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Statements

Subject Item
n2:RIV%2F00064165%3A_____%2F12%3A13021%21RIV13-MZ0-00064165
rdf:type
skos:Concept n7:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.3389/fphar.2012.00055
dcterms:description
Bilirubin belongs to a phylogenetically old superfamily of tetrapyrrolic compounds, which have multiple biological functions. Although for decades bilirubin was believed to be only awaste product of the heme catabolic pathway at best, and a potentially toxic compound at worst; recent data has convincingly demonstrated that mildly elevated serum bilirubin levels are strongly associated with a lower prevalence of oxidative stress-mediated diseases. Indeed, serum bilirubin has been consistently shown to be negatively correlated to cardiovascular diseases, as well as to related diseases and risk factors such as arterial hypertension, diabetes mellitus, metabolic syndrome, and obesity. Bilirubin belongs to a phylogenetically old superfamily of tetrapyrrolic compounds, which have multiple biological functions. Although for decades bilirubin was believed to be only awaste product of the heme catabolic pathway at best, and a potentially toxic compound at worst; recent data has convincingly demonstrated that mildly elevated serum bilirubin levels are strongly associated with a lower prevalence of oxidative stress-mediated diseases. Indeed, serum bilirubin has been consistently shown to be negatively correlated to cardiovascular diseases, as well as to related diseases and risk factors such as arterial hypertension, diabetes mellitus, metabolic syndrome, and obesity.
dcterms:title
The role of bilirubin in diabetes, metabolic syndrome, and cardiovascular diseases The role of bilirubin in diabetes, metabolic syndrome, and cardiovascular diseases
skos:prefLabel
The role of bilirubin in diabetes, metabolic syndrome, and cardiovascular diseases The role of bilirubin in diabetes, metabolic syndrome, and cardiovascular diseases
skos:notation
RIV/00064165:_____/12:13021!RIV13-MZ0-00064165
n7:predkladatel
n8:ico%3A00064165
n3:aktivita
n13:P
n3:aktivity
P(GAP206/11/0836), P(LH11030), P(NS9770)
n3:cisloPeriodika
Articles 55
n3:dodaniDat
n14:2013
n3:domaciTvurceVysledku
n15:2025876
n3:druhVysledku
n12:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
165971
n3:idVysledku
RIV/00064165:_____/12:13021
n3:jazykVysledku
n17:eng
n3:klicovaSlova
Bilirubin; biliverdin; biliverdin reductase; cardiovascular disease; diabetes mellitus; metabolic syndrome; heme oxygenase; UGT1A1
n3:klicoveSlovo
n4:heme%20oxygenase n4:metabolic%20syndrome n4:UGT1A1 n4:diabetes%20mellitus n4:biliverdin%20reductase n4:biliverdin n4:Bilirubin n4:cardiovascular%20disease
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[E42173A34CD4]
n3:nazevZdroje
Frontiers in Pharmacology
n3:obor
n11:FB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
1
n3:projekt
n18:GAP206%2F11%2F0836 n18:LH11030 n18:NS9770
n3:rokUplatneniVysledku
n14:2012
n3:svazekPeriodika
3
n3:tvurceVysledku
Vítek, Libor
s:issn
1663-9812
s:numberOfPages
7