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Statements

Subject Item
n2:RIV%2F00064165%3A_____%2F13%3A10172687%21RIV14-MZ0-00064165
rdf:type
skos:Concept n14:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1210/jc.2012-3625
dcterms:description
Context: Catecholamine overproduction in pheochromocytoma affects basal metabolism, resulting in weight loss despite normal food intake. Objective: The objective of the study was to evaluate changes in energy metabolism expressed as resting energy expenditure (REE) in patients with pheochromocytoma before and after adrenalectomy and the possible relationship with circulating inflammatory markers. Design: We measured REE in 17 patients (8 women) with pheochromocytoma by indirect calorimetry (Vmax-Encore 29N system) before and 1 year after adrenalectomy. Body fat percentage was measured with a Bodystat device. Inflammatory markers (leukocytes count and C-reactive protein) and cytokines (TNF-alpha, IL-6, and IL-8) were analyzed with a Luminex 200. Results: REE measured in the pheochromocytoma group was 10.4% higher than the predicted value (1731 +/- 314 vs 1581 +/- 271 kcal/d; P = .004). Adrenalectomy significantly increased body mass index (P = 0.004) and the percentage of body fat (P = .01), with a proportional increase in fat distribution (waist circumference, P = .045; hip circumference, P = .001). REE significantly decreased after adrenalectomy (1731 +/- 314 vs 1539 +/- 215 kcal/d; P = .002), even after adjustments in body surface and body weight (P < .001). After adrenalectomy, we found a significant decrease in leukocyte counts (P = .014) and in the levels of TNF-alpha (P < .001), IL-6 (P = .048), and IL-8 (P = .007) but not C-reactive protein (P = .09). No significant correlations among calorimetry parameters, hormones, and proinflammatory markers were detected. Conclusions: Chronic catecholamine overproduction in pheochromocytoma may lead to a proinflammatory and hypermetabolic state characterized by increased REE. Adrenalectomy leads to the normalization of energy metabolism followed by an increase in body mass index and body fat content and decreases in inflammatory markers and cytokines. (J Clin Endocrinol Metab 98: 1651-1658, 2013) Context: Catecholamine overproduction in pheochromocytoma affects basal metabolism, resulting in weight loss despite normal food intake. Objective: The objective of the study was to evaluate changes in energy metabolism expressed as resting energy expenditure (REE) in patients with pheochromocytoma before and after adrenalectomy and the possible relationship with circulating inflammatory markers. Design: We measured REE in 17 patients (8 women) with pheochromocytoma by indirect calorimetry (Vmax-Encore 29N system) before and 1 year after adrenalectomy. Body fat percentage was measured with a Bodystat device. Inflammatory markers (leukocytes count and C-reactive protein) and cytokines (TNF-alpha, IL-6, and IL-8) were analyzed with a Luminex 200. Results: REE measured in the pheochromocytoma group was 10.4% higher than the predicted value (1731 +/- 314 vs 1581 +/- 271 kcal/d; P = .004). Adrenalectomy significantly increased body mass index (P = 0.004) and the percentage of body fat (P = .01), with a proportional increase in fat distribution (waist circumference, P = .045; hip circumference, P = .001). REE significantly decreased after adrenalectomy (1731 +/- 314 vs 1539 +/- 215 kcal/d; P = .002), even after adjustments in body surface and body weight (P < .001). After adrenalectomy, we found a significant decrease in leukocyte counts (P = .014) and in the levels of TNF-alpha (P < .001), IL-6 (P = .048), and IL-8 (P = .007) but not C-reactive protein (P = .09). No significant correlations among calorimetry parameters, hormones, and proinflammatory markers were detected. Conclusions: Chronic catecholamine overproduction in pheochromocytoma may lead to a proinflammatory and hypermetabolic state characterized by increased REE. Adrenalectomy leads to the normalization of energy metabolism followed by an increase in body mass index and body fat content and decreases in inflammatory markers and cytokines. (J Clin Endocrinol Metab 98: 1651-1658, 2013)
dcterms:title
Changes in Energy Metabolism in Pheochromocytoma Changes in Energy Metabolism in Pheochromocytoma
skos:prefLabel
Changes in Energy Metabolism in Pheochromocytoma Changes in Energy Metabolism in Pheochromocytoma
skos:notation
RIV/00064165:_____/13:10172687!RIV14-MZ0-00064165
n14:predkladatel
n15:ico%3A00064165
n3:aktivita
n4:I n4:P
n3:aktivity
I, P(NT12336), P(NT13046)
n3:cisloPeriodika
4
n3:dodaniDat
n8:2014
n3:domaciTvurceVysledku
n9:9838570 n9:6061982 n9:1128469 n9:8498326 n9:8830207 n9:4834739 n9:9125035 n9:1126431 n9:2203278 n9:4934091
n3:druhVysledku
n19:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
64919
n3:idVysledku
RIV/00064165:_____/13:10172687
n3:jazykVysledku
n11:eng
n3:klicovaSlova
expenditure; catecholamines; cachexia; oxidation; hypertension; epinephrine; humans; inflammatory mediators; factor-alpha; tumor-necrosis-factor
n3:klicoveSlovo
n6:tumor-necrosis-factor n6:inflammatory%20mediators n6:cachexia n6:humans n6:expenditure n6:factor-alpha n6:epinephrine n6:catecholamines n6:hypertension n6:oxidation
n3:kodStatuVydavatele
EG - Egyptská arabská republika
n3:kontrolniKodProRIV
[036B77D5F503]
n3:nazevZdroje
Journal of Clinical Endocrinology and Metabolism
n3:obor
n20:FB
n3:pocetDomacichTvurcuVysledku
10
n3:pocetTvurcuVysledku
11
n3:projekt
n12:NT13046 n12:NT12336
n3:rokUplatneniVysledku
n8:2013
n3:svazekPeriodika
98
n3:tvurceVysledku
Petrák, Ondřej Brabcová Vránková, Alice Rosa, Ján Haluzíková, Denisa Holaj, Robert Michalský, David Zelinka, Tomáš Kaválková, Petra Štrauch, Branislav Haluzík, Martin Widimský, Jiří
n3:wos
000317195600070
s:issn
0021-972X
s:numberOfPages
8
n18:doi
10.1210/jc.2012-3625