass index in patients with mild to moderate chronic kidney disease - a prospective observational study Placental growth factor may predict increased left ventricular mass index in patients with mild to moderate chronic kidney disease - a prospective observational study
skos:prefLabel
Placental growth factor may predict increased left ventricular mass index in patients with mild to moderate chronic kidney disease - a prospective observational study Placental growth factor may predict increased left ventricular mass index in patients with mild to moderate chronic kidney disease - a prospective observational study
skos:notation
RIV/00064165:_____/13:10173666!RIV14-MZ0-00064165
n4:predkladatel
n5:ico%3A00064165
n3:aktivita
n17:I
n3:aktivity
I
n3:cisloPeriodika
JUL
n3:dodaniDat
n10:2014
n3:domaciTvurceVysledku
n7:9360557 n7:3615332 n7:5023831 n7:2957566 n7:7324049 n7:8002177 n7:6377165 n7:2455404 n7:6121179 n7:8705097
n3:druhVysledku
n14:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
96332
n3:idVysledku
RIV/00064165:_____/13:10173666
n3:jazykVysledku
n18:eng
n3:klicovaSlova
Left ventricular hypertrophy; Left ventricular mass index; Extracellular newly identified RAGE-binding protein (EN-RAGE); Echocardiography; Chronic kidney disease; Cardiovascular disease
n3:klicoveSlovo
n8:Echocardiography n8:Left%20ventricular%20hypertrophy n8:Extracellular%20newly%20identified%20RAGE-binding%20protein%20%28EN-RAGE%29 n8:Left%20ventricular%20mass%20index n8:Chronic%20kidney%20disease n8:Cardiovascular%20disease
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[350686D31262]
n3:nazevZdroje
BMC Nephrology
n3:obor
n12:FE
n3:pocetDomacichTvurcuVysledku
10
n3:pocetTvurcuVysledku
12
n3:rokUplatneniVysledku
n10:2013
n3:svazekPeriodika
14
n3:tvurceVysledku
Peiskerová, Martina Zima, Tomáš Hodková, Magdaléna Míková, Blanka Tesař, Vladimír Ambrož, David Danzig, Vilém Němeček, Eduard Linhart, Aleš Benáková, Hana Kalousová, Marta Bani Hani, Amjad
n3:wos
000322922500001
s:issn
1471-2369
s:numberOfPages
9
n19:doi
10.1186/1471-2369-14-142