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Statements

Subject Item
n2:RIV%2F00064165%3A_____%2F12%3A12353%21RIV13-MZ0-00064165
rdf:type
skos:Concept n12:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1016/j.cyto.2012.02.003
dcterms:description
Adiponectin was initially described as a regulator of metabolic homeostases. Further studies demonstrated its involvement in the regulation of inflammatory diseases, particularly rheumatic and vascular diseases and some fibrotic processes. The aim of this study was to evaluate adiponectin in the circulation of patients with systemic sclerosis (SSc) and characterise its potential association with skin changes and SSc-related features.Adiponectin serum levels were similar between patients with SSc and healthy controls. Levels of serum adiponectin were negatively correlated with the skin score. Regression analysis of the relationship between adiponectin and markers of interest provided two statistically significant models: A- with explanatory variables HDL-cholesterol, skin score, disease duration, age (R(2)=0.580); and B- with CRP, skin score, age in order of a decreasing influence. Based on the results of this study, it might be speculated that adiponectin plays a protective role in skin- and atherosclerosis-related changes during SSc Adiponectin was initially described as a regulator of metabolic homeostases. Further studies demonstrated its involvement in the regulation of inflammatory diseases, particularly rheumatic and vascular diseases and some fibrotic processes. The aim of this study was to evaluate adiponectin in the circulation of patients with systemic sclerosis (SSc) and characterise its potential association with skin changes and SSc-related features.Adiponectin serum levels were similar between patients with SSc and healthy controls. Levels of serum adiponectin were negatively correlated with the skin score. Regression analysis of the relationship between adiponectin and markers of interest provided two statistically significant models: A- with explanatory variables HDL-cholesterol, skin score, disease duration, age (R(2)=0.580); and B- with CRP, skin score, age in order of a decreasing influence. Based on the results of this study, it might be speculated that adiponectin plays a protective role in skin- and atherosclerosis-related changes during SSc
dcterms:title
Adiponectin relation to skin changes and dyslipidemia in systemic sclerosis Adiponectin relation to skin changes and dyslipidemia in systemic sclerosis
skos:prefLabel
Adiponectin relation to skin changes and dyslipidemia in systemic sclerosis Adiponectin relation to skin changes and dyslipidemia in systemic sclerosis
skos:notation
RIV/00064165:_____/12:12353!RIV13-MZ0-00064165
n12:predkladatel
n15:ico%3A00064165
n3:aktivita
n14:S n14:I
n3:aktivity
I, S
n3:cisloPeriodika
2
n3:dodaniDat
n6:2013
n3:domaciTvurceVysledku
n8:6061982 n8:8696713
n3:druhVysledku
n13:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
121112
n3:idVysledku
RIV/00064165:_____/12:12353
n3:jazykVysledku
n16:eng
n3:klicovaSlova
adiponectin; systemic sclerosis; skin score
n3:klicoveSlovo
n7:skin%20score n7:systemic%20sclerosis n7:adiponectin
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[4B599B2EED41]
n3:nazevZdroje
Cytokine
n3:obor
n17:FE
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
15
n3:rokUplatneniVysledku
n6:2012
n3:svazekPeriodika
58
n3:tvurceVysledku
Müller-Ladner, U. Novák, Marek Vencovský, Jiří Kuklová, Markéta Haluzík, Martin Filková, Mária Tomčík, Michal Bečvář, Radim Gay, S. Běláček, Jaromír Šenolt, Ladislav Distler, O. Braun, Martin Arima, Kazuhiko Hulejova, Hana
n3:wos
000303099200006
s:issn
1043-4666
s:numberOfPages
4