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Statements

Subject Item
n2:RIV%2F00064165%3A_____%2F12%3A11831%21RIV13-MZ0-00064165
rdf:type
skos:Concept n11:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1371/journal.pone.0050101
dcterms:description
Objectives: To compare clinical and MRI parameters between patients with clinically isolated syndrome and those converting to clinically definite multiple sclerosis within 2 years, to identify volumetric MRI predictors of this conversion and to assess effect of early relapses. Methods: The SET study comprised 220 patients with clinically isolated syndrome treated with interferon beta (mean age, 29 years; Expanded Disability Status Scale, 1.5). Three patients with missing data were excluded from the analysis. Physical disability, time to clinically definite multiple sclerosis and volumetric MRI data were recorded for 2 years. Results: Patients reaching clinically definite multiple sclerosis showed impaired recovery of neurological function, faster decrease in corpus callosum cross-sectional area, higher T2 lesion volume and more contrast-enhancing lesions. Six-month decrease in corpus callosum cross-sectional area (>= 1%) and baseline T2 lesion volume (>= 5 cm(3)) predicted clinically definite multiple sclerosis within 2 years (hazard ratios 2.5 and 1.8, respectively). Of 22 patients fulfilling both predictive criteria, 83% reached clinically definite multiple sclerosis (hazard ratio 6.5). More relapses were associated with poorer recovery of neurological function and accelerated brain atrophy. Conclusions: Neurological impairment is more permanent, brain atrophy is accelerated and focal inflammatory activity is greater in patients converting to clinically definite multiple sclerosis. Six-month corpus callosum atrophy and baseline T2 lesion volume jointly help predict individual risk of clinically definite multiple sclerosis. Early relapses contribute to permanent damage of the central nervous system. Objectives: To compare clinical and MRI parameters between patients with clinically isolated syndrome and those converting to clinically definite multiple sclerosis within 2 years, to identify volumetric MRI predictors of this conversion and to assess effect of early relapses. Methods: The SET study comprised 220 patients with clinically isolated syndrome treated with interferon beta (mean age, 29 years; Expanded Disability Status Scale, 1.5). Three patients with missing data were excluded from the analysis. Physical disability, time to clinically definite multiple sclerosis and volumetric MRI data were recorded for 2 years. Results: Patients reaching clinically definite multiple sclerosis showed impaired recovery of neurological function, faster decrease in corpus callosum cross-sectional area, higher T2 lesion volume and more contrast-enhancing lesions. Six-month decrease in corpus callosum cross-sectional area (>= 1%) and baseline T2 lesion volume (>= 5 cm(3)) predicted clinically definite multiple sclerosis within 2 years (hazard ratios 2.5 and 1.8, respectively). Of 22 patients fulfilling both predictive criteria, 83% reached clinically definite multiple sclerosis (hazard ratio 6.5). More relapses were associated with poorer recovery of neurological function and accelerated brain atrophy. Conclusions: Neurological impairment is more permanent, brain atrophy is accelerated and focal inflammatory activity is greater in patients converting to clinically definite multiple sclerosis. Six-month corpus callosum atrophy and baseline T2 lesion volume jointly help predict individual risk of clinically definite multiple sclerosis. Early relapses contribute to permanent damage of the central nervous system.
dcterms:title
Volumetric MRI Markers and Predictors of Disease Activity in Early Multiple Sclerosis: A Longitudinal Cohort Study Volumetric MRI Markers and Predictors of Disease Activity in Early Multiple Sclerosis: A Longitudinal Cohort Study
skos:prefLabel
Volumetric MRI Markers and Predictors of Disease Activity in Early Multiple Sclerosis: A Longitudinal Cohort Study Volumetric MRI Markers and Predictors of Disease Activity in Early Multiple Sclerosis: A Longitudinal Cohort Study
skos:notation
RIV/00064165:_____/12:11831!RIV13-MZ0-00064165
n11:predkladatel
n12:ico%3A00064165
n3:aktivita
n10:P n10:Z
n3:aktivity
P(NT13237), Z(MSM0021620849)
n3:cisloPeriodika
11
n3:dodaniDat
n16:2013
n3:domaciTvurceVysledku
n8:8309213 n8:4511042 n8:6857108 n8:8895465 n8:8441456 n8:2810646 n8:6253393
n3:druhVysledku
n6:J
n3:duvernostUdaju
n20:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
178564
n3:idVysledku
RIV/00064165:_____/12:11831
n3:jazykVysledku
n13:eng
n3:klicovaSlova
Clinically isolated syndromes; long-term disability; follow-up; matter atrophy; relapses; abnormalities; demyelination; progression; conversion; attacks
n3:klicoveSlovo
n4:attacks n4:matter%20atrophy n4:follow-up n4:abnormalities n4:long-term%20disability n4:progression n4:demyelination n4:relapses n4:conversion n4:Clinically%20isolated%20syndromes
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[FBB2CC7B4D5F]
n3:nazevZdroje
PLoS One
n3:obor
n5:FH
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
7
n3:projekt
n17:NT13237
n3:rokUplatneniVysledku
n16:2012
n3:svazekPeriodika
7
n3:tvurceVysledku
Seidl, Zdeněk Týblová, Michaela Vaněčková, Manuela Kalinčík, Tomáš Krásenský, Jan Havrdová, Eva Horáková, Dana
n3:wos
000311272300087
n3:zamer
n19:MSM0021620849
s:issn
1932-6203
s:numberOfPages
8